Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: May 10, 2025
Language: Английский
Life Sciences, Journal Year: 2024, Volume and Issue: 356, P. 123033 - 123033
Published: Aug. 31, 2024
Language: Английский
Citations
16
Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 72, P. 101016 - 101016
Published: Nov. 3, 2023
Drug resistance remains a major challenge in cancer treatment, necessitating the development of novel strategies to overcome it. Protein arginine methyltransferases (PRMTs) are enzymes responsible for epigenetic methylation, which regulates various biological and pathological processes, as result, they attractive therapeutic targets overcoming anti-cancer drug resistance. The ongoing small molecules targeting PRMTs has resulted generation chemical probes modulating most facilitated clinical treatment advanced oncology targets, including PRMT1 PRMT5. In this review, we summarize mechanisms underlying protein methylation roles specific driving Furthermore, highlight potential implications PRMT inhibitors decreasing promote formation maintenance drug-tolerant cells via several mechanisms, altered efflux transporters, autophagy, DNA damage repair, stem cell-related function, epithelial-mesenchymal transition, disordered tumor microenvironment. Multiple preclinical trials have demonstrated that inhibitors, particularly PRMT5 can sensitize drugs, chemotherapeutic, targeted therapeutic, immunotherapeutic agents. Combining with existing will be promising approach enhanced knowledge complex functions guide future may help identify new indications.
Language: Английский
Citations
25
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 4102 - 4102
Published: April 7, 2024
Cancer stem cells (CSCs) represent a subpopulation within tumors that promote cancer progression, metastasis, and recurrence due to their self-renewal capacity resistance conventional therapies. CSC-specific markers signaling pathways highly active in CSCs have emerged as promising strategy for improving patient outcomes. This review provides comprehensive overview of the therapeutic targets associated with solid across various types, including key molecular aldehyde dehydrogenases, CD44, epithelial cellular adhesion molecule, CD133 such Wnt/β-catenin, Notch, Sonic Hedgehog. We discuss wide array modalities ranging from targeted antibodies, small molecule inhibitors, near-infrared photoimmunotherapy advanced genetic approaches like RNA interference, CRISPR/Cas9 technology, aptamers, antisense oligonucleotides, chimeric antigen receptor (CAR) T cells, CAR natural killer bispecific cell engagers, immunotoxins, drug-antibody conjugates, peptides, dendritic vaccines. spans developments preclinical investigations ongoing clinical trials, highlighting innovative targeting strategies been informed by CSC-associated molecules overcome resistance. aim provide insights into potential these therapies revolutionize treatment, underscoring critical need multi-faceted approach battle against cancer. analysis demonstrates how advances made CSC field significant novel approaches, ultimate goal achieving more effective durable responses patients.
Language: Английский
Citations
15
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12387 - 12387
Published: Nov. 18, 2024
Cancer is a multifaceted disease influenced by various mechanisms, including the generation of reactive oxygen species (ROS), which have paradoxical role in both promoting cancer progression and serving as targets for therapeutic interventions. At low concentrations, ROS serve signaling agents that enhance cell proliferation, migration, resistance to drugs. However, at elevated levels, induce oxidative stress, causing damage biomolecules leading death. cells developed mechanisms manage activating pathways such NRF2, NF-κB, PI3K/Akt. This review explores relationship between cancer, focusing on death like apoptosis, ferroptosis, autophagy, highlighting potential strategies exploit target cells.
Language: Английский
Citations
14
Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 382 - 382
Published: Jan. 24, 2025
Cancer stem cells (CSCs) play a central role in tumor progression, recurrence, and resistance to conventional therapies, making them critical focus oncology research. This review provides comprehensive analysis of CSC biology, emphasizing their self-renewal, differentiation, dynamic interactions with the microenvironment (TME). Key signaling pathways, including Wnt, Notch, Hedgehog, are discussed detail highlight potential as therapeutic targets. Current methodologies for isolating CSCs critically examined, addressing advantages limitations advancing precision medicine. Emerging technologies, such CRISPR/Cas9 single-cell sequencing, explored transformative unraveling heterogeneity informing strategies. The also underscores pivotal TME supporting survival, promoting metastasis, contributing resistance. Challenges arising from CSC-driven dormancy analyzed, along strategies mitigate these barriers, novel therapeutics targeted approaches. Ethical considerations integration artificial intelligence designing CSC-specific therapies essential elements future manuscript advocates multi-disciplinary approach that combines innovative advanced therapeutics, collaborative research address complexities CSCs. By bridging existing gaps knowledge fostering advancements personalized medicine, this aims guide development more effective cancer treatment strategies, ultimately improving patient outcomes.
Language: Английский
Citations
1
Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 87, P. 48 - 83
Published: Nov. 5, 2022
Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of transcription factor expression and/or activity enables cancer cell to acquire a stem-like state characterised capacity self-renew, differentiate and form tumours in vivo. These cells are highly metastatic therapy resistant, thus warranting more complete understanding the molecular mechanisms downstream factors that mediate establishment stemness state. Here, we review recent research findings provide mechanistic link between commonly deregulated cancer. particular, describe role master (SOX, OCT4, NANOG, KLF, BRACHYURY, SALL, HOX, FOX RUNX), signalling-regulated (SMAD, β-catenin, YAP, TAZ, AP-1, NOTCH, STAT, GLI, ETS NF-κB) unclassified (c-MYC, HIF, EMT P53) across diverse tumour types, thereby yielding comprehensive overview identifying shared targets, highlighting unique discussing complexities.
Language: Английский
Citations
31
Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1178 - 1189
Published: May 21, 2024
As the deadliest type of primary brain tumor, gliomas represent a significant worldwide health concern. Circular RNA (circRNA), unique non-coding molecule, seems to be one most alluring target molecules involved in pathophysiology many kinds cancers. CircRNAs have been identified as prospective targets and biomarkers for diagnosis treatment numerous disorders, particularly malignancies. Recent research has established clinical link between temozolomide (TMZ) resistance certain circRNA dysregulations glioma tumors. may play therapeutic role controlling or overcoming TMZ provide guidance novel kind individualized therapy. To address biological characteristics circRNAs their potential induce TMZ, this review highlighted summarized possible roles that molecular pathways drug resistance, including Ras/Raf/ERK PI3K/Akt signaling pathway metabolic processes gliomas.
Language: Английский
Citations
8
Biomedicines, Journal Year: 2022, Volume and Issue: 10(6), P. 1350 - 1350
Published: June 8, 2022
Chemotherapy is the treatment of choice for gastric cancer; however, currently available therapeutic drugs have limited efficacy. Cancer stemness and tumor microenvironment may play crucial roles in growth chemoresistance. Glucose-regulated protein 78 (GRP78) an endoplasmic reticulum chaperone facilitating folding cell homeostasis during stress participate Isoliquiritigenin (ISL) a bioactive flavonoid found licorice. In this study, we demonstrated role GRP78 cancer evaluated GRP78-mediated inhibition, regulation, chemosensitivity promotion by ISL. ISL not only suppressed stem cell-like characteristics, stemness-related expression, cancer-associated fibroblast activation but also xenograft animal studies. The findings indicated that promising candidate clinical use combination chemotherapy.
Language: Английский
Citations
25
Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)
Published: Oct. 25, 2023
Cancer Stem Cells (CSCs) are the main "seeds" for initiation, growth, metastasis, and recurrence of tumors. According to many studies, several viral infections, including human papillomaviruses, hepatitis B virus, Epstein-Barr C promote aggressiveness cancer by encouraging development CSC features. Therefore, a better method targeted elimination CSCs knowledge their regulatory mechanisms in carcinogenesis may lead future tool management treatment cancer. Oncolytic viruses (OVs), which include herpes adenovirus, vaccinia, reovirus, also new class therapeutics that have favorable properties such as selective replication tumor cells, delivery numerous eukaryotic transgene payloads, induction immunogenic cell death promotion antitumor immunity, well tolerable safety profile essentially differs from other therapeutics. The effects infection on suppression OV therapy were examined this paper. purpose review is investigate dual role (oncolytic virotherapy oncogenes).
Language: Английский
Citations
13
Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 98, P. 31 - 50
Published: Dec. 19, 2023
Language: Английский
Citations
13