ASAIO Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 14, 2024
There
is
insufficient
data
on
the
outcomes
of
donation
after
circulatory
death
(DCD)
multiorgan
transplant
that
includes
heart.
The
primary
objective
this
study
to
compare
overall
survival
DCD
and
brain
(DBD)
transplants.
We
identified
all
heart
patients
from
2019
June
2023
using
United
Network
for
Organ
Sharing
(UNOS)
Database
who
also
received
an
additional
organ
(kidney,
liver,
lungs).
A
total
1,844
DBD
91
transplants
occurred
within
period,
majority
being
combined
heart-kidney
transplantation.
More
were
listed
at
a
higher
status
in
group
(
p
<
0.05)
intensive
care
unit
(ICU)
before
0.05).
Despite
ischemia
time
0.05),
unmatched
did
not
differ
between
two
groups
Within
transplants,
either
or
matched
(unmatched
=
0.5,
0.5).
In
conclusion,
are
limited.
Still,
our
analysis
currently
available
suggests
comparable
Circulation Heart Failure,
Journal Year:
2024,
Volume and Issue:
17(7)
Published: June 20, 2024
Orthotopic
heart
transplant
is
the
gold
standard
therapeutic
intervention
for
patients
with
end-stage
failure.
Conventionally,
has
relied
on
donation
after
brain
death
organ
recovery.
Donation
circulatory
(DCD)
of
confirming
that
function
irreversibly
ceased.
DCD-orthotopic
differs
from
death-orthotopic
in
ways
carry
implications
widespread
adoption,
including
differences
recovery,
storage
and
ethical
considerations
surrounding
normothermic
regional
perfusion
DCD.
Despite
these
differences,
DCD
shown
promising
early
outcomes,
augmenting
donor
pool
allowing
more
individuals
to
benefit
orthotopic
transplant.
This
review
aims
present
current
state
future
trajectory
DCD-heart
transplant,
examine
key
between
death,
clinical
experiences
innovations
methodologies,
address
ongoing
challenges
new
frontier
donors.
Current Cardiology Reports,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 9, 2024
Abstract
Purpose
of
Review
To
summarise
current
international
clinical
outcomes
from
donation
after
circulatory
death
heart
transplantation
(DCD-HT);
discuss
procurement
strategies,
their
impact
on
and
overall
organ
procurement;
identify
novel
approaches
future
areas
for
research
in
DCD-HT.
Recent
Findings
Globally,
DCD-HT
survival
(regardless
strategy)
are
comparable
to
brain
dead
donors
(BDD).
Experience
with
normothermic
machine
perfusion
sees
improvement
rates
primary
graft
dysfunction.
Techniques
have
evolved
reduce
cold
ischaemic
exposure
directly
procured
DCD
hearts,
though
controlled
periods
ischaemia
can
likely
be
tolerated.
There
is
interest
hypothermic
(HMP)
promising
early
results.
Summary
Survival
firmly
established
equivalent
between
BDD
Procurement
strategy
(direct
vs.
regional
perfusion)
remains
a
source
debate.
Methods
improve
allograft
warm
tolerance
will
key
the
uptake
HMP
hearts.
Transplant International,
Journal Year:
2025,
Volume and Issue:
38
Published: Feb. 14, 2025
Heart
transplant
for
adults
following
Donation
after
Circulatory
Death
(DCD)
is
well
established
in
many
parts
of
the
world,
including
United
Kingdom
(UK).
Small
child
DCD
hearts
have
now
been
recovered
UK
and
internationally
utilising
novel
technologies.
Despite
these
recent
advances,
extension
this
practice
to
pediatric
cardiac
transplantation
has
slow
difficult
despite
severe
shortage
donors
children
leading
a
high
number
deaths
annually
waiting
heart
transplant.
This
direct
contrast
with
thriving
programme
adult
donation
non-cardiac
organs.
There
insufficient
action
addressing
inequality
thus
far.
Barriers
development
are
multifaceted:
ethical
concerns,
technological
paucity,
financial
logistical
hurdles.
We
describe
background,
live
issues,
current
developments
how
we
driving
resources
toward
sustainable
small
provide
valuable
insights
other
countries
elements
principles
at
play.
call
responsible
bodies
take
urgent
achievable
actions
establish
an
equitable
paediatric
donors,
recipients
their
families.
Clinical Transplantation,
Journal Year:
2025,
Volume and Issue:
39(3)
Published: March 1, 2025
ABSTRACT
Introduction
Use
of
normothermic
regional
perfusion
(NRP)
to
recover
donation
after
circulatory
death
(DCD)
organs
demonstrates
increased
heart
utilization
with
favorable
outcomes.
Conversely,
DCD
lung
allograft
use
when
NRP
was
employed
remains
controversial.
This
is
a
contemporary
analysis
recipient
outcomes
in
which
used.
Methods
Utilizing
the
STAR‐OPTN
database,
all
adult
recipients
United
States
between
January
1,
2020,
and
June
30,
2024
were
identified.
defined
if
time
donor
aortic
clamp
greater
than
30
min.
Recipient
outcomes,
including
30‐,
60‐,
90‐day
mortality,
grade‐3
primary
graft
dysfunction
(PGD),
postoperative
length
stay
compared
using
multivariable
logistic
regression
controlling
for
covariates.
Survival
performed
Cox
proportional
hazard
modeling.
Results
Of
987
transplants,
92
(9.4%)
utilized
NRP.
There
no
differences
characteristics
direct
recovery
cohorts.
No
difference
or
PGD,
found
12‐month
survival
equivalent.
Conclusions
Outcomes
equivalent
recipients.
Thus,
lungs
may
be
considered
transplantation
following
procedures.
Transplantology,
Journal Year:
2025,
Volume and Issue:
6(2), P. 11 - 11
Published: April 17, 2025
The
growing
disparity
between
the
demand
for
donor
hearts
and
their
availability
has
reignited
interest
in
donation
after
circulatory
death
(DCD)
heart
transplantation.
Historically,
DCD
transplantation
been
overshadowed
by
brain
(DBD)
due
to
ethical
preservation
challenges.
However,
recent
advancements
procurement
techniques
allow
evaluation
of
enable
broader
utilization
donors.
While
challenges
remain,
early
outcomes
suggest
comparable
survival
rates
DBD
This
review
provides
a
comprehensive
overview
historical
evolution,
current
practices,
future
directions
Here,
we
emphasize
its
potential
expand
pool
alleviate
organ
shortage
crisis.
Journal of Thoracic and Cardiovascular Surgery,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
To
clarify
the
association
between
warm
ischemic
time
during
donation
after
circulatory
death
(DCD)
and
severe
primary
graft
dysfunction
(PGD)
heart
transplant.
DCD
transplants
using
normothermic
regional
perfusion,
excluding
congenital
etiology
or
multiorgan
transplant,
at
a
single
institution
from
January
2020
to
December
2024
were
reviewed.
Donation
withdrawal
(DWIT),
functional
time,
defined
by
oxygen
saturation
<80%
(FWIT
O2),
systolic
blood
pressure
<80
mm
Hg
<50
Hg,
asystolic
examined.
Propensity
matching
created
balanced
cohorts
associate
ischemia
outcomes.
Outcomes
included
incidence
of
PGD,
lengths
stay,
mortality.
The
final
study
cohort
had
135
patients,
whom
10
(7.4%)
PGD.
When
stratified
donor
recipient
demographics
similar.
DWIT
(median
25.0
minutes
vs
35.5
minutes,
P
=
.031)
FWIT
O2
22.0
33.0
.025)
lower
in
those
without
Logistic
regression
identified
as
better
predictor
compared
with
DWIT.
Receiver
operating
characteristic
curve
analysis
threshold
23
(area
under
curve,
0.714).
After
matching,
rates
PGD
significantly
greater
>23
group
(8/59
[13.6%]
1/59
[1.7%],
.032).
However,
similar
stay
In
perfusion
is
associated
increased
was
not
other
outcomes,
including
Rejection
allografts
on
basis
prolonged
may
lead
unnecessary
discard
viable
hearts.
