Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 40, P. 101839 - 101839
Published: Oct. 4, 2024
Language: Английский
Diabetology & Metabolic Syndrome, Journal Year: 2024, Volume and Issue: 16(1)
Published: June 16, 2024
Abstract Background Type 2 diabetes is an endocrine disorder characterized by compromised insulin sensitivity that eventually leads to overt disease. Adipose stem cells (ASCs) showed promising potency in improving type and its complications through their immunomodulatory differentiation capabilities. However, the hyperglycaemia of diabetic microenvironment may exert a detrimental effect on functionality ASCs. Herein, we investigate ASC homeostasis regenerative potential milieu. Methods We conducted data collection functional enrichment analysis differential gene expression profile MSCs microenvironment. Next, ASCs were cultured medium containing serum (DS) or normal non-diabetic (NS) for six days one-month periods. Proteomic was carried out, then evaluated apoptosis, changes surface markers DNA repair genes, intracellular oxidative stress, capacity. The crosstalk between determined pro anti-inflammatory cytokines cytokine receptors. Results differentially expressed genes points alteration stress regulating pathways MSCs. proteomic DS revealed proteins are related enhanced cellular damage altered potential. Our experiments confirmed these suffered defective repair. Under conditions, also osteogenic, adipogenic, angiogenic capacities. Both pro- significantly culture denoting Interestingly, induction antioxidative such as SIRT1, TERF1, Clusterin PKM2. Conclusion propose this deterioration function partially mediated induced inflammatory factors indicate adaptation mechanism increased
Language: Английский
Citations
1
Biomedical & Pharmacology Journal, Journal Year: 2024, Volume and Issue: 17(2), P. 1135 - 1148
Published: June 25, 2024
Traditional herbal remedies have an important role in human health. Empirically, Blumea balsamifera is often used as a traditional beverage to alleviate fever symptoms, lower cholesterol levels, and maintain body immunity. The purpose of this study was discover the phytoconstituent profile that contributes anti-diabetic properties B. leaf extract (BBLE) using silico approaches.LCMS/MS identify constituent BBLE, ability these compounds against diabetes-related proteins analyzed computationally.Three related diabetes are NF-KB p65, GLP-1, DPP-4. A total 18 were successfully identified through LCMS/MS, including 4 known be flavonoid derivatives can markers BBLE. Pheophorbide 1,1-Cyclopentanediacetic acid reported for first time inhibit DPP-4 docking simulation studies. Based on findings, it confirmed bioactive BBLE show strong inhibitory potential proteins.
Language: Английский
Citations
1
Journal of Traditional and Complementary Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: July 1, 2024
Ethanolic extract of Trichilia prieureana leaves have been reported to exhibit anti-hyperglycemic activities without detailed information on the anti-diabetic activities. This study investigated activity aqueous T. (AETPL) in type 2 diabetic (T2DM) male rats. T2DM rats (induced with 10 % fructose solution ad libitum for weeks and streptozotocin [STZ]; 40 mg/kg body weight {BW}) groups B, C, D, E, F were also administered distilled water (DW), metformin (100 BW), 11.2, 22.3, 44.6 BW AETPL, respectively, whilst non-diabetic Group A received DW only (Sham Control, SC) 14 days. The T2DM-related parameters then evaluated. fructose-fed streptozotocin-(FSTZ) treatment related significant (p < 0.05) increases FBS, HbA1c, fructosamine, HOMA-IR, G6P, GP, TC, TG, LDL-C, urea, bilirubin, hepatic pancreatic MDA levels; decreases BW, serum insulin, creatinine, albumin, HOMA-β, glycogen, G6PD, HK, HDL-C, SOD, GPX, RG, catalase, Hb, PCV, MCH, MCHC, MCV, RBC, WBC, differentials destruction β-cells, hepatocyte degeneration, central vein congestion reversed by values that compared well SC most cases. In IpGGT model, intraperitoneally AETPL reduced blood glucose elevated plasma insulin levels. at exhibited pronounced effects. (44.6 BW) restored T2DM-glycemic control associated biochemical changes via up-regulation carbohydrate metabolizing enzymes restoration histoarchitecture.
Language: Английский
Citations
1
Heliyon, Journal Year: 2024, Volume and Issue: 10(20), P. e38885 - e38885
Published: Oct. 1, 2024
Language: Английский
Citations
1
Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 40, P. 101839 - 101839
Published: Oct. 4, 2024
Language: Английский
Citations
1