Health
deterioration
and
the
increase
in
number
of
opportunistic
infections
require
search
for
safe
effective
means
combating
pathogens.
Acetic
acid
bacteria
(AAB)
are
constant
companions
lactic
(LAB)
yeasts
naturally
fermented
products
have
many
health
benefits.
However,
use
AAB
dairy
industry
is
limited.
Our
research
revealed
species
not
previously
noted
koumiss.
After
creating
associations
newly
isolated
LAB
AAB,
milk
beverage
was
created.
The
inclusion
Acetobacter
pasteurianus/oryzoeni
2-6
starter
Lactobacillus
delbrueckii
3KUM11
Streptococcus
thermophilus
3KUM12
provided
strong
anti-Candida
albicans
antagonism
significantly
increased
inhibition
intestinal
Gram-negative
with
simultaneous
shift
volatile
profile
towards
increasing
fatty
acids
but
affecting
sensory
properties.
When
Kluyveromyces
marxianus
19
included
composition
starter,
also
decreased
levels
alcohol
esters.
Frontiers in Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 5, 2024
The
imbalance
of
microbial
composition
and
diversity
in
favor
pathogenic
microorganisms
combined
with
a
loss
beneficial
gut
microbiota
taxa
results
from
factors
such
as
age,
diet,
antimicrobial
administration
for
different
infections,
other
underlying
medical
conditions,
etc.
Probiotics
are
known
their
capacity
to
improve
health
by
stimulating
the
indigenous
microbiota,
enhancing
host
immunity
resistance
infection,
helping
digestion,
carrying
out
various
functions.
Concurrently,
metabolites
produced
these
microorganisms,
termed
postbiotics,
which
include
compounds
like
bacteriocins,
lactic
acid,
hydrogen
peroxide,
contribute
inhibiting
wide
range
bacteria.
This
review
presents
an
update
on
using
probiotics
managing
treating
human
diseases,
including
complications
that
may
emerge
during
or
after
COVID-19
infection.
Foods,
Journal Year:
2024,
Volume and Issue:
13(4), P. 519 - 519
Published: Feb. 7, 2024
A
long-term
use
of
chemical
drugs
cannot
cure
type
II
diabetes
mellitus
(T2DM)
and
their
numerous
toxic
side
effects
can
be
harmful
to
human
health.
In
recent
years,
probiotics
have
emerged
as
a
natural
resource
replace
in
alleviating
many
ailments.
Healthy
children’s
intestines
lot
colonized
Lactobacilli
Bifidobacterium,
these
beneficial
bacteria
help
promote
overall
The
objective
this
study
was
isolate
potential
antidiabetic
probiotic
strains
from
healthy
children
evaluate
application
prospects.
Firstly,
Lactobacillus
Bifidobacterium
were
isolated
feces
identified
by
the
pheS
or
clpC
genes
with
respective
16S
rRNA
genes.
Then,
hydrophobicity,
artificial
gastrointestinal
fluid
tolerance,
α-Glucosidase
Dipeptidyl
peptidase
IV
(DPP-IV)
inhibitory
activities
determined,
antioxidant
promoting
secretion
GLP-1
STC-1
cells
candidate
tested.
Results
showed
that
6
obtained
aged
3
respectively,
including
Lacticaseibacillus
paracasei
L-21
L-25,
Levilactobacillus
brevis
L-16,
Lentilactobacillus
buchneri
L-9,
Lactiplantibacillus
plantarum
L-8
L-3,
bifidum
11-1
B-84,
longum
subsp.
6-1,
6-2,
B42
B53.
hydrophobicity
auto-aggregation
levels
all
higher
than
30%
50%,
decrease
number
colonies
less
2
log
CFU/mL.
Strains
L-8,
L-21,
11-1,
B53
B84
selected
based
on
high
α-glucosidase
activity
DPP-IV
activity,
results
capacity
assay
remaining
had
intense
comprehensive
activity.
Additionally,
B-53
most
substantial
prompting
effect
cell
line.
These
indicated
could
used
strain;
thus,
its
food
supplement
drug
ingredient
recommended
after
vivo
mitigation
test.
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(1), P. 265 - 265
Published: Jan. 5, 2025
Background:
Depression
often
coexists
with
anemia,
potentially
sharing
common
pathways,
highlighting
the
need
for
treatments
addressing
both
conditions
simultaneously.
This
study
evaluated
effect
of
probiotics
on
red
blood
cell
(RBC)
parameters
in
adults
depressive
disorder.
We
hypothesized
that
would
positively
influence
RBC
parameters,
modulated
by
baseline
inflammation
or
dietary
intake,
improved
function
correlating
better
antidepressant
outcomes.
Methods:
secondary
analysis
a
two-arm,
randomized,
double-blind,
controlled
trial
involved
116
Participants
received
probiotic
formulation
containing
Lactobacillus
helveticus
Rosell®-52
and
Bifidobacterium
longum
Rosell®-175
placebo
60
days.
Data
from
97
subjects
were
analyzed
including
hemoglobin
(HGB),
count,
hematocrit
(HCT),
mean
corpuscular
volume
(MCV),
concentration
(MCH),
(MCHC),
distribution
width
(RDW).
Results:
Probiotic
supplementation
did
not
result
significant
changes
compared
to
placebo.
However,
may
help
stabilize
HGB,
HCT,
MCH,
MCHC
levels,
preventing
fluctuations
observed
group.
Conclusions:
While
showed
potential
benefits
symptoms,
observed.
Larger
studies
are
needed
clarify
mechanisms
clinical
implications.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY,
Journal Year:
2025,
Volume and Issue:
75(1)
Published: Jan. 27, 2025
A
Gram-stain-positive,
facultatively
anaerobic,
rod-shaped
strain,
designated
SPB1-3
T
,
was
isolated
from
tree
bark.
This
strain
exhibited
heterofermentative
production
of
dl
-lactic
acid
glucose.
Optimal
growth
observed
at
25–40
°C,
pH
4.0–7.0,
and
in
the
presence
3%
(w/v)
NaCl.
The
cell
wall
peptidoglycan
contained
lysine
aspartic
acid.
predominant
fatty
acids
identified
were
C
16:0
Summed
feature
7
(C
19
:1
ω
7c/C
19:1
ω6
c
and/or
6c/
7c/19cy).
polar
lipid
profile
included
phosphatidylglycerol,
diphosphatidylglycerol
phosphatidylinositol,
along
with
two
unidentified
phospholipids,
amino
lipids
lipids.
Phylogenetic
analysis
based
on
16S
rRNA
gene
sequences
positioned
within
genus
Lentilactobacillus
showing
a
close
relation
to
kosonis
NBRC
111893
(99.86%)
curieae
CCTCC
M
2011381
(98.65%).
whole
genome
comprised
1
932
998
base
pairs
1955
coding
genes
DNA
G+C
content
37.8%.
Digital
DNA–DNA
hybridization
between
closely
related
type
strains
ranged
19.50
27.20%.
average
nucleotide
identity
84.21
85.56%,
57.25
85.99%,
both
falling
below
established
thresholds
for
species
delineation.
Strain
clearly
distinguishable
its
phenotypic
chemotaxonomic
characteristics,
sequence
similarity
analysis.
Additionally,
radical
scavenging
activity
66.92%
demonstrated
82.32%
inhibition
tyrosinase
inhibitory
assay.
These
findings
support
classification
as
novel
which
name
terminaliae
sp.
nov.
is
proposed.
(=JCM
35081
=TISTR
10005
).
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(2), P. 173 - 173
Published: Jan. 31, 2025
This
study
aimed
to
isolate
lactic
acid
bacteria
(LAB)
with
strong
antioxidant
activity
and
potential
probiotic
properties
from
yak
milk
dairy
products
in
the
Qinghai-Tibet
Plateau.
Initial
screening
of
isolates
was
performed
using
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
scavenging
assay
a
hydrogen
peroxide
tolerance
test.
Subsequently,
capacity
assessed
through
five
distinct
assays:
2,2'-azino-bis
(3-ethylbenzthiazoline)-6-sulfonic
(ABTS)
radical
ability,
superoxide
anion
hydroxyl
DPPH
assay,
reducing
assay.
The
strains
stronger
were
then
further
evaluated
for
their
properties.
Whole-genome
sequencing
conducted
on
Lactobacillus
plantarum
QL01.
Among
1205
isolates,
9
exhibited
capabilities.
Following
property
evaluation,
QL01
identified
as
safe
candidate
due
its
growth,
adhesion
resilience
acidic,
bile,
simulated
gastrointestinal
conditions.
Genome
analysis
revealed
that
most
QL01's
genes
involved
carbohydrate
metabolism.
Further
examination
antibiotic
resistance
virulence
factors
confirmed
safety,
meanwhile
linked
stress
responses
underscored
potential.
In
conclusion,
QL01,
strain,
successfully
isolated,
comprehensive
vitro
genomic
analyses.
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(5), P. 847 - 847
Published: Feb. 28, 2025
Background/Objectives:
The
skin,
being
the
body's
outermost
organ,
plays
a
vital
role
in
protecting
against
various
external
stimuli.
Ultraviolet
generates
reactive
oxygen
species
(ROS),
promoting
secretion
of
matrix
metalloproteinases
(MMPs)
and
inducing
collagen
degradation.
Many
studies
have
been
conducted
to
identify
natural
substances
that
can
prevent
or
delay
harmful
effects
UV.
Methods:
A
wound
healing
assay,
DCF-DA
(ROS)
JC-1
assay
were
performed
assess
bio-converted
eggplant
peels
(BEPs)
on
human
dermal
fibroblasts
(HDFs).
Western
blot
analysis
was
also
understand
underlying
mechanisms
for
their
effects.
Finally,
hematoxylin-eosin
staining
immunohistochemistry
animal
studies.
Results:
Our
study
evaluated
antioxidant
efficacy
BEPs
fermented
with
Lactobacillus
plantarum
hydrogen
peroxide
(H2O2)-HDFs
UVB-induced
skin
damage
hairless
mice.
We
demonstrated
exhibited
enhanced
properties
compared
non-fermented
(EPs).
facilitated
H2O2-damaged
HDFs,
reduced
ROS
levels,
restored
mitochondrial
membrane
potential.
suppressed
phosphorylation
ERK,
p38,
JNK
as
mechanism.
further
dietary
supplementation
downregulated
metalloproteinase
1
(MMP1)
expression
upregulated
I
(COL1)
UVB-damaged
mice,
indicating
more
effective
EPs.
Conclusions:
suggest
hold
significant
potential
protective
agent
mitigating
health.
