Astrocyte marker GFAP in gliocytes of the peripheral nervous system DOI
Е. С. Петрова, E. A. Kolos

Российский физиологический журнал им  И  М  Сеченова, Journal Year: 2024, Volume and Issue: 110(9), P. 1277 - 1293

Published: Dec. 13, 2024

The study of peripheral nervous system glial cells is an actual problem modern neurobiology. purpose this work was to summarize our own and published data on the distribution fibrillary acidic protein (GFAP) in (PNS) cells. features GFAP expression enteric system, dorsal root ganglion nerve were examined. A comparative different populations PNS gliocytes led conclusion that intermediate filament distributed differently them. Analysis literature showed despite fact widely used as a molecular marker activation, there still no understanding exact mechanisms participation reactive response. described GFAP+gliocytes from parts demonstrate functional polymorphism protein. Its ability be expressed response injury requires further research.

Language: Английский

Effects of Supplementation with Microalgae Extract from Tetradesmus obliquus Strain Mi175.B1.a on Gastrointestinal Symptoms and Mental Health in Healthy Adults: A Pilot Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm Trial DOI Open Access

Sydnie A. Maltz,

Aaron T. Nacey,

Jonathan Maury

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 960 - 960

Published: March 10, 2025

Microalgae, a marine-derived natural ingredient, has emerged as rich source of bioactive compounds with the potential to modulate gut–brain axis activities. The objective this study was investigate whether supplementation microalgae extract from Tetradesmus obliquus strain Mi175.B1.a (TOME) influences gut health and reduces stress anxiety in healthy adults experiencing mild moderate gastrointestinal (GI) distress. Methods: Fifty-six (age: 31.9 ± 7.7 years; body weight: 71.8 12.6 kg; BMI: 24.6 2.8 kg/m2) were enrolled randomized, double-blind, placebo-controlled, parallel-arm clinical trial. Participants randomly allocated receive capsules containing either 250 mg/day TOME or placebo for four weeks. Primary outcomes included assessment GI symptoms using Gastrointestinal Symptom Rating Scale (GSRS) Bristol Stool (BSS). Secondary focused on subjective evaluation mood, stress, anxiety, well blood pressure responses sympathetic nervous system activation induced by cold pressor test (CPT). In addition, stool, plasma, saliva samples collected assess biomarkers associated activation, intestinal permeability, health. 16S rRNA sequencing performed analyze changes microbial populations. Results: Daily weeks safe tolerated population. significantly reduced GSRS global scores (p = 0.02), constipation 0.05) indigestion 0.03) subcomponent compared Placebo. There also significant increase Shannon’s index before FDR correction 0.05; 0.12) stool butyrate level lower group than Placebo after 4 0.039). Both groups showed reduction perceived scores, but intervention had Negative Affect < 0.001). plasma chromogranin A, biomarker, 0.03). no negative effects lipids other parameters related cardiovascular Conclusions: Overall, these results suggest that 4-week T. improves symptoms, potentially through microbiota, may promote positive mental Additional research should follow up populations increased mechanisms underlying improvements This trial registered at clinicaltrials.gov NCT06425094.

Language: Английский

Citations

0
Do enteric glial cells play a role in the pathophysiology of major depression? DOI Creative Commons
Ravi Philip Rajkumar

Exploration of neuroscience, Journal Year: 2024, Volume and Issue: 3(2), P. 156 - 174

Published: April 28, 2024

Major depressive disorder (MDD) is a common mental associated with significant suffering and disability. Recent evidence has highlighted the role of gut-brain axis in pathogenesis MDD. Enteric glial cells are structurally functionally diverse population that plays key regulating enteric nervous function maintaining intestinal mucosal integrity. These may be implicated origin several digestive extra-digestive disorders, known as neuro-gliopathies (ENG). This paper reviews MDD also belong to category ENG. Animal models suggest environmental adversity can lead dysfunction depressive-like behaviors. Conditions highly comorbid MDD, both extra-intestinal, have been linked alterations. Peripheral blood markers integrity altered patients certain treatments for beneficial effects on functioning. Though much this indirect provisional, it suggests group Further investigation functioning yield valuable insights into pathophysiology treatment disorder.

Language: Английский

Citations

1
Astrocyte Marker GFAP in Gliocytes of Peripheral Nervous System DOI
Е. С. Петрова, E. A. Kolos

Journal of Evolutionary Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 60(5), P. 1759 - 1771

Published: Sept. 1, 2024

Language: Английский

Citations

0
Astrocyte marker GFAP in gliocytes of the peripheral nervous system DOI
Е. С. Петрова, E. A. Kolos

Российский физиологический журнал им  И  М  Сеченова, Journal Year: 2024, Volume and Issue: 110(9), P. 1277 - 1293

Published: Dec. 13, 2024

The study of peripheral nervous system glial cells is an actual problem modern neurobiology. purpose this work was to summarize our own and published data on the distribution fibrillary acidic protein (GFAP) in (PNS) cells. features GFAP expression enteric system, dorsal root ganglion nerve were examined. A comparative different populations PNS gliocytes led conclusion that intermediate filament distributed differently them. Analysis literature showed despite fact widely used as a molecular marker activation, there still no understanding exact mechanisms participation reactive response. described GFAP+gliocytes from parts demonstrate functional polymorphism protein. Its ability be expressed response injury requires further research.

Language: Английский

Citations

0