Identification of immunostimulatory activities and active compounds from sequentially extracted fractions of rhizosphere fungal fermentation broth of Atractylodes macrocephala Koidz. rhizomes DOI Creative Commons

Yuxin Xie,

Na Lin,

Pingping Song

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 20, 2024

Pharmacological studies have shown that the rhizome of Atractylodes macrocephala Koidz. (Compositae), commonly known as atractylodes (AMR), can modulate immunity. Nevertheless, its resources been largely depleted, and pharmacological activity artificial AMR is relatively modest. We hypothesized fermented crude extracts rhizosphere fungi would similar immunomodulatory effects since metabolites generated by these are to those host plant given their long-term synergistic evolution.

Language: Английский

Investigating mechanisms of apoptosis of humic acid on Leishmania tropica: An in vitro and in silico approach. DOI Creative Commons
Mahsa Faramarzpour, Alireza Keyhani, Ehsan Salarkia

et al.

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e43017 - e43017

Published: March 1, 2025

Highlights•Humic acid (HA) demonstrated significant potential to trigger programmed cell death in Leishmania tropica-infected macrophages. This effect was observed through the probable modulation of both intrinsic and extrinsic apoptotic pathways.•HA combined with meglumine antimoniate (MA), revealed enhanced anti-leishmanial activity. The combination treatment exhibited a nearly additive effect, leading greater efficacy diminishing viability L. tropica parasites, particularly amastigote form, compared either alone.•Molecular docking assay indicated that HA binds beneficially key proteins, Bax Bcl2.•The study found also boosts antioxidative activities intra-macrophage amastigotes. suggests may eliminate oxidative stress, which is often elevated during leishmaniasis, thereby improving overall therapeutic profile against infection.•Generally, findings indicate humic could serve as promising agent for treating especially when used conventional treatments like antimoniate. emphasizes need further exploration HA's mechanisms its application animal studies.AbstractLeishmaniasis, parasitic neglected tropical disease, contributes remarkably global morbidity mortality. Current are facing multiple limitations, including side effects, drug resistance, high costs. Consequently, there pressing develop efficacious, widely accessible, lower-toxic compounds. Humic has previously shown potential, targeting apoptosis-related pathways cancerous infected cells. research structured investigate activity alone (MA) on infection. We employed molecular predict functional residues structural pockets Bcl2 proteins. Then, we conducted vitro assessments, protein expression analysis, immunocytochemistry profiles antioxidant mediators treated human Molecular binding interactions between Furthermore, more MA by inducing action, specifically apoptosis macrophages amastigotes modulating level proteins involved internal external assays. Notably, our results displayed can promote amastogites tropica. Thus, these vivo ex studies, antimonials.Graphical abstract

Language: Английский

Citations

1
Encapsulation of Citrus sinensis essential oil and R-limonene in lipid nanocarriers: A potential strategy for the treatment of leishmaniasis DOI
Jeferson da Silva dos Santos, Juliana Gouveia Galvão, Marcos Rafael das Chagas Mendonça

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124464 - 124464

Published: July 20, 2024

Language: Английский

Citations

4
Immunomodulatory activity of bamboo biosilica from Dendrocalamus longispathus Kurz. – Metabolomics integrated network pharmacology approach DOI
Amit Kar, Sayan Biswas, Barun Das Gupta

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 143, P. 156797 - 156797

Published: April 26, 2025

Language: Английский

Citations

0
Advance in Nrf2 Signaling Pathway in Leishmaniasis DOI Creative Commons
Sarmistha Saha, Nadezhda Sachivkina, Olga Kuznetsova

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2525 - 2525

Published: Nov. 4, 2024

One of the main components innate defense against invasive parasites is oxidative stress, which brought on by reactive oxygen species (ROS). On other hand, stressors serve two purposes: free radicals aid in elimination pathogens, but they can also set off inflammation, leads to tissue damage. Nuclear factor erythroid 2-related 2 (Nrf2) a transcription that controls expression numerous genes involved body's stress aging, damage, and pathological consequences. From cutaneous visceral forms,

Language: Английский

Citations

0
Identification of immunostimulatory activities and active compounds from sequentially extracted fractions of rhizosphere fungal fermentation broth of Atractylodes macrocephala Koidz. rhizomes DOI Creative Commons

Yuxin Xie,

Na Lin,

Pingping Song

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 20, 2024

Pharmacological studies have shown that the rhizome of Atractylodes macrocephala Koidz. (Compositae), commonly known as atractylodes (AMR), can modulate immunity. Nevertheless, its resources been largely depleted, and pharmacological activity artificial AMR is relatively modest. We hypothesized fermented crude extracts rhizosphere fungi would similar immunomodulatory effects since metabolites generated by these are to those host plant given their long-term synergistic evolution.

Language: Английский

Citations

0