Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis DOI Creative Commons

Hang Pei,

Yanmin Zhang, Chao Wang

et al.

World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(7), P. 739 - 741

Published: July 25, 2024

Recently, we read an article published by the Yang

Language: Английский

Mesenchymal Stem Cell-Derived Exosomes as a Treatment Option for Osteoarthritis DOI Open Access

Anupama Vadhan,

Tanvi Gupta, Wen‐Li Hsu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9149 - 9149

Published: Aug. 23, 2024

Osteoarthritis (OA) is a leading cause of pain and disability worldwide in elderly people. There critical need to develop novel therapeutic strategies that can effectively manage improve the quality life for older Mesenchymal stem cells (MSCs) have emerged as promising cell-based therapy age-related disorders due their multilineage differentiation strong paracrine effects. Notably, MSC-derived exosomes (MSC-Exos) gained significant attention because they recapitulate MSCs into benefits without causing any associated risks compared with direct cell transplantation. These help transport bioactive molecules such proteins, lipids, nucleic acids, which influence various cellular processes related tissue repair, regeneration, immune regulation. In this review, we provided an overview MSC-Exos considerable treatment option osteoarthritis. This review will go over underlying mechanisms by may alleviate pathological hallmarks OA, cartilage degradation, synovial inflammation, subchondral bone changes. Furthermore, summarized current preclinical evidence highlighted results from vitro vivo studies, well progress clinical trials using treat OA.

Language: Английский

Citations

9
Exosomes in cartilage microenvironment regulation and cartilage repair DOI Creative Commons
Longfei Han,

Hou Wenyuan,

Weihua Fang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 5, 2025

Osteoarthritis (OA) is a debilitating disease that predominantly impacts the hip, hand, and knee joints. Its pathology defined by progressive degradation of articular cartilage, formation bone spurs, synovial inflammation, resulting in pain, joint function limitations, substantial societal familial burdens. Current treatment strategies primarily target pain alleviation, yet improved interventions addressing underlying are scarce. Recently, exosomes have emerged as subject growing interest OA therapy. Numerous studies investigated to offer promising therapeutic approaches for through diverse vivo vitro models, elucidating mechanisms which from various cell sources modulate cartilage microenvironment promote repair. Preclinical investigations demonstrated regulatory effects originating human cells, including mesenchymal stem cells (MSC), fibroblasts, chondrocytes, macrophages, derived Chinese herbal medicines, on modulation repair signaling pathways. Additionally, encompass matrix, proliferation migration autophagy, apoptosis, mitigation oxidative stress. An increasing number exosome carrier scaffolds under development. Our review adopts multidimensional approach enhance comprehension pivotal functions exerted sourced types OA. Ultimately, our aim pinpoint targets capable regulating facilitating

Language: Английский

Citations

0
Mesenchymal stromal/stem cell-derived exosomes as a potential therapeutic approach to osteoarthritis combined with type 2 diabetes mellitus DOI Creative Commons

Siyi Xie,

Meiling Liu,

Ya‐Jie Kong

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 27, 2025

Osteoarthritis (OA) and type 2 diabetes mellitus (T2DM) often coexist due to shared risk factors high prevalence, but effective treatment methods are currently lacking. Mesenchymal stromal/stem cell-derived exosomes (MSC-Exos) have regenerative properties that can repair cartilage damage, lower blood sugar levels, improve pancreatic β cell function, showing great potential in tissue repair. This review primarily explores the application of MSC-Exos OA T2DM, mechanisms MSC-Exos, therapeutic strategies engineered exosomes. Although MSC-Exo therapy shows promising potential, further research is needed validate its safety feasibility.

Language: Английский

Citations

0
The status and hotspot analysis of research on extracellular vesicles and osteoarthritis: a bibliometric analysis DOI Creative Commons

W. Zhang,

Wen Xiang,

Lin Yi

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 31, 2025

Degenerative joint disease, known as osteoarthritis (OA), is characterized by pain, swelling, and decreased mobility. The illness has a major negative influence on patients' quality of life common around the world, especially among older people. Nevertheless, there are insufficient possibilities for early diagnosis therapy. Extracellular vesicles, or EVs, control immune response, tissue healing, cellular communication. This work offers bibliometric representation areas focus correlations between extracellular vesicles osteoarthritis. We searched in publications Web Science Core Collection (WoSCC) database. Bibliometrics, an R package, CiteSpace 6.1. R2, VOSviewer 1.6.17 were used to perform analyses concentration fields, trends, relevant factors. 944 papers from 59 nations published; countries that contributed most field China, USA, Italy. Professors Laura Enrico top contributors. Sichuan University, Istituto Ortopedico Galeazzi, Shanghai Jiao Tong University three universities. International Journal Molecular Sciences excellent publication. Exosome, expression, knee osteoarthritis, vesicle, mesenchymal stem cell, inflammation often occurring keywords. These results suggest interest future research EVs OA. trend suggests volume literature OA will continue rise, with more being published future. study helps scholars understand current hotspots may inspire research.

Language: Английский

Citations

0
Regulation of ferroptosis in osteoarthritis and osteoarthritic chondrocytes by typical MicroRNAs in chondrocytes DOI Creative Commons
Qingyuan Yu, Yanan Xiao, Mengqi Guan

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 5, 2024

Osteoarthritis (OA) is a progressive degenerative disorder impacting bones and joints, worsened by chronic inflammation, immune dysregulation, mechanical stress, metabolic disturbances, various other contributing factors. The complex interplay of cartilage damage, loss, impaired repair mechanisms remains critical formidable aspect OA pathogenesis. At the genetic level, multiple genes have been implicated in modulation chondrocyte metabolism, displaying both promotive inhibitory roles. Recent research has increasingly focused on influence non-coding RNAs regulation distinct cell types within bone tissue OA. In particular, an expanding body evidence highlights regulatory roles microRNAs chondrocytes. This review aims to consolidate most relevant associated with chondrocytes, as identified recent studies, elucidate their involvement processes ferroptosis. Furthermore, this study explores interactions between long (lncRNAs) circular (circRNAs) OA, emphasis microRNA-mediated mechanisms. Finally, gaps current are identified, offering strategic insights advance understanding pathophysiology guide therapeutic developments field.

Language: Английский

Citations

2
Theophylline derivatives promote primordial follicle activation via cAMP-PI3K/Akt pathway and ameliorate fertility deficits in naturally aged mice DOI Creative Commons
Wenbo Zhang, Longwei Gao, Xiaodan Zhang

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(13), P. 5312 - 5329

Published: Jan. 1, 2024

In elderly women and patients with premature ovarian insufficiency (POI), activating their remaining dormant primordial follicles

Language: Английский

Citations

2
An Update on Emerging Regenerative Medicine Applications: The Use of Extracellular Vesicles and Exosomes for the Management of Chronic Pain DOI
William Shipman, Raquel Fonseca, Moises Dominguez

et al.

Current Pain and Headache Reports, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Language: Английский

Citations

2
From Bench to Bedside: The Role of Extracellular Vesicles in Cartilage Injury Treatment DOI Creative Commons
Pan Jin, Huan Liu,

Xichi Chen

et al.

Biomaterials Research, Journal Year: 2024, Volume and Issue: 28

Published: Jan. 1, 2024

Cartilage repair is the key to treatment of joint-related injury. However, because cartilage lacks vessels and nerves, its self-repair ability extremely low. Extracellular vesicles (EVs) are bilayer nanovesicles with membranes mainly composed ceramides, cholesterol, phosphoglycerides, long-chain free fatty acids, containing DNA, RNA, proteins (such as integrins enzymes). For mediating intercellular communication regulating mechanisms, EVs have been shown by multiple studies be effective options for repair. This review summarizes recent findings different sources (mammals, plants, bacteria) uses in repair, mechanisms captured injured chondrocytes, quantification storage EVs, which may provide scientific guidance promoting development field injury treatment.

Language: Английский

Citations

2
Additional comments on extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis DOI Creative Commons

Hang Pei,

Yanmin Zhang, Chao Wang

et al.

World Journal of Stem Cells, Journal Year: 2024, Volume and Issue: 16(7), P. 739 - 741

Published: July 25, 2024

Recently, we read an article published by the Yang

Language: Английский

Citations

0