Click Chemistry: A Tool for Green Chemistry DOI
Luigi Vaccaro,

Brufani Giulia

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

New Opportunities for Organic Synthesis with Superheated Flow Chemistry DOI Creative Commons
Pauline Bianchi, Jean‐Christophe M. Monbaliu

Accounts of Chemical Research, Journal Year: 2024, Volume and Issue: 57(15), P. 2207 - 2218

Published: July 23, 2024

ConspectusFlow chemistry has brought a fresh breeze with great promises for chemical manufacturing, yet critical deterrents persist. To remain economically viable at production scales, flow processes demand quick reactions, which are actually not that common. Superheated technology stands out as promising alternative poised to confront modern challenges. While continuous micro- and mesofluidic reactors offer uniform heating rapid cooling across different operating above solvent boiling points (i.e., under superheated conditions) significantly enhances reaction rates. Despite the energy costs associated high temperatures, aligns sustainability goals by improving productivity (process intensification), offering flexibility, enhancing safety.However, navigating unconventional space of can be cumbersome, particularly neophytes. Expanding temperature/pressure process window beyond conventional point atmospheric pressure limit vastly increases optimization space. When trial-and-error approaches, this become exceedingly wasteful, resource-intensive, discouraging. Over years, chemists have developed various tools mitigate these challenges, an increased reliance on statistical models, artificial intelligence, experimental (kinetics, preliminary test reactions microwave irradiation) or theoretical (quantum mechanics)

Language: Английский

Citations

4
Accelerating rational organoborazine discovery: predicted by machine learning, synthesized under continuous flow DOI Creative Commons

Alireza Nazari Khodadadi,

Ejdi Cela, Hamidreza Mosaffa

et al.

Green Synthesis and Catalysis, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Continuous flow synthesis of 1,4-disubstituted 1,2,3-triazoles via consecutive β-azidation of α,β-unsaturated carbonyl compounds and CuAAC reactions DOI Creative Commons

Giulia Brufani,

Federica Valentini,

Gabriele Rossini

et al.

Green Chemistry, Journal Year: 2023, Volume and Issue: 25(6), P. 2438 - 2445

Published: Jan. 1, 2023

We herein report a multi-step flow protocol for the synthesis of 1,4-disubstituted 1,2,3-triazoles starting from α,β-unsaturated carbonyls.

Language: Английский

Citations

8
Copper(I)-catalyzed interrupted click/radical relay: A four-component modular synthesis of triazole sulfones DOI
Pengfei Sun, Fang Wei, Chen‐Ho Tung

et al.

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 35(3), P. 108478 - 108478

Published: April 22, 2023

Language: Английский

Citations

7
Efficient access to hexaaryl-substituted borazines in batch and continuous-flow DOI Creative Commons

Alireza Nazari Khodadadi,

Ejdi Cela,

Dario Marchionni

et al.

Green Chemistry, Journal Year: 2024, Volume and Issue: 26(12), P. 7059 - 7066

Published: Jan. 1, 2024

Green inspired synthesis of hexaaryl-substituted borazines.

Language: Английский

Citations

2
Co-immobilization of amine dehydrogenase and glucose dehydrogenase for the biosynthesis of (S)-2-aminobutan-1-ol in continuous flow DOI Creative Commons
Pengcheng Xie, Lan Jin,

Jingshuan Zhou

et al.

Bioresources and Bioprocessing, Journal Year: 2024, Volume and Issue: 11(1)

Published: July 18, 2024

Abstract Reductive amination by amine dehydrogenases is a green and sustainable process that produces only water as the by-product. In this study, continuous flow was designed utilizing packed bed reactor filled with co-immobilized dehydrogenase wh84 glucose for highly efficient biocatalytic synthesis of chiral amino alcohols. The immobilized exhibited better thermo-, pH solvent stability high activity recovery. ( S )-2-aminobutan-1-ol produced in up to 99% conversion ee processes, space-time yields were 124.5 g L -1 d . reactions also extended 48 h affording 91.8% average conversions. This study showcased important potential production alcohols processes.

Language: Английский

Citations

1
Advances in diarylpyrimidines and related analogues as HIV-1 nonnucleoside reverse transcriptase inhibitors (2019-2023) DOI
M. Nie, Shuang‐Shuang Zhang, Shuang‐Xi Gu

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 280, P. 116973 - 116973

Published: Oct. 18, 2024

Language: Английский

Citations

1
Click Chemistry: A Tool for Green Chemistry DOI
Luigi Vaccaro,

Brufani Giulia

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0