BMC Gastroenterology,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Dec. 18, 2024
Several
studies
have
demonstrated
that
systemic
immune
inflammation
index
(SII)
has
a
positive
relationship
with
hepatic
steatosis.
However,
it
is
lack
of
system
evidence
for
the
correlation
between
SII
and
fibrosis.
The
objective
this
study
was
to
evaluate
relationships
steatosis
or
A
cross-sectional
analysis
performed
from
National
Health
Nutrition
Examination
Survey
(NHANES).
Fibrosis-4
(FIB-4),
NAFLD
fibrosis
score
(NFS)
hepamet
(HFS)
were
indicators
fibrosis;
fatty
liver
(FLI),
fat
(LFS)
Framingham
(FSI)
Pearson's
test,
generalized
linear
model
(GLM)
restricted
cubic
splines
(RCS)
used
analyze
associations
total
21,833
participants
enrolled
in
study.
test
GLM
revealed
there
negative
(FIB-4,
NFS
HFS),
while
(FLI,
LFS
FSI).
corresponding
β
(95%CI)
−
0.35(-0.46,
-0.24),
-0.67(-0.71,
-0.63)
0.10(-0.12,
-0.09),
respectively.
6.12(4.75,
7.50),
0.22(0.12,
0.31)
0.27(0.20,
0.34),
Statistically
significant
non-linear
association
found
RCS
(all
P
<
0.001).
There
fibrosis,
Lipids in Health and Disease,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 7, 2025
Nutrition
and
its
associated
inflammation
have
been
acknowledged
as
vital
factors
in
the
etiopathogenesis
of
non-alcoholic
fatty
liver
disease
(NAFLD)
fibrosis.
The
nutritional
risk
index
(NRI)
has
widely
recognized
a
valid
indicator
status
several
diseases,
including
osteoporosis
cardiovascular
disease.
However,
role
NRI
NAFLD
fibrosis
remains
unclear.
Participants
were
selected
from
National
Health
Examination
Survey
data
for
2017–2018
cycle.
Association
between
both
was
evaluated
using
multiple
logistic
regression
restricted
cubic
spline
(RCS)
analysis.
Mediation
analysis
employed
to
assess
influence
on
association
Compared
their
respective
control
groups,
individuals
with
exhibited
higher
levels.
Multiple
analyses
indicated
that
positively
odds
across
continuous
scales
quantile
adjustments
relevant
covariables.
RCS
model
demonstrated
dose-response
effect
NAFLD,
but
not
Receiver
operating
characteristic
(ROC)
revealed
area
under
ROC
curves
0.798
0.775
fibrosis,
respectively.
showed
accounted
3.139%
suggesting
might
partially
mediate
impact
NAFLD.
Our
findings
indicate
may
serve
potential
marker
these
underscoring
importance
etiopathogenesis.
Clinical and Experimental Medicine,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 15, 2025
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
chronic
disorder
closely
linked
to
metabolic
syndrome.
Identifying
novel,
easily
measurable
biomarkers
could
significantly
enhance
the
diagnosis
and
management
of
NAFLD
in
clinical
settings.
Recent
studies
suggest
that
immunoinflammatory
biomarkers—specifically,
neutrophil-to-lymphocyte
ratio
(NLR),
platelet-to-lymphocyte
(PLR),
lymphocyte-to-monocyte
(LMR)—may
offer
diagnostic
value
for
NAFLD.
However,
effectiveness
these
has
not
been
comprehensively
assessed
this
patient
population.
This
systematic
review
meta-analysis
aimed
evaluate
association
between
As
August
8,
2024,
databases
including
PubMed,
EMBASE,
Cochrane
Library,
Web
Science,
Scopus
were
systematically
searched
compare
NLR,
PLR,
LMR
levels
patients
healthy
controls.
Study
quality
was
using
Newcastle–Ottawa
Scale,
standardized
mean
differences
(SMDs)
with
95%
confidence
intervals
(CIs)
calculated
(PROSPERO
registry
number:
CRD42024580812).
A
total
20
included
meta-analysis.
Results
indicated
had
higher
NLR
(SMD
=
0.43;
CI
0.28–0.58;
p
<
0.001)
lower
PLR
−
0.29;
0.41
0.17;
compared
no
significant
difference
observed
controls(SMD
0.08;
0.00
0.051).
These
findings
may
hold
promise
as
markers
NAFLD,
while
appears
have
limited
utility.
Further
research
warranted
explore
potential
role
tracking
progression.
Renal Failure,
Journal Year:
2025,
Volume and Issue:
47(1)
Published: March 14, 2025
Background
Chronic
kidney
disease
(CKD)
prognosis
is
closely
tied
to
the
interplay
between
nutrition
and
inflammation.
However,
comprehensive
nutritional-inflammatory
indices
for
prognostic
evaluation
are
rare
in
CKD.
This
study
explored
association
of
advanced
lung
cancer
inflammation
index
(ALI)
with
estimated
glomerular
filtration
rate
(eGFR)
all-cause
mortality
CKD
patients.
Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: April 14, 2025
Background
The
advanced
lung
cancer
inflammation
index
(ALI)
is
a
composite
that
combines
and
nutritional
status,
non-alcoholic
fatty
liver
disease
(NAFLD)
associated
with
inflammation,
obesity.
This
study
aimed
to
investigate
the
possible
relationship
between
ALI
NAFLD.
Methods
We
extracted
cohort
datasets
from
2017–2020
National
Health
Nutrition
Examination
Survey
(NHANES)
for
study.
Weighted
analyses
multivariate
linear
regression
models
were
applied
assess
association
Fitted
curves
threshold
effects
used
characterize
nonlinear
relationships.
Results
A
total
of
6,595
adults
aged
18–80
years
included
in
this
In
analysis,
there
was
significant
positive
NAFLD
[OR:
1.02,
95%
CI
(1.01,
1.02)].
subgroup
analyses,
maintained
females
1.02)]
not
males.
addition,
we
found
nonlinear,
an
L-shaped
inflection
point
32.47.
showed
U-shaped
male
population,
40.65,
female
30.61.
Conclusion
Our
suggests
high
levels
prevalence
US
adult
population.
However,
more
clinical
studies
are
needed
confirm
finding.
Natural Product Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 10
Published: April 26, 2025
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
long-term
metabolic
condition
marked
by
unusual
fat
buildup
in
the
liver,
with
an
increasing
occurrence
worldwide.
Forsythoside
A
(FA),
bioactive
component
of
Forsythia
suspensa,
has
anti-inflammatory,
antioxidative,
and
hepatoprotective
effects.
This
study
investigates
mechanisms
which
FA
may
treat
NAFLD.
Using
bioinformatics
tools,
35
potential
targets
were
identified,
protein-protein
interaction
network
was
constructed.
KEGG
GO
enrichment
analyses
highlighted
important
pathways
associated
The
effects
confirmed
using
both
vitro
vivo
NAFLD
models.
Matrix
Metalloproteinase
9
(MMP9),
Tumour
Necrosis
Factor
Alpha
(TNFɑ),
identified
as
core
targets.
analysis
showed
that
affects
metabolic,
TNF
signalling,
insulin
resistance
pathways.
In
vivo,
reduced
lipid
accumulation
modulated
TNFɑ,
MMP9,
ALB
expression.
modulating
TNFɑ/MMP9/ALB
pathway,
providing
new
therapeutic
insights
for
treatment.
Journal of Gastroenterology and Hepatology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 11, 2024
Abstract
Background
and
Aim
This
study
aimed
to
investigate
the
relationship
between
advanced
lung
cancer
inflammation
index
(ALI)
non‐alcoholic
fatty
liver
disease
(NAFLD)
fibrosis
(AF).
Methods
A
total
of
5642
individuals
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2017
2020
were
examined.
Limited
cubic
spline
regression
model,
weighted
logistic
employed
determine
if
ALI
levels
related
prevalence
NAFLD
AF.
Additionally,
a
mediating
analysis
was
conducted
role
lipid
biomarkers,
such
as
cholesterol
(TC)
high‐density
lipoprotein
(HDL‐C),
in
effects
on
Results
After
adjusting
for
potential
confounders,
significant
positive
association
found
with
AF
prevalence.
Compared
those
Tertile
1,
participants
3
had
higher
odds
(odds
ratio
[OR]:
3.16;
95%
confidence
interval
[CI]:
2.52–3.97)
(OR:
3.17;
CI:
2.30–4.36).
Participants
both
2
lower
developing
(
P
trend
=
0.005).
Moreover,
we
discovered
nonlinear
NAFLD.
An
inflection
point
74.25
identified
through
two‐segment
linear
model.
TC
HDL‐C
mediated
by
10.2%
4.2%,
respectively
(both
<
0.001).
Conclusion
Our
findings
suggest
that
are
positively
associated
an
increased
AF,
partly
biomarkers.
World Journal of Gastroenterology,
Journal Year:
2024,
Volume and Issue:
30(40), P. 4393 - 4398
Published: Oct. 16, 2024
Liver
diseases
pose
a
significant
threat
to
human
health.
Although
effective
therapeutic
agents
exist
for
some
liver
diseases,
there
remains
critical
need
advancements
in
research
address
the
gaps
treatment
options
and
improve
patient
outcomes.
This
article
reviews
assessment
of
Elafibranor's
effects
on
fibrosis
intestinal
barrier
function
mouse
model
alcoholic
disease
(ALD),
as
reported
by
Koizumi
British Journal Of Nutrition,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 11
Published: Oct. 31, 2024
Abstract
While
previous
studies
have
identified
a
relationship
between
dietary
intake
and
the
risk
of
non-alcoholic
fatty
liver
disease
(NAFLD),
influence
overall
nutritional
status
on
NAFLD
development
has
not
been
thoroughly
investigated.
This
study
sought
to
explore
association
different
indicators
among
older
adults.
Nutritional
was
evaluated
using
controlling
(CONUT),
prognostic
index
(PNI)
(GNRI),
while
based
controlled
attenuation
parameter
≥
285
dB/m,
measured
transient
elastography.
The
analysis
included
multivariate
regression,
receiver
operating
characteristic
analysis,
eXtreme
Gradient
Boosting
subgroup
investigate
relationships
indices
NAFLD.
enrolled
1409
participants
for
main
with
an
prevalence
44·7
%.
After
accounting
potential
confounders,
positive
PNI
observed.
Participants
in
third
fourth
quartiles
showed
increased
odds
compared
lowest
quartile
(Q3:
OR
=
1·45,
95
%
CI
(1·03,
2·05);
Q4:
2·27,
(1·59,
3·24)).
Similarly,
higher
GNRI
were
significantly
associated
greater
(Q4
v
.
Q1:
aOR
1·84;
(1·28,
2·65)).
Conversely,
CONUT
values
linked
reduced
(OR
0·65,
(0·48,
0·87)).
highlights
that
suboptimal
status,
indicating
overnutrition
as
by
PNI,
CONUT,
is
positively
individuals
aged
50
years
above.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 18, 2024
Abstract
Background
Several
studies
have
demonstrated
that
systemic
immune
inflammation
index
(SII)
has
a
positive
relationship
with
hepatic
steatosis.
However,
it
is
lack
of
system
evidence
for
the
correlation
between
SII
and
fibrosis.
The
objective
this
study
was
to
evaluate
relationships
steatosis
or
Methods
A
cross-sectional
analysis
performed
21833
subjects
aged
over
20
from
National
Health
Nutrition
Examination
Survey
(NHANES).
Fibrosis-4
(FIB-4),
NAFLD
fibrosis
score
(NFS)
hepamet
(HFS)
were
indicators
fibrosis;
fatty
liver
(FLI),
fat
(LFS)
Framingham
(FSI)
Pearson’s
test,
generalized
linear
model
(GLM)
restricted
cubic
splines
(RCS)
used
analyze
associations
Results
test
GLM
revealed
there
negative
(FIB-4,
NFS
HFS),
while
(FLI,
LFS
FSI).
corresponding
β
(95%CI)
−
0.35(-0.46,
-0.24),
-0.67(-0.71,
-0.63)
0.10(-0.12,
-0.09),
respectively.
6.12(4.75,
7.50),
0.22(0.12,
0.31)
0.27(0.20,
0.34),
Statistically
significant
non-linear
association
found
in
RCS
(all
P
<
0.001).
Conclusion
There
fibrosis,
