Proximate causes and ultimate effects of common antidepressants, fluoxetine and venlafaxine, on fish behavior

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 807, P. 150846 - 150846

Published: Oct. 7, 2021

Language: Английский

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Sub-chronic exposure to paroxetine disrupts ecologically relevant behaviours in fish

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 917, P. 170405 - 170405

Published: Jan. 26, 2024

The functional conservation of important selective serotonin reuptake inhibitor (SSRI) targets in non-target organisms raises concerns about their potential adverse effects on the ecosystems. Although environmental levels SSRIs like paroxetine (PAR) have risen, knowledge regarding long-term exposure to PAR is limited. This study investigated impact sub-chronic (21 days) two sub-lethal concentrations (40 and 400 μg/L) behaviour adult zebrafish different scenarios: basal activity (under dark light conditions), stress response (evoked by sudden transitions) recovery. A new framework was employed for integrative fish's swimming performance based innate ability respond shifts. Several swimming-associated parameters (e.g., total distance, time inactivity, angles) thigmotaxis were monitored an integrated analysis each scenario. Data revealed reduced activity, impaired behavioural alterations recovery PAR-exposed fish. An anxiolytic effect particularly noticeable fish at μg/L (from light) dark) exposed 40 μg/L. detected PAR-induced modifications suggest a disruption brain glucocorticoid signalling that may implications individual level changing responses predators), with repercussions population community levels. Therefore, applied protocol proved sensitive detecting changes induced PAR.

Language: Английский

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Fluoxetine-induced neurotoxicity at environmentally relevant concentrations in adult zebrafish Danio rerio

NeuroToxicology, Journal Year: 2022, Volume and Issue: 90, P. 121 - 129

Published: March 15, 2022

Language: Английский

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Ecotoxicological effects of the antidepressant fluoxetine and its removal by the typical freshwater microalgae Chlorella pyrenoidosa

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 244, P. 114045 - 114045

Published: Aug. 30, 2022

The antidepressant fluoxetine (FLX) has gained increasing attention due to its frequent detection in aquatic environments and negative effects on non-target organisms. However, knowledge the ecotoxicological of FLX removal by microalgae is still limited. In this study, (10 -1000 μg/L) were assessed using batch cultures freshwater Chlorella pyrenoidosa for 10 days based changes growth, antioxidant response, photosynthetic process. efficiency, mechanism, degradation pathway C. also investigated. results showed that growth was inhibited with a 4 d EC50 0.464 mg/L. Additionally, significantly photosynthesis caused oxidative stress day 4. can produce resistance acclimatize FLX, as reflected declining inhibition rate, recovered disappearance 10. Despite toxicity 41.2%- 100% after exposure. Biodegradation primary accounting 88.2%- 92.8% total FLX. A five metabolites found processes which less than main pathways proposed demethylation, O-dealkylation, hydroxylation, N-acylation. Our not only highlight potential application purification, but provide insight into fate ecological risk environments.

Language: Английский

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Disruptive ecotoxicological effects of fluoxetine on serotoninergic signaling and enteric neurogenesis in early zebrafish larvae (Danio rerio)

Environmental Toxicology and Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 104698 - 104698

Published: April 1, 2025

Language: Английский

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Urban stressors: Interactive effects of noise, light regime and fluoxetine on zebrafish behavior

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 972, P. 179101 - 179101

Published: March 17, 2025

Language: Английский

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Anthropogenic Impacts as a Driver of Sensory Organ Morphology

Wild, Journal Year: 2025, Volume and Issue: 2(2), P. 17 - 17

Published: May 7, 2025

All animals require the ability to use visual, auditory, tactile, and olfactory information survive through activities including locating identifying conspecifics potential mates, food or shelter, noticing an approaching predator. Detecting such invariably requires sensory organs. The morphology of organs evolves under natural selection optimise detect salient cues signals against background noise in environment. rapidly proliferating anthropogenic impacts on almost all environments include light, noise, chemical pollution, which can interfere with animal’s acoustic seismic, information, respectively. Many studies examine resulting changes characteristics behavioural responses them affected populations, but very few required signals; those that do find evidence morphological changes. Here, I review current knowledge impact pollution organ wild captive highlighting gaps future directions for addressing them. This is especially important context growing recognition cruciality ecology design effective threatened species conservation programs invasive management strategies.

Language: Английский

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Sex-specific effect of long-term fluoxetine exposure on inhibitory control in guppies (Poecilia reticulata)

Behavioral Ecology and Sociobiology, Journal Year: 2025, Volume and Issue: 79(5)

Published: May 1, 2025

Language: Английский

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Widespread psychoactive pollutant augments daytime restfulness and disrupts diurnal activity rhythms in fish

Chemosphere, Journal Year: 2023, Volume and Issue: 326, P. 138446 - 138446

Published: March 20, 2023

Pharmaceutical pollution is a major driver of global change, with the capacity to alter key behavioural and physiological traits in exposed animals. Antidepressants are among most commonly detected pharmaceuticals environment. Despite well-documented pharmacological effects antidepressants on sleep humans other vertebrates, very little known about their ecologically relevant impacts as pollutants non-target wildlife. Accordingly, we investigated acute 3-day exposure eastern mosquitofish (Gambusia holbrooki) field-realistic levels (nominal concentrations: 30 300 ng/L) widespread psychoactive pollutant, fluoxetine, diurnal activity patterns restfulness, indicators disruptions sleep. We show that fluoxetine disrupted diel patterns, which was driven by augmentation daytime inactivity. Specifically, unexposed control fish were markedly diurnal, swimming farther during day exhibiting longer periods more bouts inactivity at night. However, fluoxetine-exposed fish, this natural rhythm eroded, no differences or restfulness observed between As misalignment circadian has been shown adversely affect fecundity lifespan animals, our findings reveal potentially serious threat survival reproductive success pollutant-exposed

Language: Английский

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Effects of parental exposure to amitriptyline on the survival, development, behavior, and gene expression in zebrafish offspring

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 169173 - 169173

Published: Dec. 6, 2023

Language: Английский

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