Drug development & registration,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 12, 2023
Introduction.
Improving
the
technologies
for
isolating
and
purifying
biologically
active
substances
from
plant
materials
is
an
important
task
pharmaceutical,
food
cosmetic
industries.
Technology
development
often
requires
changes
to
design
of
existing
equipment.
During
modernization
equipment
implementation
new
technologies,
it
possible
improve
its
configuration,
which
makes
significantly
increase
yield
at
minimal
cost.
To
efficiency
process
hesperidin
materials,
we
proposed
use
a
number
technological
solutions.
In
particular,
mixing
devices
with
configuration
impellers
obtained
by
computational
fluid
dynamics,
when
using
Soxhlet
extractor
heated
extraction
chamber,
adding
external
coil
jacket,
regulate
temperature
inside
chamber
accelerate
processes
diffusion
mass
transfer,
select
solvent
extractant
on
basis
thermodynamic
models
calculation.
Aim.
technology
modernized
Materials
methods.
Flow
distribution
in
apparatuses
was
modeled
dynamics
evaluate
results
modeling,
experiments
were
carried
out,
object
peel
orange
(dried
flavedo
albedo,
grinding
degree
0.1–0.2
mm,
moisture
content
3.5
%).
The
quantitative
flavonoid
complex
terms
determined
direct
spectrophotometry
wavelength
290
nm,
gravimetrically.
Statistical
data
processing
performed
Minitab
v21
software
(Minitab
Inc.,
USA),
differences
considered
statistically
significant
p
<
0.05.
Results
discussion.
Based
methods
intensify
dissolution
stages
preliminary
degreasing
raw
extraction,
six-bladed
impeller
designed,
these
creating
axial
radial
flows
movement
capacitive
apparatus
maintaining
suspended
state
volume
liquid
low
speeds
energy
consumption.
Equipping
coiled
jacket
made
solubility
substance
extract
more
target
component
one
cycle.
A
isolation
purification
developed,
parameters
optimized.
Conclusion.
As
result
study,
shown
that
selecting
method
dynamics.
isolate
poorly
soluble
compounds
dense
(roots,
bark,
etc.),
modification
proposed.
Modernization
typical
units
obtain
up
95
%
purity
90
single
recrystallization.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(4), P. 1845 - 1845
Published: Feb. 15, 2023
Phenolic
compounds
and
flavonoids
are
potential
substitutes
for
bioactive
agents
in
pharmaceutical
medicinal
sections
to
promote
human
health
prevent
cure
different
diseases.
The
most
common
found
nature
anthocyanins,
flavones,
flavanones,
flavonols,
flavanonols,
isoflavones,
other
sub-classes.
impacts
of
plant
phenolics
on
promoting
diseases
curing
preventing
antioxidant
effects,
antibacterial
impacts,
cardioprotective
anticancer
immune
system
promoting,
anti-inflammatory
skin
protective
effects
from
UV
radiation.
This
work
aims
provide
an
overview
phenolic
as
important
sources
medical
application
according
recently
published
studies,
well
some
interesting
directions
future
research.
keyword
searches
flavonoids,
phenolics,
tannins,
coumarins,
lignans,
quinones,
xanthones,
curcuminoids,
stilbenes,
cucurmin,
phenylethanoids,
secoiridoids
were
performed
by
using
Web
Science,
Scopus,
Google
scholar,
PubMed.
acids
contain
a
carboxylic
acid
group
addition
the
basic
structure
mainly
divided
into
hydroxybenzoic
hydroxycinnamic
acids.
Hydroxybenzoic
based
C6-C1
skeleton
often
bound
small
organic
acids,
glycosyl
moieties,
or
cell
structural
components.
Common
include
gallic,
syringic,
protocatechuic,
p-hydroxybenzoic,
vanillic,
gentistic,
salicylic
Hydroxycinnamic
C6-C3
also
molecules
such
quinic
glucose.
main
caffeic,
p-coumaric,
ferulic,
sinapic
Life,
Journal Year:
2023,
Volume and Issue:
13(3), P. 617 - 617
Published: Feb. 23, 2023
The
outbreak
of
coronavirus
disease
2019
(COVID-19)
caused
by
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
had
a
profound
impact
on
the
world’s
health
and
economy.
Although
end
pandemic
may
come
in
2023,
it
is
generally
believed
that
virus
will
not
be
completely
eradicated.
Most
likely,
become
an
endemicity.
rapid
development
vaccines
different
types
(mRNA,
subunit
protein,
inactivated
virus,
etc.)
some
other
antiviral
drugs
(Remdesivir,
Olumiant,
Paxlovid,
has
provided
effectiveness
reducing
COVID-19’s
worldwide.
However,
circulating
SARS-CoV-2
been
constantly
mutating
with
emergence
multiple
variants,
which
makes
control
COVID-19
difficult.
There
still
pressing
need
for
developing
more
effective
to
fight
against
disease.
Plants
have
promising
production
platform
both
bioactive
chemical
compounds
(small
molecules)
recombinant
therapeutics
(big
molecules).
naturally
produce
diverse
range
as
secondary
metabolites,
such
alkaloids,
terpenoids/terpenes
polyphenols,
are
rich
source
countless
compounds.
can
also
genetically
engineered
valuable
therapeutics.
This
molecular
farming
plants
unprecedented
opportunity
vaccines,
antibodies,
biologics
diseases
because
its
potential
advantages,
low
cost,
safety,
high
volume.
review
summarizes
latest
advancements
plant-derived
used
combat
discusses
prospects
challenges
plant-based
agents.
Viruses,
Journal Year:
2024,
Volume and Issue:
16(2), P. 218 - 218
Published: Jan. 31, 2024
Most
plants
have
developed
unique
mechanisms
to
cope
with
harsh
environmental
conditions
compensate
for
their
lack
of
mobility.
A
key
part
coping
is
the
synthesis
secondary
metabolites.
In
addition
role
in
plants'
defense
against
pathogens,
they
also
possess
therapeutic
properties
diseases,
and
use
by
humans
predates
written
history.
Viruses
are
a
class
submicroscopic
agents,
incapable
independent
existence
outside
living
host.
Pathogenic
viruses
continue
pose
significant
threat
global
health,
leading
innumerable
fatalities
on
yearly
basis.
The
medicinal
as
natural
source
antiviral
agents
has
been
widely
reported
literature
past
decades.
Metabolomics
powerful
research
tool
identification
plant
metabolites
potentials.
It
can
be
used
isolate
compounds
capacities
study
biosynthetic
pathways
involved
viral
disease
progression.
This
review
discusses
special
focus
metabolomics
evidence
supporting
efficacy.
Suggestions
made
optimization
various
methods
characterizing
bioactive
subsequently
understanding
operation.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(12), P. 4860 - 4860
Published: June 20, 2023
The
ongoing
COVID-19
pandemic
has
resulted
in
a
global
panic
because
of
its
continual
evolution
and
recurring
spikes.
This
serious
malignancy
is
caused
by
the
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2).
Since
outbreak,
millions
people
have
been
affected
from
December
2019
till
now,
which
led
to
great
surge
finding
treatments.
Despite
trying
handle
with
repurposing
some
drugs,
such
as
chloroquine,
hydroxychloroquine,
remdesivir,
lopinavir,
ivermectin,
etc.,
against
COVID-19,
SARS-CoV-2
virus
continues
out-of-control
spread.
There
dire
need
identify
new
regimen
natural
products
combat
deadly
viral
disease.
article
deals
literature
reports
date
showing
inhibitory
activity
towards
through
different
approaches,
vivo,
vitro,
silico
studies.
Natural
compounds
targeting
proteins
SARS-CoV-2-the
main
protease
(M
