Differential Regulatory Effects of Probiotics on Bone Metabolism by the Status of Bone Health and Delivery Route DOI Creative Commons
Chae Yeon Park,

Ok-Jin Park,

Yeongkag Kwon

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 28, 2024

Abstract Probiotics are known to have favorable effects on human health. Nevertheless, probiotics not always beneficial and can cause unintended adverse such as bacteremia and/or inflammation in immunocompromised patients. In the present study, we investigated of regulation bone metabolism under different health conditions delivery routes. Intragastric administration Lactiplantibacillus plantarum ovariectomized mouse models for mimicking post-menopausal osteoporosis humans substantially ameliorated by increasing mineral density. contrast, did occur normal healthy mice same condition. Interestingly, however, intraperitoneal L. induced destruction osteoclast differentiation decreasing osteoblast differentiation. Furthermore, when was implanted into calvarial bone, it potently augmented resorption. Concordantly, upregulated osteoclastogenesis downregulated osteoblastogenesis vitro experiments. These results suggest that distinct roles depending route.

Language: Английский

A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses DOI Creative Commons
Alice Njolke Mafe, Great Iruoghene Edo,

Osamah S. Majeed

et al.

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

Citations

6
Preventive and reparative potentials of heat-inactivated and viable commensal Bacillus pumilus SE5 in ameliorating the adverse impacts of high soybean meal in grouper (Epinephelus coioides) DOI

B Zhang,

Qing-Jie Nie,

Jian-Ming Xu

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 153, P. 109846 - 109846

Published: Aug. 19, 2024

Language: Английский

Citations

4
Evaluating the health risk of probiotic supplements from the perspective of antimicrobial resistance DOI Creative Commons

Qiwen Tian,

Hailv Ye,

Xuan Zhou

et al.

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

ABSTRACT Antimicrobial resistance remains a public health threat. Probiotics harboring antimicrobial resistant genes (ARGs) have, in recent years, been considered potential risk. Studies conducted on probiotics from increasingly popular supplements have raised the possibility of transmitting ARGs to commensals human gut, concomitantly establishing reservoir and risking acquisition by opportunistic pathogens. Building our previous study that reported multiple antibiotic supplements, this research, we attempted detect their may account for phenotypes. responsible tetracycline, macrolide, aminoglycoside, glycopeptide were prevalent probiotics. Through laboratory adaptive evolution studies, also show streptomycin-adapted gained erythromycin, doxycycline more effectively than non-adapted ones. When co-incubated with Enterococcus faecalis , Escherichia coli or Staphylococcus aureus Caco-2 and/or HCT-116 cells, streptomycin was transferred adapted generate transconjugants at frequencies comparable higher other studies through filter mating. Consistently, conferring ( aadA ) erythromycin [ erm(B)−1 ] detected E. S. transconjugants, respectively, after co-incubation cells. both transconjugant same Our data future comparative genomics metagenomics animal models healthy, immunocompromised, antibiotic-treated cohorts will contribute comprehensive understanding probiotic consumption, application, safety. IMPORTANCE are becoming popular, promising applications food medicine, but risk transferring disease-causing bacteria has concerns. drugs. Streptomycin-adapted antibiotics Importantly, showed could be intestinal resistance, which initially absent recipient bacteria, transconjugants. build foundation humans leveraging advanced approaches clarify long-term consumption.

Language: Английский

Citations

4
Evaluation of the safety and probiotic properties of Limosilactobacillus fermentum BGI-AF16, a uric acid-lowering probiotic strain DOI
Xilin Hou, Mengmeng Wang, Tongyuan Hu

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107382 - 107382

Published: Feb. 1, 2025

Language: Английский

Citations

0
Whole Genome Sequencing and In Silico Analysis of the Safety and Probiotic Features of Lacticaseibacillus paracasei FMT2 Isolated from Fecal Microbiota Transplantation (FMT) Capsules DOI

Amani Sliti,

Ryeong-Hui Kim,

Dokyung Lee

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107405 - 107405

Published: Feb. 1, 2025

Language: Английский

Citations

0
Gerobiotics: Exploring the Potential and Limitations of Repurposing Probiotics in Addressing Aging Hallmarks and Chronic Diseases DOI
A.G.M.Sofi Uddin Mahamud,

Ishtiak Ahammed Tanvir,

Md. Ehsanul Kabir

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

Citations

0
Enhancing human gut health: Global innovations in dysbiosis management DOI Creative Commons
Reda El Boukhari, Maima Matin, Latifa Bouissane

et al.

iMeta, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Language: Английский

Citations

0
Probiotics as a Treatment of Chronic Stress Associated Abnormalities DOI
Vipul Agarwal, Rishabh Chaudhary,

Anugya Gupta

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Language: Английский

Citations

0
Appraisal of postbiotics in cancer therapy DOI Creative Commons

Aruna Senthil Kumar Sudaarsan,

Asit Ranjan Ghosh

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 20, 2024

Cancer remains a multifactorial disease with an increased mortality rate around the world for past several decades. Despite advancements in treatment strategies, lower survival rates, drug-associated side effects, and drug resistance create need novel anticancer agents. Ample evidence shows that imbalances gut microbiota are associated formation of cancer its progression. Altering via probiotics their metabolites has gained attention among research community as alternative therapy to treat cancer. Probiotics exhibit health benefits well modulate immunological cellular responses host. Apart from probiotics, secreted products like bacteriocins, exopolysaccharides, short-chain fatty acids, conjugated linoleic acid, peptidoglycan, other found possess activity. The beneficiary role these postbiotic compounds is widely studied characterizing mechanism mode action reduces growth. present review mainly focuses on components employed against reported action. It also describes recent works carried out so far specific strain activity derived both vitro vivo , validating probiotic approach would pave way reduce burden

Language: Английский

Citations

2
Differential Regulatory Effects of Probiotics on Bone Metabolism by the Status of Bone Health and Delivery Route DOI Creative Commons
Chae Yeon Park,

Ok-Jin Park,

Yeongkag Kwon

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 28, 2024

Abstract Probiotics are known to have favorable effects on human health. Nevertheless, probiotics not always beneficial and can cause unintended adverse such as bacteremia and/or inflammation in immunocompromised patients. In the present study, we investigated of regulation bone metabolism under different health conditions delivery routes. Intragastric administration Lactiplantibacillus plantarum ovariectomized mouse models for mimicking post-menopausal osteoporosis humans substantially ameliorated by increasing mineral density. contrast, did occur normal healthy mice same condition. Interestingly, however, intraperitoneal L. induced destruction osteoclast differentiation decreasing osteoblast differentiation. Furthermore, when was implanted into calvarial bone, it potently augmented resorption. Concordantly, upregulated osteoclastogenesis downregulated osteoblastogenesis vitro experiments. These results suggest that distinct roles depending route.

Language: Английский

Citations

0