Aniline Derivatives Containing 1-Substituted 1,2,3-Triazole System as Potential Drug Candidates: Pharmacokinetic Profile Prediction, Lipophilicity Analysis Using Experimental and In Silico Studies DOI Creative Commons
Elwira Chrobak, Katarzyna Bober, Mirosław Wyszomirski

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1476 - 1476

Published: Nov. 2, 2024

Background: The triazole ring is an attractive structural unit in medicinal chemistry, and chemical compounds containing this type of system their structure exhibit a wide spectrum biological activity. They are used the development new pharmaceuticals. One basic parameters considered initial phase designing potential drugs lipophilicity, which affects bioavailability pharmacokinetics drugs. Methods: study aimed to assess lipophilicity fifteen derivatives aniline using reversed thin layer chromatography (RP-TLC) free web servers. Based on silico methods, drug similarity pharmacokinetic profile (ADMET) synthesized molecules were assessed. Results: A relationship was observed between title compound, including position substitution ring, experimental values (logPTLC). Most algorithms determine theoretical logP showed less sensitivity differences tested molecules. All obtained satisfy rules formulated by Lipinski, Ghose Veber. Moreover, analysis ADME favorable related absorption.

Language: Английский

Antibacterial Activity of Selected Essential Oil Components and Their Derivatives: A Review DOI Creative Commons
Vuyolwethu Khwaza, Blessing A. Aderibigbe

Antibiotics, Journal Year: 2025, Volume and Issue: 14(1), P. 68 - 68

Published: Jan. 10, 2025

Essential oils (EOs) are gaining ground and have been intensively studied due to their widespread use in the pharmaceutical, food, cosmetics industries. The essential components of EOs recognized for diverse therapeutic activities gained significant attention potential antibacterial activities. Despite popularity potent biological properties, bioactive derivatives still not comprehensively characterized. This review explores efficacy selected EO derivatives, focusing on monoterpenes chosen (i.e., carvacrol, menthol, thymol) phenylpropanoids cinnamaldehyde eugenol). Furthermore, this highlights recent advancements developing these components, which shown improved activity with reduced toxicity. By summarizing studies, reveals natural compounds as promising candidates pharmaceuticals, food preservation, alternatives synthetic antibiotics combating bacterial resistance.

Language: Английский

Citations

4
Carvacrol and Thymol Hybrids: Potential Anticancer and Antibacterial Therapeutics DOI Creative Commons
Sijongesonke Peter, Namhla Sotondoshe, Blessing A. Aderibigbe

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(10), P. 2277 - 2277

Published: May 12, 2024

Cancer is ranked among lethal diseases globally, and the increasing number of cancer cases deaths results from limited access to effective therapeutics. The use plant-based medicine has been gaining interest several researchers. Carvacrol its isomeric compound, thymol, are extracts that possess biological activities, such as antimalarial, anticancer, antifungal, antibacterial. However, their efficacy compromised by poor bioavailability. Thus, medicinal scientists have explored synthesis hybrid compounds containing pharmacophores enhance therapeutic improve Hence, this review a comprehensive report on carvacrol isomer, with potent anticancer antibacterial agents reported between 2020 2024. Furthermore, structural activity relationship (SAR) recommended future strategies further effects will be discussed.

Language: Английский

Citations

11
An updated review on 1,2,3-/1,2,4-triazoles: synthesis and diverse range of biological potential DOI

Anirudh Pratap Singh Raman,

M. Aslam, Amardeep Awasthi

et al.

Molecular Diversity, Journal Year: 2024, Volume and Issue: unknown

Published: July 27, 2024

Language: Английский

Citations

7
Evaluation of the synergistic antifungal effects of thymol and cinnamaldehyde combination and its mechanism of action against Rhizopus stolonifer in vitro and in vivo DOI

Hsu Mon Phyo,

Jian Ju, Qais Ali Al‐Maqtari

et al.

Biocatalysis and Agricultural Biotechnology, Journal Year: 2023, Volume and Issue: 49, P. 102658 - 102658

Published: Feb. 20, 2023

Language: Английский

Citations

14
Pharmacological Significance of 1,2,3-Triazoles DOI
Mubarak H. Shaikh, Amol A. Nagargoje, Dattatraya N. Pansare

et al.

Advances in chemical and materials engineering book series, Journal Year: 2025, Volume and Issue: unknown, P. 155 - 202

Published: Jan. 3, 2025

Click chemistry is not a single specific reaction, but was meant to mimic nature, which also generates substances by joining small modular units. The 1,3-dipolar azide, alkyne cycloaddition (CuAAC) reaction catalyzed copper, as nearly quantitative and easy execute has emerged the leading example of “click chemistry”. Given importance triazole scaffold in medicinal chemistry, its synthesis attracted attention drug discovery development community. This book chapter will summarizes major synthetic methods currently used for preparation pharmacological significance such antifungal, antibacterial, antitubercular, anticancer, anti-inflammatory, antioxidant many more properties discussed. Furthermore, this comprise literature from 2020 till date

Language: Английский

Citations

0
Bacteria-triggered on-demand thymol release for salmon preservation: A self-destructive antibacterial strategy DOI
Yuhe Dong,

Xiao-Hui Jia,

Tong Tong Wu

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 485, P. 144563 - 144563

Published: April 29, 2025

Language: Английский

Citations

0
1,2,3-Triazole Containing Hybrids as Potential Pharmacological Agents: A Review DOI Open Access
Mir Mohammad Masood, Arshid Iqbal

Asian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 36(5), P. 983 - 1008

Published: April 30, 2024

1,2,3-Triazoles constitute a versatile class of nitrogen containing five-membered heterocycles, exhibiting wide range pharmacological properties which include antibacterial, antifungal, anticancer, antimalarial, antidiabetic, anti-inflammatory, antihypertensive and antioxidant, among various others. Medicinal chemists have been interested in this aromatic ring as framework since the inception click chemistry considered building block contemporary organic chemistry. Extensive research into framework’s linker characteristic has led to synthesis evaluation numerous 1,2,3-triazole hybrids bearing heterocyclic moieties potential leads for biological targets. This molecular hybridization also added advantage improved activity overcoming problem multiple drug resistance reduced toxicity. review summarizes activities conjugates, covering articles published past decade (2013 till date) will be great assistance medicinal researchers providing useful direction future discovery.

Language: Английский

Citations

1
Thymol and carvacrol against Klebsiella: anti-bacterial, anti-biofilm, and synergistic activities—a systematic review DOI Creative Commons

Kousha Farhadi,

Erta Rajabi, Hesam Aldin Varpaei

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 24, 2024

poses a significant global threat due to its high antibiotic resistance rate. In recent years, researchers have been seeking alternative antimicrobial agents, leading the introduction of natural compounds such as monoterpenes, specifically thymol and carvacrol. This review aims illustrate potential antimicrobial, anti-biofilm, synergistic traits carvacrol in combat against

Language: Английский

Citations

1
Synthesis and biological evaluation of novel 1,2,3-triazole hybrids of cabotegravir: identification of potent antitumor activity against lung cancer DOI Creative Commons
Yajie Guo,

Dan Sang,

Bin Guo

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 20, 2023

In pursuit of discovering novel anticancer agents, we designed and synthesized a series 1,2,3-triazole hybrids based on cabotegravir analogues. These compounds were subjected to initial biological evaluations assess their activities against non-small-cell lung cancer (NSCLC). Our findings indicated that some these exhibited promising antitumor abilities H460 cells, while demonstrated less efficacy H1299 cells. Notably, compound 5i emerged as the most potent, displaying an IC50 value 6.06 μM. Furthermore, our investigations into cell apoptosis reactive oxygen species (ROS) production revealed significantly induced triggered ROS generation. Additionally, Western blot analysis pronounced elevation LC3 expression in cells γ-H2AX subsequent treatment with 5i. molecular responses potentially contribute observed death phenomenon. highlight potential candidate for further development agent especially cancer.

Language: Английский

Citations

3
An overview of synthetic approaches and the potential bioactivity of different 1,2,3-triazole hybrids DOI Open Access
Wafaa A. Zaghary, Manal M. Anwar, Radwan El‐Haggar

et al.

Egyptian Pharmaceutical Journal, Journal Year: 2024, Volume and Issue: 23(2), P. 157 - 183

Published: Feb. 22, 2024

1,2,3-Triazole is considered to be the lead structure for discovery of many drug molecules. has received considerable attention in field due its remarkable widespread biological potential. This work summarizes current synthetic pathways adopted synthesis diverse analogs 1,2,3-triazole. It also introduces an overview latest advances 1,2,3-triazole hybrid models with various pharmacological activities, their chemical structures, structure–activity relationships, and mechanisms action.

Language: Английский

Citations

0