Amniotic membrane, a novel bioscaffold in cardiac diseases: from mechanism to applications DOI Creative Commons
Hossein Rayat Pisheh, Ahmad Darvishi,

Seyed Saeid Masoomkhah

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 20, 2024

Cardiovascular diseases represent one of the leading causes death worldwide. Despite significant advances in diagnosis and treatment these diseases, numerous challenges remain managing them. One is need for replacements damaged cardiac tissues that can restore normal function heart. Amniotic membrane, as a biological scaffold with unique properties, has attracted attention many researchers recent years. This extracted from human placenta, contains growth factors, cytokines, other biomolecules play crucial role tissue repair. Its anti-inflammatory, antibacterial, wound-healing properties have made amniotic membrane promising option heart diseases. review article examines applications cardiovascular By focusing on mechanisms action this results clinical studies, an attempt will be to evaluate potential using Additionally, existing future prospects field discussed.

Language: Английский

Amnion-derived hydrogels as a versatile platform for regenerative therapy: from lab to market DOI Creative Commons
Golara Kafili, Hassan Niknejad,

Elnaz Tamjid

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 26, 2024

In recent years, the amnion (AM) has emerged as a versatile tool for stimulating tissue regeneration and been of immense interest clinical applications. AM is an abundant cost-effective source that does not face strict ethical issues biomedical The outstanding biological attributes AM, including side-dependent angiogenesis, low immunogenicity, anti-inflammatory, anti-fibrotic, antibacterial properties facilitate its usage engineering regenerative medicine. However, thin sheets accompanied by some limitations, such handling without folding or tearing necessity sutures to keep material over wound, which requires additional considerations. Therefore, processing decellularized (dAM) into temperature-sensitive hydrogel expanded processability applicability injectable minimally invasive therapies bioink fabrication biomimetic constructs recapitulating desired biochemical cues pre-defined architectural design. This article reviews multi-functionality dAM hydrogels various applications, skin repair, heart treatment, cartilage regeneration, endometrium vascular graft, dental pulp cell culture/carrier platform. Not only cutting-edge research reviewed but also available commercial products are introduced their main features shortcomings elaborated. Besides great potential AM-derived therapy, intensive interdisciplinary studies still required modify mechanical in order broaden therapeutic benefits Employing additive manufacturing techniques (e.g., bioprinting), nanotechnology approaches inclusion bioactive nanoparticles), alterations modification matrix with photo-sensitive molecules) particular interest. review aims discuss current function repair target tissues identifies innovative methods broadening applications nanomedicine healthcare.

Language: Английский

Citations

10
Unveiling the versatility of gelatin methacryloyl hydrogels: a comprehensive journey into biomedical applications DOI
Sheersha Pramanik, Majid Alhomrani, Abdulhakeem S. Alamri

et al.

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(4), P. 042008 - 042008

Published: May 20, 2024

Gelatin methacryloyl (GelMA) hydrogels have gained significant recognition as versatile biomaterials in the biomedical domain. GelMA emulate vital characteristics of innate extracellular matrix by integrating cell-adhering and metalloproteinase-responsive peptide motifs. These features enable cellular proliferation spreading within GelMA-based hydrogel scaffolds. Moreover, displays flexibility processing, it experiences crosslinking when exposed to light irradiation, supporting development with adjustable mechanical characteristics. The drug delivery landscape has been reshaped hydrogels, offering a favorable platform for controlled sustained release therapeutic actives. tunable physicochemical precise modulation kinetics release, ensuring optimal effectiveness. In tissue engineering, perform an essential role design scaffold, providing biomimetic environment conducive cell adhesion, proliferation, differentiation. Incorporating three-dimensional printing further improves its applicability developing complicated constructs spatial precision. Wound healing applications showcase bioactive dressings, fostering microenvironment regeneration. inherent biocompatibility provide efficiency closure wounds repair. stand at forefront innovation, addressing diverse challenges delivery, wound healing. This review provides comprehensive overview, in-depth understanding hydrogel's potential impact on progressing sciences.

Language: Английский

Citations

8
Supercritical Fluid‐Processed Multifunctional Hybrid Decellularized Extracellular Matrix with Chitosan Hydrogel for Improving Photoaged Dermis Microenvironment DOI Creative Commons
Seol‐Ha Jeong, Jimmy J.H. Kang,

Ki‐Myo Kim

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract To address the demand for reconstructive procedures in extensive subcutaneous tissue defects and significant dermis matrix loss, vascularized adipose regeneration is essential maintaining volume after material degradation. Accordingly, a double‐crosslinked hydrogel that combines polyethylene glycol (PEG)‐crosslinked carboxymethyl chitosan (CMC) with hybrid decellularized extracellular (dECM) developed. The dECM, sourced from porcine cardiac tissues, processed using supercritical fluid technique (scCO 2 ‐EtOH) retains 1.5–5‐fold more angiogenic adipogenic cytokines than traditional methods. This dECM‐based filler demonstrates excellent physical properties injectability, injection forces being significantly less crosslinked hyaluronic acid (HA) fillers. Upon incubation at 37 °C, storage modulus of fillers increases substantially, eventually enhancing their moldability additional crosslinking thermosensitive nature collagen. Assessments UVB‐induced photoaging mouse model indicate maintains superior shape stability, durability, supports regeneration, reduces inflammation, enhances VEGF expression ECM maturation effectively compared other These promising results suggest can serve as highly effective multifunctional solution injectable regenerative medical applications well‐suited potential clinical trials.

Language: Английский

Citations

0
Advances and impact of human amniotic membrane and human amniotic-based materials in wound healing application DOI
Parisa Heydari,

Maryam Mojahedi,

Pouya Javaherchi

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136596 - 136596

Published: Oct. 1, 2024

Language: Английский

Citations

1
Challenges in Application: Gelation Strategies of DAT-Based Hydrogel Scaffolds DOI
Qiaoyu Li, Wei Liang, Huiting Wu

et al.

Tissue Engineering Part B Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: April 26, 2024

Decellularized Adipose Tissue (DAT) has great clinical applicability, owing to its abundant source material, natural extracellular matrix (ECM) microenvironment, and non-immunogenic attributes, rendering it a versatile resource in the realm of tissue engineering. However, practical implementations are confronted with multifarious limitations. Among these, selection an appropriate gelation strategy serves as foundation for adapting diverse contexts. The crosslinking strategies under varying physical or chemical conditions exert profound influences on ultimate morphology therapeutic efficacy DAT. This review sums up processes DAT decellularization subsequent gelation, specific emphasis employed recent experimental applications expounds upon methodologies, underlying principles, implications different strategies, aiming offer insights inspiration application engineering advance research scaffold development.

Language: Английский

Citations

0
Hybrid thermosensitive hydrogel/amniotic membrane structure incorporating S-nitrosothiol microparticles: Potential use for controlled nitric oxide delivery DOI

Zahra Bagheri Azizabad,

Iman Shabani,

Azadeh Shabani

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124953 - 124953

Published: Nov. 1, 2024

Language: Английский

Citations

0
The impact of mechanical tuning on the printability of decellularized amniotic membrane bioinks for cell-laden bioprinting of soft tissue constructs DOI Creative Commons
Golara Kafili,

Elnaz Tamjid,

Abdolreza Simchi

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 29, 2024

Abstract Decellularized extracellular matrix (dECM) bioinks hold significant potential in the 3D bioprinting of tissue-engineered constructs (TECs). While allows for creation custom-designed TECs, development based solely on dAM, without inclusion supporting agents or chemical modifications, remains underexplored. In this study, we present concentration-dependent printability and rheological properties dAM bioinks, along with an analysis their vitro cellular responses. Our findings demonstrate that increasing concentrations, within range 1 to 3% w/v, enhances mechanical moduli enabling printing flat structures superior shape fidelity. assays reveal high cell viability across all bioink formulations; however, at tends impede fibroblast proliferation, resulting round morphology. We propose containing 2% w/v strike optimal balance, providing fine-resolved features a supportive microenvironment fibroblasts, promoting elongated spindle-like morphology enhanced proliferation. These results underscore importance concentration regulating performance particularly regarding morphology, successful soft tissues.

Language: Английский

Citations

0
Amniotic membrane, a novel bioscaffold in cardiac diseases: from mechanism to applications DOI Creative Commons
Hossein Rayat Pisheh, Ahmad Darvishi,

Seyed Saeid Masoomkhah

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 20, 2024

Cardiovascular diseases represent one of the leading causes death worldwide. Despite significant advances in diagnosis and treatment these diseases, numerous challenges remain managing them. One is need for replacements damaged cardiac tissues that can restore normal function heart. Amniotic membrane, as a biological scaffold with unique properties, has attracted attention many researchers recent years. This extracted from human placenta, contains growth factors, cytokines, other biomolecules play crucial role tissue repair. Its anti-inflammatory, antibacterial, wound-healing properties have made amniotic membrane promising option heart diseases. review article examines applications cardiovascular By focusing on mechanisms action this results clinical studies, an attempt will be to evaluate potential using Additionally, existing future prospects field discussed.

Language: Английский

Citations

0