Unlocking the therapeutic mechanism of Caesalpinia sappan: a comprehensive review of its antioxidant and anti-cancer properties, ethnopharmacology, and phytochemistry DOI Creative Commons
Estéfani Alves Asevedo, Lívia Ramos Santiago, Hyo Jeong Kim

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Herbal medicine are an invaluable reservoir of bioactive compounds, offering immense potential for novel drug development to address a wide range diseases. Among these, Caesalpinia sappan has gained recognition its historical medicinal applications and substantial therapeutic potential. This review explores the ethnopharmacological significance, phytochemical composition, pharmacological properties C. sappan, with particular focus on anticancer activities. Traditionally, been utilized treating respiratory, gastrointestinal, inflammatory conditions, demonstrating broad scope. The plant's rich array compounds-flavonoids, triterpenoids, phenolic acids, glycosides-forms basis potent antioxidant, anti-inflammatory, effects. Modern research further substantiated versatility, revealing anticancer, anti-diabetic, anti-infective, hepatoprotective properties. However, significant challenges remain, including need unravel precise molecular mechanisms underlying effects, refine extraction isolation methods validate safety efficacy through well-designed clinical trials. Particularly noteworthy is sappan's in combination therapies, where it may synergistically target multiple cancer pathways, enhance outcomes, mitigate adverse synthesizes findings from past decade, providing comprehensive evaluation promise while identifying critical areas future research. By addressing these gaps, could serve as cornerstone innovative strategies, hope improved management other complex

Language: Английский

Unlocking the therapeutic mechanism of Caesalpinia sappan: a comprehensive review of its antioxidant and anti-cancer properties, ethnopharmacology, and phytochemistry DOI Creative Commons
Estéfani Alves Asevedo, Lívia Ramos Santiago, Hyo Jeong Kim

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Herbal medicine are an invaluable reservoir of bioactive compounds, offering immense potential for novel drug development to address a wide range diseases. Among these, Caesalpinia sappan has gained recognition its historical medicinal applications and substantial therapeutic potential. This review explores the ethnopharmacological significance, phytochemical composition, pharmacological properties C. sappan, with particular focus on anticancer activities. Traditionally, been utilized treating respiratory, gastrointestinal, inflammatory conditions, demonstrating broad scope. The plant's rich array compounds-flavonoids, triterpenoids, phenolic acids, glycosides-forms basis potent antioxidant, anti-inflammatory, effects. Modern research further substantiated versatility, revealing anticancer, anti-diabetic, anti-infective, hepatoprotective properties. However, significant challenges remain, including need unravel precise molecular mechanisms underlying effects, refine extraction isolation methods validate safety efficacy through well-designed clinical trials. Particularly noteworthy is sappan's in combination therapies, where it may synergistically target multiple cancer pathways, enhance outcomes, mitigate adverse synthesizes findings from past decade, providing comprehensive evaluation promise while identifying critical areas future research. By addressing these gaps, could serve as cornerstone innovative strategies, hope improved management other complex

Language: Английский

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