Nano-bioceramics

Biological and medical physics series, Journal Year: 2025, Volume and Issue: unknown, P. 217 - 249

Published: Jan. 1, 2025

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An update on implication of POSS-based nanocomposites in bone tissue engineering: a review

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: Feb. 18, 2025

The science of Bone tissue engineering (TE) is quickly progressing. Engineering bone usually applications a synthetic extracellular matrix, cells or osteoblasts that can convert to osteoblasts, and adjusting causes boost adhesion, distinction, mineralized construction cells. Extremely porous scaffolds perform an important character in cell planting, propagation, fresh 3D-tissue construction. Reformative medicine track multi-disciplinary approach for the novel substances' development appliance, various defects therapy. presentation polyhedral oligomeric silsesquioxane (POSS) bio-polymeric scaffold has been shown develop biotic attributes hybrid combinations. This review focuses on influence POSS within Chitosan (CS), Hydroxyapatite (HA), zeolite matrixes, drawing, advantages limitations materials mentioned bone.

Language: Английский

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Neuralized and vascularized fast bone regeneration using recombinant humanized type 1 collagen and native bone composite inorganic salts

APL Materials, Journal Year: 2025, Volume and Issue: 13(3)

Published: March 1, 2025

Bone injury is a prevalent condition in clinical therapy that can lead to significant functional impairments and substantially disrupt the quality of life for patients. However, there has been limited breakthrough achieving neuralized vascularized rapid bone regeneration. In this study, we collaborated with recombinant humanized collagen 1 (rhCOL1), native composite inorganic salts (NBCISs), methacrylated silk fibroin (SilMA), marrow mesenchymal stem cells (BMSCs) construct biomimetic organic bio-mineralized multifunctional organoids repair defects, regeneration within just six weeks rabbits. We first determined optimal concentration SilMA (10%) by comprehensively evaluating crosslinking, operability, BMSC proliferation. The rhCOL1 NBCIS mixture was prepared using ratio 3:7, reference bone, subsequently added create biomineralized microenvironments NCSilMA. Similarly, proportions were optimized based on their effects compressive modulus, swelling, degradation. As result, successfully constructed hydrogel scaffold defect repair, characterized excellent biodegradability, appropriate strength, good biocompatibility, osteoinductive biological function. Finally, BMSC-loaded NCSilMA (organoids) achieved regeneration, up-regulated osteogenic genes enhanced cell colonization, collagen, polysaccharide deposition.

Language: Английский

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New Three Dimensional-Printed Polyethylene Terephthalate Glycol Liners for Hip Joint Endoprostheses: A Bioactive Platform for Bone Regeneration

Materials, Journal Year: 2025, Volume and Issue: 18(6), P. 1206 - 1206

Published: March 8, 2025

Osteoporosis and bone defects are commonly observed in postmenopausal women, often linked to decreased folic acid levels, which play a crucial role metabolism regeneration. This study investigates 3D-printed polyethylene terephthalate glycol (PETG)-based porous scaffolds impregnated with chitosan (CS), hydroxyapatite (HAp), (FA) for tissue engineering applications. The PETG-CS scaffold serves as the primary structural framework, HAp incorporated enhance bioactivity through its osteoconductive osteoinductive properties. FA was included address potential deficiencies quality stimulate cellular differentiation. were fabricated using precise 3D printing techniques, yielding structures controlled porosity. Physicochemical analyses confirmed successful integration of into matrix. Biological evaluations preosteoblast cell lines demonstrated enhanced viability, proliferation, biocompatibility scaffolds. These findings highlight promising applications PETG-CS-HAp-FA engineering, providing platform future investigations personalized regenerative therapies.

Language: Английский

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Effect of Hydrothermal Coatings of Magnesium AZ31 Alloy on Osteogenic Differentiation of hMSCs: From Gene to Protein Analysis

Materials, Journal Year: 2025, Volume and Issue: 18(6), P. 1254 - 1254

Published: March 12, 2025

An Mg-based alloy device manufactured via a superplastic forming process (Mg-AZ31+SPF) and coated using hydrothermal method (Mg AZ31+SPF+HT) was investigated as to increase mechanical osteointegration capability. The cell viability osteointegrative properties of alloy-derived Mg AZ31+SPF AZ31+SPF+HT extracts were regarding their effect on human mesenchymal stem cells (hMSCs) (maintained in basal (BM) osteogenic medium (OM)) after 7 14 days treatment. analyzed through metabolic activity double-strand DNA quantification, while the osteoinductive effects evaluated qRT-PCR, osteoimage, BioPlex investigations. Finally, preliminary liquid mass spectrometry analysis conducted secretome hMSCs. Biocompatibility revealed no toxic cells’ or proliferation during experimental period. A modulation observed osteoblast pre-commitment genes hMSCs treated with Mg-AZ31+SPF+HT OM, which supported by mineralization nodule analysis. investigation highlighted protein clusters involved extracellular exosomes, Hippo, lipid metabolism process. In conclusion, our results that can modulate canonical non-canonical vitro, suggesting possible application bone tissue engineering.

Language: Английский

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