Mesenchymal Stem Cell Membrane‐Derived Composite System for Enhancing the Tumor Treatment Efficacy of Metal–Organic Framework Nanoparticles DOI Creative Commons
Ying Tong, Gao Meng, Ying‐Li Luo

et al.

IET Nanobiotechnology, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Mesenchymal stem cell (MSC) membrane‐coated metal–organic frameworks (MOFs) represent an innovative approach to enhance the uptake and therapeutic efficacy of copper‐based MOFs (Cu‐MOFs) in tumor cells. By leveraging natural homing abilities biocompatibility MSC membranes, Cu‐MOFs can be effectively targeted sites, promoting increased cellular uptake. This coating not only facilitates superior internalization by cancer cells but also augments outcomes due enhanced delivery copper ions. In vitro studies demonstrate that (MSC‐Cu‐MOFs) significantly improve cytotoxic effects on compared uncoated Cu‐MOFs. novel strategy presents a promising avenue for advancing precision effectiveness treatment modalities, showcasing potential clinical applications oncology.

Language: Английский

Inhibitory effect of organometallic framework composite nanomaterial ZIF8@ZIF67 on different pathogenic microorganisms of silkworms DOI
Zhenyu Shen, Samreen Sadiq, Tao Xu

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2025, Volume and Issue: unknown, P. 106307 - 106307

Published: Jan. 1, 2025

Language: Английский

Citations

0
Formation and evaluation of doxorubicin and cromoglycate metal–organic framework for anti-cancer activity DOI

Ebaa Abu Saleem,

Zainab Lafi, Naeem Shalan

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: Jan. 31, 2025

We develop and evaluate copper-based metal-organic frameworks (Cu-MOFs) incorporating cromolyn as a linker to enhance structural stability, drug delivery efficiency, therapeutic potential, particularly for breast cancer treatment. Two Cu-MOF formulations were synthesized: Cu-MOFs-BDC-DOX (using terephthalic acid) Cu-MOFs-CROMO-DOX linker). Characterization was performed using SEM/TEM morphology, FTIR, XRD, TGA confirm integrity. Drug encapsulation efficiency release profiles assessed, followed by in vitro cytotoxicity, cell migration, colony formation assays MDA-MB-231 cells. Both demonstrated high (83-91%) sustained over 48 h at pH 7.4. exhibited superior cytotoxicity with an IC50 of 0.88 ± 0.07 µM compared 7.1 0.11 Cu-MOFs-BDC-DOX. inhibit migration dose-dependent manner. The formulation enhanced outperforming its counterpart targeting This study highlights the promise MOF-based nanocarriers overcoming limitations conventional chemotherapy, offering pathway more effective targeted treatments reduced side effects.

Language: Английский

Citations

0
Effect of Nanofertilizers on Plant’s Stress-Tolerance DOI
Mohammad Mehdizadeh, Anahita Omidi, Duraid K. A. Al-Taey

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Advancement of Environment Friendly Emerging Lead‐Free Perovskite Solar Cell Materials and Its Devices DOI Open Access
Meenakshamma Ambapuram,

Adike Neeraja,

Raghavender Mitty

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(9)

Published: March 1, 2025

Abstract In the advancement of photovoltaic (PV) technology, perovskite solar cells (PSCs) have proven potential in their evolution and become vanguard research with an extraordinary power conversion efficiency (PCE) performance up to 26%, which stances a remarkable challenge thin film multi crystalline silicon (Si) technology. However, toxicity lead (Pb), stability issues etc., hampered commercialization cells. Scientists made efforts for development different categories lead‐free perovskites, including tin halide germanium‐based heterovalent elements (Transition metal perovskite, double perovskites etc.). corresponding devices is not mark, there are issues. The limitations mainly initiate from either unstable lattice structure these materials or low dimensionality (e.g., structural electronic dimensionality)‐related poor carrier transport self‐trapping effect, accelerating nonradiative recombination. This article reviews environmentally friendly PSCs developed by use novel, low/nontoxic materials, specific attention focused on assets identical pertinent production high PV devices, notable achievement reports all date performance, applications commercialization.

Language: Английский

Citations

0
Biogenic nanoparticles: Understanding their potential role in cancer theranostics DOI Creative Commons
Durdana Yasin,

Neha Sami,

Bushra Afzal

et al.

Next Nanotechnology, Journal Year: 2025, Volume and Issue: 8, P. 100149 - 100149

Published: Jan. 1, 2025

Language: Английский

Citations

0
Metal–organic framework MIL-101(Fe) functionalized with folic acid as a multifunctional nanocarrier for targeted chemotherapy–photodynamic therapy DOI
Eman Serag, Esmail M. El‐Fakharany, Sherif Hammad

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A novel folic acid-conjugated, iron-based metal framework MIL-101 (Fe) MOF loaded with 1,8-acridinediones (DO8) was developed for targeted photodynamic therapy (PDT).

Language: Английский

Citations

0
Impacts of designed vanillic acid-polymer-magnetic iron oxide nanocomposite on breast cancer cells DOI Creative Commons
Farahnaz Barahuie, Dena Dorniani, Bullo Saifullah

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(12), P. e32863 - e32863

Published: June 1, 2024

The engineered nano-vehicle was constructed using magnetic iron oxide nanoparticles (MIONs) and chitosan (CTS) to stabilize anticancer agent vanillic acid (VNA) which loaded on CTS-coated MIONs nanocarrier, more importantly, achieve sustained VNA release subsequent proper activity. new thermally stable VNA-CTS- nanocomposite spherical with a middle diameter of 6 nm had high drug loading about 11.8 %. resulting were composed pure magnetite therefore, superparamagnetic saturation magnetizations 53.3 45.7 emu.g−1, respectively. profiles from VNA-CTS-MIONs in different pH values showed controlled pH-responsive delivery the 89 % 74 percentage within 2354 4046 min at 5 7.4, respectively, as well accordance pseudo-second-order model. treatment diverse concentrations remarkably decreased viability promoted ROS accumulation apoptosis MDA-MB-231 breast cancer cells. Hence, it can be propitious candidate for management future.

Language: Английский

Citations

3
Molecularly imprinted polymer composite membranes: From synthesis to diverse applications DOI Creative Commons
Nasrullah Shah, Muffarih Shah, Touseef Rehan

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e36189 - e36189

Published: Aug. 1, 2024

This review underscores the fundamentals of MIP-CMs and systematically summarizes their synthetic strategies applications, potential developments. are widely acclaimed for versatility, finding applications in separation, filtration, detection, trace analysis, as well serving scaffolds a range analytical, biomedical industrial contexts. Also characterized by extraordinary selectivity, remarkable sensitivity, outstanding capability to bind molecules, those membranes also cost-effective, highly stable, configurable terms recognition and, therefore, inalienable various application fields. Issues relating future paper discussed last section with focus on improvement resource practical across different areas. Hence, this can be seen kind cookbook design fabrication an intention expand scope application.

Language: Английский

Citations

3
Metal–organic frameworks as nanoplatforms for combination therapy in cancer treatment DOI
Zainab Lafi, Sina M. Matalqah,

Ebaa Abu-Saleem

et al.

Medical Oncology, Journal Year: 2024, Volume and Issue: 42(1)

Published: Dec. 9, 2024

Language: Английский

Citations

3
Sustainable Waste Management in Orthopedic Healthcare Services DOI Open Access
Flaviu Moldovan, Liviu Moldovan

Sustainability, Journal Year: 2024, Volume and Issue: 16(12), P. 5214 - 5214

Published: June 19, 2024

It is estimated that globally medical surgical specialties, including orthopedics, produce large amounts of hospital waste. However, the possibilities recycling materials are not well highlighted. Orthopedic hospitals can collect larger volumes recyclables could be kept out landfills. The general objective this study to identify categories and related waste recyclable produced by main types interventions in orthopedics. specific evaluate preoperative intraoperative periods, but also their potential. For one month, we analyzed eight orthopedic interventions, which five were three nonsurgical. These performed at County Emergency Clinical Hospital Targu Mures Romania. was collected separately periods. Waste divided into recyclable, nonrecyclable, biological categories. bags weighed with a portable scale. results average per case interventions. secondary show biological, total To test for statistically significant differences between an analysis variance. Seventy-four cases included study. An amount 466.2 kg collected, mass 6.3 case. During period, 130.3 produced, 78% recyclable. 303.8 only 11% Trauma surgery largest waste, followed arthroplasty. A quarter greatest potential effectively recycled three-quarters. Through effective programs, ecological footprint orthopedic–traumatology reduced.

Language: Английский

Citations

2