Translational Oncology, Journal Year: 2024, Volume and Issue: 49, P. 102083 - 102083
Published: Aug. 10, 2024
γ-Glutamylcyclotransferase (GGCT), an enzyme crucial in glutathione metabolism, has emerged as a participant tumorigenesis. The present study is designed to elucidate the biological role and molecular mechanisms underlying GGCT glioma.
Language: Английский
Brain Communications, Journal Year: 2024, Volume and Issue: 6(3)
Published: Jan. 1, 2024
Abstract MicroRNAs act via targeted suppression of messenger RNA translation in the DNA–RNA–protein axis. The dysregulation microRNA(s) reflects epigenetic changes affecting cellular processes multiple disorders. To understand complex effect dysregulated microRNAs linked to neurodegeneration, we performed a cross-sectional microRNA expression analysis idiopathic Parkinson's disease (n = 367), progressive supranuclear palsy 35) and healthy controls 416) from Luxembourg Study, followed by prediction modelling, enriched pathway target simulation using probabilistic Boolean modelling. Forty-six were identified be versus 16 with 4 overlapping significantly between comparisons. Predictive power subsets (including up 100 microRNAs) was modest for differentiating or (maximal cross-validated area under receiver operating characteristic curve 0.76 0.86, respectively) low 0.63). revealed natural killer cell both, controls, indicating that immune system might play an important role both diseases. Probabilistic modelling dynamics affected partially activity transcription factor EB, endoplasmic reticulum stress signalling, calcium signalling pathway, dopaminergic peroxisome proliferator-activated receptor gamma coactivator-1α activity, though involving different mechanisms. These findings indicated convergent (sub)cellular end-point dysfunction at levels palsy, but distinctive underlying molecular
Language: Английский
Citations
4
Biology, Journal Year: 2025, Volume and Issue: 14(3), P. 272 - 272
Published: March 7, 2025
Neural excitatory/inhibitory (E/I) imbalance plays a pivotal role in the aging process. However, despite its significant impact, of E/I motor dysfunction and neurodegenerative diseases has not received sufficient attention. This review explores mechanisms underlying through lens balance, emphasizing genetic molecular factors that contribute to this (such as SCN2A, CACNA1C, GABRB3, GRIN2A, SYT, BDNF…). Key regulatory genes, including REST, vps-34, STXBP1, are examined for their roles modulating synaptic activity neuronal function during aging. With insights drawn from ALS, we discuss how disruptions balance pathophysiology age-related dysfunction. The genes discussed above exhibit certain association with neuron (like ALS), relationship had been previously recognized. Innovative therapies, such gene editing technology optogenetic manipulation, emerging promising tools restoring offering hope ameliorating deficits potential these technologies intervene aging-related diseases, challenges direct application human conditions.
Language: Английский
Citations
0
Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 733, P. 150597 - 150597
Published: Aug. 23, 2024
A significant quantity of substance P (SP) and its receptor, the neurokinin 1 (NK1) receptors are found in brain. SP is a neuropeptide distributed central nervous system functions as neurotransmitter, neuromodulator, neurotrophic factor. The concentrations brain cerebrospinal fluid fluctuate individuals with Alzheimer's disease (AD). an endogenous ligand for NK1 enhancing expression toll-like (TLR) vice versa. So, both pathways interconnected, where activation one pathway activates second pathway. Researchers have observed interaction TLR pathophysiology AD. Thus, this review discusses various TLRs involved regulating amyloid processing Further, AD pathology, can regulate non-amyloidogenic Recent studies also demonstrated capacity voltage-gated potassium channel currents, emphasizing SP's neuroprotective ability. Therefore, we corroborate findings linking SP, NK1R,
Language: Английский
Citations
3
Translational Oncology, Journal Year: 2024, Volume and Issue: 49, P. 102083 - 102083
Published: Aug. 10, 2024
γ-Glutamylcyclotransferase (GGCT), an enzyme crucial in glutathione metabolism, has emerged as a participant tumorigenesis. The present study is designed to elucidate the biological role and molecular mechanisms underlying GGCT glioma.
Language: Английский
Citations
2