Perspective Chapter: Monocytes on the Interface of Metabolic Disorders and Colorectal Cancer DOI Creative Commons
Elena Kazakova, Irina Larionova, Tatiana Sudarskikh

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Colorectal cancer (CRC) is a prevalent malignancy with high incidence and mortality rates worldwide. Metabolic disorders, such as obesity, dyslipidemia, hyperglycemia, hypertension, have been identified significant risk factors contributing to the development progression of CRC. These metabolic conditions often result in low-grade inflammation, which plays crucial role tumor initiation progression. Monocytes, differentiate into tumor-associated macrophages (TAMs) within microenvironment (TME), are pivotal mediating these inflammatory responses. Monocytes individuals disorders exhibit altered phenotypes functions, enhancing their pro-inflammatory tumor-promoting activities. Our review describes intricate links between CRC on level circulating monocytes, highlighting how can drive aggravate via programming immunity. Various monocyte subsets, phenotypic changes, impact elucidated, providing insights potential therapeutic targets for prevention treatment. Understanding interplay alterations monocytes-derived TAMs TME essential developing effective strategies against

Language: Английский

Targeting of TAMs: can we be more clever than cancer cells? DOI Creative Commons
Julia Kzhyshkowska, Jiaxin Shen, Irina Larionova

et al.

Cellular and Molecular Immunology, Journal Year: 2024, Volume and Issue: 21(12), P. 1376 - 1409

Published: Nov. 8, 2024

АBSTRACT: With increasing incidence and geography, cancer is one of the leading causes death, reduced quality life disability worldwide. Principal progress in development new anticancer therapies, improving efficiency immunotherapeutic tools, personification conventional therapies needs to consider cancer-specific patient-specific programming innate immunity. Intratumoral TAMs their precursors, resident macrophages monocytes, are principal regulators tumor progression therapy resistance. Our review summarizes accumulated evidence for subpopulations number biomarkers, indicating predictive value clinical parameters carcinogenesis resistance, with a focus on solid cancers non-infectious etiology. We present state-of-the-art knowledge about tumor-supporting functions at all stages highlight recently identified by single-cell spatial analytical methods, that discriminate between tumor-promoting tumor-inhibiting TAMs, where both subtypes express combination prototype M1 M2 genes. focuses novel mechanisms involved crosstalk among epigenetic, signaling, transcriptional metabolic pathways TAMs. Particular attention has been given link cell metabolism epigenetic histone lactylation, which can be responsible unlimited protumoral Finally, we explain how interfere currently used therapeutics summarize most advanced data from trials, divide into four categories: inhibition TAM survival differentiation, monocyte/TAM recruitment tumors, functional reprogramming genetic enhancement macrophages.

Language: Английский

Citations

14
Immunometabolism of tumor-associated macrophages: a therapeutic perspective DOI Creative Commons

A. F. Karimova,

Adelya R. Khalitova,

Роман В. Суезов

et al.

European Journal of Cancer, Journal Year: 2025, Volume and Issue: unknown, P. 115332 - 115332

Published: Feb. 1, 2025

Language: Английский

Citations

1
Advances in the research of immunomodulatory mechanism of mesenchymal stromal/stem cells on periodontal tissue regeneration DOI Creative Commons

Dezhi Zhao,

Ruilin Yang,

Han-Xiao Wei

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

Periodontal disease is a highly prevalent worldwide that seriously affects people's oral health, including gingivitis and periodontitis. Although the current treatment of periodontal can achieve good control inflammation, it difficult to regenerate supporting tissues satisfactory therapeutic effect. In recent years, due tissue regeneration ability, research on Mesenchymal stromal/stem cells (MSCs) MSC-derived exosomes has been gradually deepened, especially its ability interact with microenvironment body in complex immunoregulatory network, which led many new perspectives strategies for diseases. This paper systematically reviews immunomodulatory (including bone immunomodulation) properties MSCs their role inflammatory microenvironment, summarizes pathways mechanisms by MSC-EVs have promoted lists potential areas future research, describes issues should be considered basic direction development "cell-free therapies" regeneration.

Language: Английский

Citations

0
Analysis of single-cell and spatial transcriptomics in TNBC cell-cell interactions DOI Creative Commons
Yan Xin,

Qiji Ma,

Qiang Deng

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 26, 2025

Triple-negative breast cancer (TNBC) is a highly malignant tumor in women, characterized by high morbidity, mortality, and recurrence rates. Although surgical treatment, radiotherapy, chemotherapy are the mainstays of current treatment methods, heterogeneity TNBC results unsatisfactory outcomes with low 5-year survival Rapid advancements omics technology have propelled understanding molecular biology. The emergence single-cell RNA sequencing (scRNA-seq) spatial transcriptomics (ST) has significantly enhanced knowledge distribution, functionality, intercellular interactions various cell types within microenvironment, including cells, T B macrophages, fibroblasts. present study provides an overview technical characteristics scRNA-seq ST, highlighting their applications exploring heterogeneity, distribution patterns, interactions. This review aims to enhance comprehension at cellular level for development effective therapeutic targets.

Language: Английский

Citations

0
Tumor Microenvironment On‐A‐Chip and Single‐Cell Analysis Reveal Synergistic Stromal–Immune Crosstalk on Breast Cancer Progression DOI Creative Commons
Kalpana Ravi, Yining Zhang,

Lydia Sakala

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Solid tumors develop within a complex environment called the tumor microenvironment (TME), which is sculpted by presence of other cells, such as cancer-associated fibroblasts (CAFs) and immune cells like macrophages (Mφs). Despite orchestrate tumor-supportive through intricate interaction with components TME. However, specific mechanism this intercellular dialogue regulated not fully understood. To that end, development an organotypic 3D breast TME-on-a-chip (TMEC) model, integrated single-cell RNA sequencing analysis, reported to mechanistically evaluate progression triple-negative cancer (TNBC) in patient-derived CAFs Mφs. Extensive functional assays, including invasion morphometric characterization, reveal synergistic influence Mφs on cells. Furthermore, gene expression pathway enrichment analyses identify involvement KYNU gene, suggesting potential evasion kynurenine pathway. Lastly, pharmacological targeting identified investigated.

Language: Английский

Citations

0
Bovine Meat and Milk Factor (BMMF) Protein Is Expressed in Macrophages Spread Widely over the Mucosa of Colorectal Cancer Patients DOI Creative Commons

Sumen Siqin,

Ekaterina Nikitina, Mohammad Rahbari

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 455 - 455

Published: March 19, 2025

Red meat consumption is considered a risk factor for colorectal cancer (CRC) development and stimulated isolation of plasmid-like DNA molecules from bovine serum milk, termed milk factors (BMMFs). BMMFs encode conserved replication protein (Rep). Increased populations Rep-expressing macrophages have been identified in the peritumor CRC patients pre-cancerous tissues when compared to healthy individuals. This supports concept that increase by indirect carcinogenesis, upon induction chronic inflammation. However, spread Rep+ immune cells at greater distances primary tumors has not yet assessed. Here, we immunohistologically analyzed presence sets tumor, and, additionally, distant (n = 13). We consistently high numbers BMMF-positive mucosal as much 25 cm away tumors, levels comparable peritumors associated with M2-like macrophage polarization. The broad distribution suggests BMMF+ might already exist stages dysplasia or before. Quantification BMMF tissue expression during colonoscopy help preventively stratify individuals developing polyps/CRC recommend them enhanced surveillance and/or changes dietary lifestyle.

Language: Английский

Citations

0
Stromal Fibrin Shapes Immune Infiltration Landscape of Pancreatic Ductal Adenocarcinoma DOI
Mazharul Karim, Md. Mahedi Hasan, Seung Hyun Kim

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123280 - 123280

Published: March 1, 2025

Language: Английский

Citations

0
Progress in reeducating tumor-associated macrophages in tumor microenvironment DOI Creative Commons
Yiming Zhao, Qianyang Ni,

Weijian Zhang

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 26, 2024

Abstract Malignant tumor, one of the most threatening diseases to human health, has been comprehensively treated with surgery, radiotherapy, chemotherapy and targeted therapy, but prognosis not always ideal. In past decade, immunotherapy shown increased efficacy in tumor treatment; however, for achieve its fullest potential, obstacles are be conquered, among which microenvironment (TME) widely investigated. remodeling immune inhibit progression, macrophages, as abundant innate population, play an irreplaceable role response. Therefore, how remodel TME alter recruitment polarization status tumor-associated macrophages (TAM) wide interest. this context, nanoparticles, photodynamic therapy other therapeutic approaches capable affecting macrophage have emerged. paper, we categorize organize existing means methods reprogramming TAM provide ideas clinical application novel tumor-related therapies.

Language: Английский

Citations

1
Perspective Chapter: Monocytes on the Interface of Metabolic Disorders and Colorectal Cancer DOI Creative Commons
Elena Kazakova, Irina Larionova, Tatiana Sudarskikh

et al.

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Colorectal cancer (CRC) is a prevalent malignancy with high incidence and mortality rates worldwide. Metabolic disorders, such as obesity, dyslipidemia, hyperglycemia, hypertension, have been identified significant risk factors contributing to the development progression of CRC. These metabolic conditions often result in low-grade inflammation, which plays crucial role tumor initiation progression. Monocytes, differentiate into tumor-associated macrophages (TAMs) within microenvironment (TME), are pivotal mediating these inflammatory responses. Monocytes individuals disorders exhibit altered phenotypes functions, enhancing their pro-inflammatory tumor-promoting activities. Our review describes intricate links between CRC on level circulating monocytes, highlighting how can drive aggravate via programming immunity. Various monocyte subsets, phenotypic changes, impact elucidated, providing insights potential therapeutic targets for prevention treatment. Understanding interplay alterations monocytes-derived TAMs TME essential developing effective strategies against

Language: Английский

Citations

0