Unveiling the Impact of COVID-19 on Ovarian Function and Premature Ovarian Insufficiency: A Systematic Review DOI Creative Commons
Charalampos Voros,

Despoina Mavrogianni,

Aspasia Minaoglou

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 407 - 407

Published: Feb. 7, 2025

Background/Objectives: Premature ovarian insufficiency (POI) is a disorder that affects women under the age of 40. It characterized by decreased function, elevated gonadotropin levels, and estradiol. SARS-CoV-2 disrupts function largely through oxidative stress, inflammation, immunological dysregulation, which are enhanced its entrance into tissues via ACE2 receptors. The purpose this comprehensive review was to investigate molecular pathways link infection POI analyze their consequences for reserve fertility. Methods: We searched databases such as PubMed, Scopus, EMBASE, Google Scholar papers published between 2020 2024. Eligible studies investigated effects on including hormonal indicators anti-Müllerian hormone (AMH) follicle-stimulating (FSH), oocyte quality, reserve. data were compiled complete examination molecules clinical findings. Increased inflammatory indicators, interleukin-6 NLRP3 inflammasome activation, impaired homeostasis. Anti-SARS-CoV-2 antibodies in follicular fluid could have quality. Observational showed transitory decreases AMH changed FSH levels following infection, with variable antral follicle count IVF results. Changes lipid profiles VEGF expression emphasized virus's influence angiogenesis microenvironment. Conclusions: impairs causing disruption, thereby increasing incidence POI. While most alterations temporary, long-term reproductive remain unknown. Continuous monitoring specific treatments required reduce risks associated COVID-19.

Language: Английский

The impact of COVID-19 on menstrual cycle’s alterations, in relation to depression and sleep disturbances: a prospective observational study in a population of medical students DOI Creative Commons
Daniela Polese,

Flavia Costanzi,

Paola Bianchi

et al.

BMC Women s Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 19, 2024

The sars-Cov-2 pandemic has determined psychological stress, particularly in the young population of medical students. We studied impact on menstrual cycle alteration relation to presence depression, sleep disturbances and post-traumatic a

Language: Английский

Citations

8
Unveiling the Impact of COVID-19 on Ovarian Function and Premature Ovarian Insufficiency: A Systematic Review DOI Creative Commons
Charalampos Voros,

Despoina Mavrogianni,

Aspasia Minaoglou

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 407 - 407

Published: Feb. 7, 2025

Background/Objectives: Premature ovarian insufficiency (POI) is a disorder that affects women under the age of 40. It characterized by decreased function, elevated gonadotropin levels, and estradiol. SARS-CoV-2 disrupts function largely through oxidative stress, inflammation, immunological dysregulation, which are enhanced its entrance into tissues via ACE2 receptors. The purpose this comprehensive review was to investigate molecular pathways link infection POI analyze their consequences for reserve fertility. Methods: We searched databases such as PubMed, Scopus, EMBASE, Google Scholar papers published between 2020 2024. Eligible studies investigated effects on including hormonal indicators anti-Müllerian hormone (AMH) follicle-stimulating (FSH), oocyte quality, reserve. data were compiled complete examination molecules clinical findings. Increased inflammatory indicators, interleukin-6 NLRP3 inflammasome activation, impaired homeostasis. Anti-SARS-CoV-2 antibodies in follicular fluid could have quality. Observational showed transitory decreases AMH changed FSH levels following infection, with variable antral follicle count IVF results. Changes lipid profiles VEGF expression emphasized virus's influence angiogenesis microenvironment. Conclusions: impairs causing disruption, thereby increasing incidence POI. While most alterations temporary, long-term reproductive remain unknown. Continuous monitoring specific treatments required reduce risks associated COVID-19.

Language: Английский

Citations

0