Journal of Dental Sciences, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Language: Английский
Citations
8
Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919
Published: Feb. 11, 2025
Language: Английский
Citations
6
Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3886 - 3886
Published: Dec. 1, 2024
Foodborne pathogens are microorganisms that cause illness through contamination, presenting significant risks to public health and food safety. This review explores the metabolites produced by these pathogens, including toxins secondary metabolites, their implications for human health, particularly concerning cancer risk. We examine various such as Salmonella sp., Campylobacter Escherichia coli, Listeria monocytogenes, detailing specific of concern carcinogenic mechanisms. study discusses analytical techniques detecting chromatography, spectrometry, immunoassays, along with challenges associated detection. covers effective control strategies, processing techniques, sanitation practices, regulatory measures, emerging technologies in pathogen control. manuscript considers broader highlighting importance robust policies, awareness, education. identifies research gaps innovative approaches, recommending advancements detection methods, preventive policy improvements better manage foodborne metabolites.
Language: Английский
Citations
11
Foods, Journal Year: 2024, Volume and Issue: 13(15), P. 2386 - 2386
Published: July 28, 2024
Fermented foods can provide many benefits to our health. These are created by the action of microorganisms and help support digestive health immune system. include yogurt,
Language: Английский
Citations
10
Oral Oncology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100715 - 100715
Published: Jan. 1, 2025
Language: Английский
Citations
1
Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 8, 2024
Abstract Probiotics are pivotal in maintaining or restoring the balance of human intestinal microbiota, a crucial factor mitigating diseases and preserving host’s health. Exploration into Bacteroides spp. reveals substantial promise their development as next-generation probiotics due to profound interaction with host immune cells capability regulate microbiome’s metabolism by significantly impacting metabolite production. These beneficial bacteria exhibit potential ameliorating various health issues such disorders, cardiovascular diseases, behavioral even cancer. Though it’s important note that high percentage them well opportunistic pathogens, posing risks under certain conditions. Studies highlight role modifying responses improving conditions regulating lymphocytes, controlling metabolism, preventing inflammation The safety efficacy strains currently scrutiny European Commission for authorization food processing, marking significant step towards commercialization. recent advancements bacterial isolation sequencing methodologies, coupled integration Metagenome-Assembled Genomes (MAGs) binning from metagenomics data, continue unveil spp., aiding broader understanding application these novel disease management.
Language: Английский
Citations
6
Frontiers in Drug Discovery, Journal Year: 2024, Volume and Issue: 4
Published: July 17, 2024
Antimicrobial Resistance (AMR) is a critical global health challenge, and in this review article, we examine the limitations of traditional therapeutic methods emerging role alternative therapies. By examining reasons behind failure conventional treatments, including inadequacy one-drug-one-enzyme approaches, complex evolution AMR, impact drug biotransformation, better understand why treatments failed. Moreover, discusses several therapies, RNA-based aptamers, peptide-based phage therapy, probiotics, discussing their applications, advantages, limitations. Additionally, discuss obstacles to develop these funding shortages, regulatory barriers, public perception. This comprehensive analysis aims provide insight into future emphasizing need for innovative strategies practical approaches.
Language: Английский
Citations
5
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9168 - 9168
Published: Aug. 23, 2024
The healthy cervicovaginal microbiota is dominated by various Lactobacillus species, which support a condition of eubiosis. Among their many functions, vaginal lactobacilli contribute to the maintenance an acidic pH, produce antimicrobial compounds, and modulate host immune response protect against bacterial fungal infections. Increasing evidence suggests that these beneficial bacteria may also confer protection sexually transmitted infections (STIs) caused viruses such as human papillomavirus (HPV), immunodeficiency virus (HIV) herpes simplex (HSV). Viral STIs pose substantial public health burden globally, causing range infectious diseases with potentially severe consequences. Understanding molecular mechanisms exert protective effects viral paramount for development novel preventive therapeutic strategies. This review aims provide more recent insights into intricate interactions between STIs, exploring impact on microenvironment, response, infectivity pathogenesis, highlighting potential implications interventions clinical management
Language: Английский
Citations
4
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(50), P. 27679 - 27700
Published: Nov. 26, 2024
The burgeoning field of microbiome research has profoundly reshaped our comprehension human health, particularly highlighting the potential probiotics and fecal microbiota transplantation (FMT) as therapeutic interventions. While benefits traditional are well-recognized, efficacy mechanisms remain ambiguous, FMT's long-term effects still being investigated. Recent advancements in high-throughput sequencing have identified gut microbes with significant health benefits, paving way for next-generation (NGPs). These NGPs, engineered through synthetic biology bioinformatics, designed to address specific disease states enhanced stability viability. This review synthesizes current on NGP stability, challenges delivery, their applications preventing treating chronic diseases such diabetes, obesity, cardiovascular diseases. We explore physiological characteristics, safety profiles, action various strains while also addressing opportunities presented by integration into clinical practice. NGPs revolutionize microbiome-based therapies improve outcomes is immense, underscoring need further optimize ensure safety.
Language: Английский
Citations
4
Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 16, 2025
Clostridioides difficile is a major cause of nosocomial diarrhea. As current antibiotic treatment failures and recurrence infections are highly frequent, alternative strategies needed for the this disease. This study explores use bacteriocins, specifically lacticin 3147 pediocin PA-1, which have reported inhibitory activity against C. difficile. We engineered Lactococcus lactis strains to produce these bacteriocins individually or in combination, aiming enhance their Our results show that PA-1 display synergy, resulting higher anti-C. activity. then evaluated effects L. Simplified Human Intestinal Microbiome (SIHUMI-C) model, bacterial consortium eight diverse human gut species includes After introducing bacteriocin-producing into SIHUMI-C, samples were collected over 24 hours, genome copies each assessed using qPCR. Contrary expectations, combined increased levels despite showing synergy agar-based screening. can be rationally explained by antagonistic inter-species interactions within providing new insights how broad-spectrum antimicrobials might fail control targeted complex microbial communities. These findings highlight need mitigate off-target microbiomes when developing bacteriocin-based therapies with potential clinical implications infectious disease treatment.
Language: Английский
Citations
0