Medicinal & Analytical Chemistry International,
Journal Year:
2024,
Volume and Issue:
8(1), P. 1 - 6
Published: Jan. 31, 2024
Pyrimidine,
having
two
nitrogen
atoms,
looks
like
pyridine
and
benzene.
In
nature,
pyrimidine
is
present
in
different
forms,
such
as
the
bases
of
DNA
RNA.
Due
to
its
structure,
various
kinds
biological
activity
have
been
observed.
The
substituted
fused
derivatives
were
chemically
synthesized
showed
anti-cancer
potential
against
cancer
cell
lines
(SW480,
A549,
CCRF-CEM,
THP-1,
HepG2,
HCT-116,
PC3,
Huh-7,
CNE-2,
MGC-803,
MDA-MB-435).
Based
on
experimental
results,
pyrimidines
remarkably
enhanced
anticancer
activity,
which
may
be
due
presence
Cl,
F,
Br,
CH3O,
aryl
urea,
indolyl
pyrimidine,
thienopyrimidine,
benzyl
amino
moiety.
this
article,
recent
research
findings
highlighted
Neurology International,
Journal Year:
2025,
Volume and Issue:
17(2), P. 26 - 26
Published: Feb. 7, 2025
Alzheimer’s
and
Parkinson’s
are
the
most
common
neurodegenerative
diseases
(NDDs).
The
development
of
aberrant
protein
aggregates
progressive
permanent
loss
neurons
major
characteristic
features
these
disorders.
Although
precise
mechanisms
causing
disease
(AD)
(PD)
still
unknown,
there
is
a
wealth
evidence
suggesting
that
misfolded
proteins,
accumulation
dysfunction
neuroreceptors
mitochondria,
dysregulation
enzymes,
release
neurotransmitters
significantly
influence
pathophysiology
diseases.
There
no
effective
protective
medicine
or
therapy
available
even
with
availability
numerous
medications.
an
urgent
need
to
create
new
powerful
bioactive
compounds
since
number
people
NDDs
rising
globally.
Heterocyclic
have
consistently
played
pivotal
role
in
drug
discovery
due
their
exceptional
pharmaceutical
properties.
Many
clinically
approved
drugs,
such
as
galantamine
hydrobromide,
donepezil
hydrochloride,
memantine
opicapone,
feature
heterocyclic
cores.
As
therapeutic
potential,
heterocycles
intriguing
research
topic
for
drugs
PD
AD.
This
review
aims
provide
current
insights
into
potential
use
targeting
diverse
targets
manage
potentially
treat
patients
AD
PD.
The Chemical Record,
Journal Year:
2023,
Volume and Issue:
23(12)
Published: Nov. 27, 2023
Cancer
stands
as
a
serious
malady,
posing
substantial
risks
to
human
well-being
and
survival.
This
underscores
the
paramount
necessity
explore
investigate
novel
antitumor
medications.
Nitrogen-containing
compounds,
especially
those
derived
from
natural
sources,
form
highly
significant
category
of
agents.
Among
these,
agents
with
six-membered
aromatic
nitrogen
heterocycles
have
consistently
attracted
attention
chemists
pharmacologists.
Accordingly,
we
present
comprehensive
summary
synthetic
strategies
clinical
implications
these
compounds
in
this
review.
entails
an
in-depth
analysis
synthesis
pathways
for
pyridine,
quinoline,
pyrimidine,
quinazoline.
Additionally,
historical
progression,
targets,
mechanisms
action,
effectiveness
small
molecule
inhibitors
possessing
structural
features.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(34), P. 24725 - 24740
Published: Jan. 1, 2024
In
this
report,
we
present
the
design
and
synthesis
of
a
novel
series
pyrimidine-tethered
spirochromane-based
sulfonamide
derivatives
aimed
at
combating
drug
resistance
in
malaria.
Compounds,
Journal Year:
2024,
Volume and Issue:
4(1), P. 186 - 213
Published: Feb. 27, 2024
The
thionamide
antithyroid
agents
were
discovered
largely
through
observations
carried
out
by
various
researchers
in
the
1940s
that
found
sulfhydryl-containing
substances
goitrogenic
animals.
Prof.
Edwin
B.
Astwood
started
using
these
drugs
to
treat
hyperthyroidism.
In
current
paper,
we
summarize
development
background
of
and
coordination
possibility
2-thiouracil
its
derivatives,
as
well
biological
activities
some
complexes.
Some
them
are
used
for
treatment
tuberculosis,
arthritis,
others
have
bactericidal
fungicidal
activity,
third
cytotoxic
properties,
could
be
types
cancer.
