Protective Mechanisms of Vaginal Lactobacilli against Sexually Transmitted Viral Infections DOI Open Access
Elisa Avitabile, Laura Menotti,

Vanessa Croatti

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9168 - 9168

Published: Aug. 23, 2024

The healthy cervicovaginal microbiota is dominated by various Lactobacillus species, which support a condition of eubiosis. Among their many functions, vaginal lactobacilli contribute to the maintenance an acidic pH, produce antimicrobial compounds, and modulate host immune response protect against bacterial fungal infections. Increasing evidence suggests that these beneficial bacteria may also confer protection sexually transmitted infections (STIs) caused viruses such as human papillomavirus (HPV), immunodeficiency virus (HIV) herpes simplex (HSV). Viral STIs pose substantial public health burden globally, causing range infectious diseases with potentially severe consequences. Understanding molecular mechanisms exert protective effects viral paramount for development novel preventive therapeutic strategies. This review aims provide more recent insights into intricate interactions between STIs, exploring impact on microenvironment, response, infectivity pathogenesis, highlighting potential implications interventions clinical management

Language: Английский

Probiotics and Food Bioactives: Unraveling Their Impact on Gut Microbiome, Inflammation, and Metabolic Health DOI
Alice Njolke Mafe, Great Iruoghene Edo, Patrick Othuke Akpoghelie

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

Citations

7
A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses DOI Creative Commons
Alice Njolke Mafe, Great Iruoghene Edo,

Osamah S. Majeed

et al.

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

Citations

4
Impact of Metabolites from Foodborne Pathogens on Cancer DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3886 - 3886

Published: Dec. 1, 2024

Foodborne pathogens are microorganisms that cause illness through contamination, presenting significant risks to public health and food safety. This review explores the metabolites produced by these pathogens, including toxins secondary metabolites, their implications for human health, particularly concerning cancer risk. We examine various such as Salmonella sp., Campylobacter Escherichia coli, Listeria monocytogenes, detailing specific of concern carcinogenic mechanisms. study discusses analytical techniques detecting chromatography, spectrometry, immunoassays, along with challenges associated detection. covers effective control strategies, processing techniques, sanitation practices, regulatory measures, emerging technologies in pathogen control. manuscript considers broader highlighting importance robust policies, awareness, education. identifies research gaps innovative approaches, recommending advancements detection methods, preventive policy improvements better manage foodborne metabolites.

Language: Английский

Citations

10
Probiotic Functions in Fermented Foods: Anti-Viral, Immunomodulatory, and Anti-Cancer Benefits DOI Creative Commons
Yeonhee Pyo, Ki Han Kwon,

Yeon Ja Jung

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2386 - 2386

Published: July 28, 2024

Fermented foods can provide many benefits to our health. These are created by the action of microorganisms and help support digestive health immune system. include yogurt,

Language: Английский

Citations

8
The Impact of Probiotics on Oral Cancer: Mechanistic Insights and Therapeutic Strategies DOI Creative Commons

Lakshmi Nandhana S S,

D. Maheswary,

Sujith Sri Surya Ravi

et al.

Oral Oncology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100715 - 100715

Published: Jan. 1, 2025

Language: Английский

Citations

1
Exploring the Probiotic Potential of Bacteroides spp. Within One Health Paradigm DOI Creative Commons
Muhammad Aammar Tufail, Ruth A. Schmitz

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Abstract Probiotics are pivotal in maintaining or restoring the balance of human intestinal microbiota, a crucial factor mitigating diseases and preserving host’s health. Exploration into Bacteroides spp. reveals substantial promise their development as next-generation probiotics due to profound interaction with host immune cells capability regulate microbiome’s metabolism by significantly impacting metabolite production. These beneficial bacteria exhibit potential ameliorating various health issues such disorders, cardiovascular diseases, behavioral even cancer. Though it’s important note that high percentage them well opportunistic pathogens, posing risks under certain conditions. Studies highlight role modifying responses improving conditions regulating lymphocytes, controlling metabolism, preventing inflammation The safety efficacy strains currently scrutiny European Commission for authorization food processing, marking significant step towards commercialization. recent advancements bacterial isolation sequencing methodologies, coupled integration Metagenome-Assembled Genomes (MAGs) binning from metagenomics data, continue unveil spp., aiding broader understanding application these novel disease management.

Language: Английский

Citations

6
Alternative therapeutics to control antimicrobial resistance: a general perspective DOI Creative Commons
Biplab Singha, Vinayak Singh, Vijay Soni

et al.

Frontiers in Drug Discovery, Journal Year: 2024, Volume and Issue: 4

Published: July 17, 2024

Antimicrobial Resistance (AMR) is a critical global health challenge, and in this review article, we examine the limitations of traditional therapeutic methods emerging role alternative therapies. By examining reasons behind failure conventional treatments, including inadequacy one-drug-one-enzyme approaches, complex evolution AMR, impact drug biotransformation, better understand why treatments failed. Moreover, discusses several therapies, RNA-based aptamers, peptide-based phage therapy, probiotics, discussing their applications, advantages, limitations. Additionally, discuss obstacles to develop these funding shortages, regulatory barriers, public perception. This comprehensive analysis aims provide insight into future emphasizing need for innovative strategies practical approaches.

Language: Английский

Citations

5
Synergistic and off-target effects of bacteriocins in a simplified human intestinal microbiome: implications for Clostridioides difficile infection control DOI Creative Commons
Natalia S. Ríos Colombo, R. Paul Ross, Colin Hill

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 16, 2025

Clostridioides difficile is a major cause of nosocomial diarrhea. As current antibiotic treatment failures and recurrence infections are highly frequent, alternative strategies needed for the this disease. This study explores use bacteriocins, specifically lacticin 3147 pediocin PA-1, which have reported inhibitory activity against C. difficile. We engineered Lactococcus lactis strains to produce these bacteriocins individually or in combination, aiming enhance their Our results show that PA-1 display synergy, resulting higher anti-C. activity. then evaluated effects L. Simplified Human Intestinal Microbiome (SIHUMI-C) model, bacterial consortium eight diverse human gut species includes After introducing bacteriocin-producing into SIHUMI-C, samples were collected over 24 hours, genome copies each assessed using qPCR. Contrary expectations, combined increased levels despite showing synergy agar-based screening. can be rationally explained by antagonistic inter-species interactions within providing new insights how broad-spectrum antimicrobials might fail control targeted complex microbial communities. These findings highlight need mitigate off-target microbiomes when developing bacteriocin-based therapies with potential clinical implications infectious disease treatment.

Language: Английский

Citations

0
Fermentation of dehydrated fruit juices by L. plantarum with prebiotic supplementation as non-dairy functional beverages. DOI

Nurhazwani Sa’aid,

Joo Shun Tan

Process Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions DOI
Naveen Jeyaraman,

Madhan Jeyaraman,

Priya Dhanpal

et al.

World Journal of Experimental Medicine, Journal Year: 2025, Volume and Issue: 15(2)

Published: April 11, 2025

The gut microbiome, a complex ecosystem of microorganisms, has significant role in modulating pain, particularly within orthopaedic conditions. Its impact on immune and neurological functions is underscored by the gut-brain axis, which influences inflammation, pain perception, systemic responses. This integrative review examines current research how dysbiosis associated with various pathways, notably nociceptive neuroinflammatory mechanisms linked to central sensitization. We highlight advancements meta-omics technologies, such as metagenomics metaproteomics, deepen our understanding microbiome-host interactions their implications pain. Recent studies emphasize that gut-derived short-chain fatty acids microbial metabolites play roles neuroinflammation nociception, contributing management. Probiotics, prebiotics, synbiotics, faecal microbiome transplants are explored potential therapeutic strategies alleviate through modulation, offering an adjunct or alternative opioids. However, variability individual microbiomes poses challenges standardizing these treatments, necessitating further rigorous clinical trials. A multidisciplinary approach combining microbiology, immunology, neurology, orthopaedics essential develop innovative, personalized management rooted health, transform care.

Language: Английский

Citations

0