Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(5), P. 597 - 597
Published: May 13, 2024
Oxidative
stress
occurs
when
there
is
an
imbalance
between
the
production
of
reactive
oxygen
species
(ROS)
and
body’s
antioxidant
defenses.
It
poses
a
significant
threat
to
physiological
function
reproductive
cells.
Factors
such
as
xenobiotics
heat
can
worsen
this
stress,
leading
cellular
damage
apoptosis,
ultimately
decreasing
efficiency.
The
nuclear
factor
erythroid
2–related
2
(Nrf2)
signaling
pathway
plays
crucial
role
in
defending
against
oxidative
protecting
cells
via
enhancing
responses.
Dysregulation
Nrf2
has
been
associated
with
infertility
suboptimal
performance
mammals.
Recent
advancements
therapeutic
interventions
have
underscored
critical
mitigating
restoring
functional
integrity
In
narrative
review,
we
delineate
harmful
effects
xenobiotic-induced
on
explain
how
provides
protection
these
challenges.
studies
shown
that
activating
using
various
bioactive
compounds
ameliorate
distress
apoptosis
mammalian
By
comprehensively
analyzing
existing
literature,
propose
key
target
for
caused
by
exposure
xenobiotic
stress.
Additionally,
based
synthesis
findings,
discuss
potential
therapies
focused
improve
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2025,
Volume and Issue:
39(5)
Published: April 28, 2025
ABSTRACT
Sulfasalazine,
an
anti‐inflammatory
drug
used
in
the
treatment
of
inflammatory
bowel
disorders
poses
a
threat
to
male
reproductive
potential.
With
growing
interest
therapeutic
ability
dietary
flavonoids
mitigate
drug‐related
dysfunction
males,
we
evaluated
possible
protective
potentials
quercetin
against
sulfasalazine‐induced
genotoxicity
bone
marrow
and
apoptosis
testis,
semen,
epididymis
Wistar
rats.
Twenty
rats
were
placed
into
four
groups
(
n
=
5)
orally
administered
following
for
14
consecutive
days:
Group
1:
0.5%
sodium
carboxymethyl
cellulose
(1
ml/kg).
2:
(20
mg/kg).
3:
sulfasalazine
(600
4:
mg/kg)
+
Tumor
suppressor
protein
(Tp53),
caspase
9,
3
levels
increased
while
TUNEL
positive
sperm
sulfasalazine‐treated
rats,
indicative
apoptotic
death
sperm.
These
significantly
decreased
co‐administered
with
quercetin.
However,
Tp53,
9
remained
unchanged,
TUNEL‐stained
cells
not
evident
testes
treated
sulfasalazine.
Again,
frequency
micronuclei
(MN)
its
genotoxic
MN
was,
however,
their
on
co‐administration
In
conclusion,
our
findings
suggest
that
holds
promise
ameliorating
associated
sulfasalazine's
detrimental
effect
fertility
DNA.
Natural Product Communications,
Journal Year:
2025,
Volume and Issue:
20(5)
Published: May 1, 2025
Objective
The
detrimental
effect
of
gamma
radiation
on
testicular
tissue
is
an
intricate
problem
in
the
field
nuclear
medicine.
Therefore,
this
study
aimed
to
investigate
potential
mechanism
carvacrol
against
toxicity
induced
by
γ-rays
based
bioinformatics
and
vivo
experiments.
Methods
targets
were
retrieved
from
SwissTargetPrediction
database.
In
addition,
for
radiation-induced
damage
identified
GeneCards
However,
common
identified.
Subsequently,
GO
KEGG
enrichment
was
conducted
using
KOBAS
server.
animals
vitro
experiment
used
validate
in-silico
analysis.
particular,
oxidative
stress
markers,
including
malondialdehyde
(MDA),
reduced
glutathione
(GSH),
total
antioxidant
status
(TAS),
superoxide
dismutase
(SOD),
catalase
(CAT),
as
well
testis
sperm
characteristics
serum
testosterone
level
examined
unveil
crucial
damage.
Results
findings
explored
that
markedly
increasing
oxidant
MDA,
substantially
decreasing
GSH,
TAS,
SOD,
CAT.
Additionally,
adversely
affected
levels.
bioinformatic
analyses
target
regulates
oxidation-reduction
biosynthesis
processes.
experimental
analysis
improved
stress.
Conclusion
revealed
could
reduce
γ-irradiated
rats
via
its
activity.
benefit
patients
receiving
radiotherapy.
Asian Pacific Journal of Reproduction,
Journal Year:
2024,
Volume and Issue:
13(5), P. 228 - 240
Published: Oct. 1, 2024
Objective:
To
investigate
the
potential
of
N
-acetylcysteine
(NAC)
and
zinc
sulphate
(ZnSO
4
)
in
mitigating
reproductive
dysfunction
caused
by
di-2-ethylhexyl
phthalate
(DEHP)
rats
to
understand
underlying
mechanisms,
specifically
oxidative
stress
sex
hormone
receptor
activity.
Methods:
Thirty-five
male
Wistar
were
randomly
divided
into
five
equal
groups
(
n
=7
per
group).
Group
1
was
administered
0.5
mL
distilled
water
served
as
control
group.
2
given
only
DEHP
(750
mg/kg/day),
while
group
3,
5
mg/kg/day)
plus
NAC
(100
ZnSO
(0.5
well
respectively.
All
treatments
lasted
for
21
days.
Samples
obtained
after
sacrificed,
hormones
levels
serum
markers
testicles
analyzed
using
enzyme-linked
immunosorbent
assay.
The
amount
androgen
receptors
determined
immunohistochemistry,
susceptibility
testosterone
bind
5α-reductase
molecular
docking
studies.
Results:
decreased
hormones,
testicular
antioxidant
enzymes,
increased
malondialdehyde
levels,
negatively
impacted
histology
pituitary
testes.
or
treatment
showed
a
marked
improvement
status
positive
effect
on
combination
both
appeared
be
more
effective.
affinity
may
lead
disruption
signaling,
which
can
further
result
related
androgen.
However,
is
likely
form
stronger
binding
interactions
with
follicle
stimulating
luteinizing
receptors,
gonadotropin-releasing
when
compared
DEHP.
Conclusions:
possibility
that
could
downregulate
DEHP-induced
changes
suggested
their
reduce
toxicity.
Advances in Clinical Toxicology,
Journal Year:
2024,
Volume and Issue:
9(2)
Published: Jan. 1, 2024
Cyclosporine
is
an
immunosuppressive
drug
that
widely
used
in
organ
transplantation
and
autoimmune
diseases.
However,
its
potential
reproductive
toxicity
male
animals
not
fully
understood.
This
mini-review
aims
to
provide
overview
of
the
current
knowledge
on
cyclosporine
animals,
focusing
effects
spermatogenesis,
sperm
quality,
fertility.
A
literature
search
was
conducted
using
PubMed,
Google
Scholar,
other
databases
identify
relevant
studies.
Studies
have
shown
can
various
adverse
spermatogenesis
including
decreased
production,
impaired
motility,
increased
abnormalities.
also
affect
quality
by
reducing
concentration,
viability,
DNA
integrity.
These
may
result
fertility
animals.
The
available
evidence
suggests
has
toxic
Further
research
needed
elucidate
mechanisms
action
develop
strategies
mitigate
these
effects.
