Innovative Green Stability-Indicating HPLC Method Coupled with Fluorescence Detection for Determination of Antidiabetic Agent Canagliflozin

Talanta Open, Journal Year: 2025, Volume and Issue: unknown, P. 100436 - 100436

Published: March 1, 2025

Language: Английский

---

Green vibrational spectroscopic approach for simultaneous quantification of antihypertensive drugs in bulk and tablet formulations

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 16, 2025

The selection of IR spectroscopic approach for quantification drugs supports green analytical chemistry principles without compromising the method performance. follows pressed pellet technique preparing samples using potassium bromide any toxic solvents and even reduced waste too. An easy, fast, environmentally friendly FT-IR spectrophotometric was developed validated simultaneous measurement amlodipine besylate (AML) telmisartan (TEL) in pharmaceutical combination formulations. absorbance spectra which obtained from transmittance were used determining area under curve correlated with amount or concentration. AML TEL shows peaks at 1206 cm- 1 863 1. Validation followed ICH guidelines all validation results within limits. LOD LOQ found as 0.009359 %w/w, 0.028359 %w/w respectively where it to be 0.008241 0.024974 respectively. MoGAPI, AGREE prep, RGB model assessment procedure sustainable. described HPLC not significantly different statistically.

Language: Английский

---

Paper based analytical platforms: A matrix adaptable approach to drug testing

Talanta Open, Journal Year: 2024, Volume and Issue: 10, P. 100338 - 100338

Published: June 18, 2024

Paper-based analytical devices (PADs) are becoming increasingly popular for drug analysis in various matrices. These affordable, portable platforms come with a range of benefits, such as their user-friendly design, straightforward operation, and minimal need sample preparation. This study evaluates the potential applications PADs testing particular emphasis on adaptability terms ability to handle types samples during process. In this study, manufacturing, performance detection, well influence that different biological have PAD were investigated. discussed paper, respect forensic analysis, point-of-care illicit testing. The demonstrates flexibility varied authors highlight fact inexpensive, portable, user-friendly, minimum preparation, which makes them effective instruments variety situations, including research, law enforcement, healthcare. On whole, paper highlights versatility PADs, emphasizing role adaptable within Scientists professionals can utilize these cutting-edge improve efficiency accessibility analysis.

Language: Английский

---

Estimation of isoniazid by digital image colorimetry: an integration of green chemistry and smartphone technology

Future Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 10(1)

Published: Sept. 19, 2024

Abstract Background This study proposes a simple digital image colorimetric method using smartphone for the quantitative analysis of isoniazid in pharmaceutical medications. The analytical methodology employed this involved utilization reaction between and FC reagent under alkaline conditions. chemical led to creation complex with blue-gray color, exhibiting peak absorption at wavelength 760 nm. An Android application was perform smartphone-based determination based on separating captured color into different channels such as red, blue, green, etc. experimental procedure three smartphones determination, which subsequently followed by comparative results obtained from these devices spectrophotometric measurements. Results B channel had highest level optimization terms parameters. limits detection (LOD) were 0.586, 2.478, 1.396 µg/ml S1, S2, S3, respectively, spectrophotometer, it found be 0.416 µg/ml. Similarly, LOQs determined 1.673, 7.511, 4.232, 1.302 A %RSD 1.3 precision an LOD 0.013 g dm −3 spectroscopic method. % recovery accuracy 99.69, 101.804, 109.28, 100.13 respectively. Conclusion are similar those analyses.

Language: Английский

---

Green and Sensitive Analysis of the Antihistaminic Drug Pheniramine Maleate and Its Main Toxic Impurity Using UPLC and TLC Methods, Blueness Assessment, and Greenness Assessments

Chemosensors, Journal Year: 2024, Volume and Issue: 12(10), P. 206 - 206

Published: Oct. 9, 2024

For the first time, two direct and eco-friendly chromatographic approaches were adapted for simultaneous estimation of pheniramine maleate (PAM) its major toxic impurity, 2-benzyl pyridine (BNZ). Method A used reversed-phase ultra-performance liquid chromatography; separation was achieved within 4 min using a C18 column with developing system methanol/water (60:40 v/v) 0.1 mL/min flow rate. Photodiode array detection adjusted at 215 nm. The method linear in ranges 5.0–70.0 0.05–10.0 µg/mL PAM BNZ, correspondingly. B thin-layer applied on silica gel TLC F254 ethanol/ethyl acetate/liquid ammonia (8:2:0.1, volumes) room temperature, 265 Linearity assured concentration 0.5–8.0 0.1–3.0 µg/band components, respectively. Generally, new UPLC methods outperform old ones terms quickness, greenness, sensitivity. Concisely, greenness features partially Green Analytical Procedure Index (GAPI) Greenness (AGREE) pictograms. In contrast, usefulness novel via Blue Applicability Grade (BAGI) tool.

Language: Английский

---

Validated green and white RP-HPLC method for the estimation of Zolmitriptan in marketed dosage form

Annales Pharmaceutiques Françaises, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Language: Английский

---

Assessing environmental sustainability of HPLC methods for tri-combination anti-hypertensive drug analysis

Green Analytical Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 100182 - 100182

Published: Nov. 1, 2024

Language: Английский

---