A pan‐cancer analysis of the oncogenic and immunological roles of THOC3 in human cancer DOI Creative Commons
Jixin Zhang, Qi Zhao, Jidong Zhao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Background: There is a limited number of studies on THO Complex Subunit 3 (THOC3) in tumors. The purpose this study to conduct comprehensive analysis various types tumors determine the role THOC3 tumor progression and investigate its impact immunity. Methods. Retrieved expression data from cancers TCGA database analyzed it using R software (version 3.6.4) related packages; explored differential tumors, correlation with prognosis, functional enrichment, relationship heterogeneity. also aimed uncover between Results. THOC3 differentially expressed normal samples, correlated overall survival progression-free time. found that strongly associated mutational burden, microsatellite deletion, immune response. significantly cell infiltration, can regulate transcription output mRNA splicing. Therefore, we speculate could serve as therapeutic target for future anticancer therapies. Conclusions. may novel specific biomarker prognosis immunotherapy.

Language: Английский

Dual roles of myeloid-derived suppressor cells in various diseases: a review DOI
Mahesh R. Nepal,

S. P. Shah,

Kyu‐Tae Kang

et al.

Archives of Pharmacal Research, Journal Year: 2024, Volume and Issue: 47(7), P. 597 - 616

Published: July 1, 2024

Language: Английский

Citations

5
Single-cell mitophagy patterns within the tumor microenvironment modulate intercellular communication, impacting the progression and prognosis of hepatocellular carcinoma DOI Creative Commons

Zhengyan Li,

Wei Chen, Yao Shu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Hepatocellular carcinoma (HCC) is a common malignant tumor of the digestive system with high incidence that seriously threatens patients' lives and health. However, rise application new treatments, such as immunotherapy, there are still some restrictions in treatment diagnosis HCC, therapeutic effects on patients not ideal. Two single-cell RNA sequencing (scRNA-seq) datasets from HCC patients, encompassing 25,189 cells, were analyzed study. We utilized non-negative matrix factorization (NMF) clustering to identify mitophagy patterns TME including cancer-associated fibroblasts (CAFs), T B tumor-associated macrophages (TAMs). Cell-to-cell communication was using CellChat package, pseudotime trajectory analysis performed Monocle package. Gene regulatory networks investigated SCENIC survival analyses conducted mitophagy-related signatures. samples identified 22 clusters, 7 principal cell types. Complex communications observed among these Mitophagy-related CAFs, TAMs, CD8+ cells identified. These subtypes had different biological states, cell-cell communications, metabolic pathways. Mitophagy levels elevated samples. Changes genes within specific associated overall rates. did seem affect effectiveness immunotherapy. This study provides evidence modulates intercellular communication, influencing progression patient prognosis. Targeting may offer promising approach improve long-term prognosis patients.

Language: Английский

Citations

0
Improving the Wound Healing Process: Pivotal role of Mesenchymal stromal/stem Cells and Immune Cells DOI
Mahvash Sadeghi, Asma Moghaddam,

Amir Mohammad Amiri

et al.

Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

Citations

0
The role of innate immune cells in modulating vascular dynamics in skin malignancies DOI Creative Commons

Mateusz Marciniak,

Martyna Stachowicz-Suhs, Marek Wagner

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 189331 - 189331

Published: April 1, 2025

A developing tumor relies heavily on blood vessels to supply oxygen and nutrients. As a result, angiogenesis, the formation of new vessels, supports growth progression. Similarly, lymphangiogenesis, lymphatic plays critical role in metastatic dissemination by providing pathways for malignant cells spread. The microenvironment is crucial establishing maintaining these vascular networks, with innate immune playing key regulatory role. Notably, are specifically enriched barrier tissues, such as skin, emphasizing their importance skin malignancies Therefore, understanding regulating angiogenesis lymphangiogenesis essential novel therapeutic strategies. This review article explores how influence vasculature highlights potential that may arise from this knowledge.

Language: Английский

Citations

0
Exosome-based immunotherapy in hepatocellular carcinoma DOI Creative Commons
Zhihong Liu, Guowei Wang, Zhi Li

et al.

Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 24, 2025

Language: Английский

Citations

0
Role of FHOD1 in tumor cells and tumor immune microenvironment DOI Creative Commons
Yang Yang,

Zhanting Kang,

Jinlong Cai

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 29, 2025

FHOD 1 (Formin homology 2 domain containing protein 1) is a member of Diaphanous-related formins (DRFs) which contains GTP-binding (GBD), formin (FH) and FH domains, coiled-coil, diaphanous-like autoregulatory domain. Studies have shown that FHOD1 can not only regulate intracellular signals in tumor cells but also various components the microenvironment (TME), such as T cells, B cancer-associated fibroblasts (CAFs), some cytokines. Aberrant expression dysfunction play key role immunosuppression. Specifically, impair function chemokine receptors are supposed to direct immune localize site accurately. As result this impairment, cannot migrate efficiently into TME, thereby impairing their ability attack cells. In addition, activated signaling pathways within abnormally, resulting inability recognize destroy effectively. Therefore, ultimately leads state immunosuppression providing favorable conditions for growth spread Altogether review provides an in-depth understanding

Language: Английский

Citations

0
Fusobacterium nucleatum: a novel regulator of antitumor immune checkpoint blockade therapy in colorectal cancer DOI
Mengjie Luo, Qi Li,

Qingdan Gu

et al.

American Journal of Cancer Research, Journal Year: 2024, Volume and Issue: 14(8), P. 3962 - 3975

Published: Jan. 1, 2024

Neoadjuvant immune checkpoint blockade (ICB) has achieved significant success in treating various cancers, leading to improved therapeutic responses and survival rates among patients. However, colorectal cancer (CRC), ICB yielded poor results tumors that are mismatch repair proficient, microsatellite-stable, or have low levels of microsatellite instability (MSI-L), which account for up 95% CRC cases. The underlying mechanisms behind the lack response MSI-negative inhibitors remain an open conundrum. Consequently, there is urgent need explore intrinsic related biomarkers enhance intratumoral render tumor "immune-reactive". Intestinal microbes, such as oral microbiome member Fusobacterium nucleatum (

Language: Английский

Citations

1
Synthetic and biological nanoparticles for cancer immunotherapy DOI
Inês Oliveira, Paulo Rodrigues‐Santos, Lino Ferreira

et al.

Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(23), P. 5933 - 5960

Published: Jan. 1, 2024

Cancer is becoming the main public health problem globally. Conventional chemotherapy approaches are slowly being replaced or complemented by new therapies that avoid loss of healthy tissue, limit off-targets, and eradicate cancer cells. Immunotherapy nowadays an important strategy for treatment, uses host's anti-tumor response activating immune system increasing effector cell number, while, minimizing cancer's immune-suppressor mechanisms. Its efficacy still limited poor therapeutic targeting, low immunogenicity, antigen presentation deficiency, impaired T-cell trafficking infiltration, heterogeneous microenvironment, multiple checkpoints unwanted side effects, which could benefit from improved delivery systems, able to release immunotherapeutic agents tumor microenvironment Nanoparticles (NPs) immunotherapy (Nano-IT), have a huge potential solve these limitations. Natural and/or synthetic, targeted stimuli-responsive nanoparticles can be used deliver in their native conformations site interest enhance antitumor activity. They also as co-adjuvants activity IT These engineered natural context cell-derived extracellular vesicles (EVs) exosomes fully synthetic. In this review, detailed SWOT analysis done through comparison engineered-synthetic naturaly-derived terms current future use immunotherapy.

Language: Английский

Citations

1
Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer DOI Creative Commons
Xiangdong Liu, Wanqiu Zhang,

Shaozhong Wei

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 3, 2024

Colorectal cancer has emerged as one of the predominant malignant tumors globally. Immunotherapy, a novel therapeutic methodology, opened up new possibilities for colorectal patients. However, its actual clinical efficacy requires further enhancement. Copper, an exceptionally crucial trace element, can influence various signaling pathways, gene expression, and biological metabolic processes in cells, thus playing critical role pathogenesis cancer. Recent studies have revealed that cuproptosis, mode cell death, holds promise to become potential target overcome resistance immunotherapy. This shows substantial combination treatment Conveying copper into tumor cells via nano-drug delivery system induce cuproptosis could offer strategy eliminating drug-resistant vastly improving immunotherapy while ultimately destroy tumors. Moreover, combining induction with other anti-tumor approaches such photothermal therapy, photodynamic chemodynamic therapy enhance effect. review aims illuminate practical significance cuproptosis-inducing nano-drugs immunotherapy, scrutinize current challenges limitations this thereby providing innovative thoughts references advancement cuproptosis-based strategies.

Language: Английский

Citations

1
Innate immune response of host cells infected with Salmonella DOI Creative Commons

Hongfei Fan,

Juane Lu,

Hao Wu

et al.

BIO Web of Conferences, Journal Year: 2024, Volume and Issue: 111, P. 01022 - 01022

Published: Jan. 1, 2024

Salmonella is one of the most common pathogenic bacteria with a wide range hosts and can be transmitted by various routes, infecting animals humans causing gastrointestinal systemic diseases. The innate immune system acts as frontline defense against bacteria, triggering inflammatory antimicrobial responses coordinating multiple signaling pathways through host pattern recognition receptors. success infection largely dependent on host’s defense. This article reviews process response cells infected .

Language: Английский

Citations

0