The miraculous Asian fruit Baccaurea motleyana Müll. Arg. (Rambai): exploring the phyto‐pharmacological potentials of fruit peel through GC‐MS/MS, in vitro, in vivo and in silico approaches DOI Open Access

Saima Jahan Riti,

Suriya Akter Shompa, Hasin Hasnat

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

ABSTRACT Baccaurea motleyana Müll. Arg. (Rambai), an Asian fruit belonging to the Phyllanthaceae family, is cultivated throughout Southeast Asia and has been traditionally utilized in folk medicine address eye discomfort, digestive issues, insomnia, fevers. This study of peel employed four Kupchan fractions (PSF, DSF, ESF, ASF) obtained from methanol extract B. for vitro assessments, including antioxidant cytotoxicity antimicrobial activities. The crude was also used vivo evaluations, focusing on antidiarrheal antidepressant effects, complemented by phytochemical screening analysis using GC–MS/MS. investigation identified 20 phytochemicals, with primary constituents, phenol, 3,5‐bis(1,1‐dimethylethyl) (26.14%) 1‐heptadec‐1‐ynyl‐cyclohexanol (23.12%). exhibited potent activity (IC 50 : 9.43 µg/mL) (LC 6.01 µg/mL). most significant effect observed at a dosage 400 mg/kg. Molecular docking studies revealed that compounds, such as C9, C2, C19, displayed noteworthy binding affinities against glutathione reductase (−6.3 kcal/mol), urease oxidase (−6 monoamine A (−6.5 kcal/mol) receptors. In summary, our demonstrates fruits, like Rambai, could serve promising source therapeutics drug development countries.

Language: Английский

Phyto-pharmacological and computational profiling of Bombax ceiba Linn. Leaves revealed pharmacological properties against oxidation, hyperglycemia, pain, and diarrhea DOI Creative Commons
Mohammad Abdullah Taher, Md. Jamal Hossain,

Miss Sharmin Zahan

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35422 - e35422

Published: July 30, 2024

The present study aimed to conduct phytochemical and pharmacological profiling of methanolic crude extract leaves

Language: Английский

Citations

5
Chemico-pharmacological evaluations of the dwarf elephant ear (Colocasia affinis Schott) plant metabolites and extracts: health benefits from vegetable source DOI Creative Commons
Safaet Alam, Fahmida Tasnim Richi, Hasin Hasnat

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 13, 2024

Introduction: Colocasia affinis Schott (Family: Araceae), found in the Asian region, is a traditional root vegetable consumed by locals and well-known as Dwarf Elephant Ear. Methods: For pharmacological exploration of this vegetable, four kupchan fractions (i.e. HSF, DCMSF, EASF, AQSF) from ethanolic extract C. were employed to vitro i.e. antioxidant, cytotoxicity, antimicrobial vivo antidiarrheal analgesic assays, followed phytochemical screening GC-MS protocol. Result Discussion: In antioxidant assay, AQSF showed promising potential with an IC 50 value 29.4 μg/mL additionally, it exhibited greatest overall phenolic content, measuring 57.23 mg GAE/gm. among other fractions. The also revealed cytotoxic activity brine shrimp lethality assay LC 1.36 μg/mL. Both EASF substantial efficacy against both gram-positive gram-negative bacteria well various fungus species remarkable zone inhibitions compared standards. Whereas, during castor oil-induced acetic acid-induced writhing DCMSF at 400 mg/kg dose highest 51.16% reduction diarrhea 52.33% writhing. Phytochemical several chemical groups while study different dwarf elephant ear 48 bioactive phytochemicals total. Several targets such KAS, DHFR for anti-microbial activities, GLR, URO EGFR, BCL-2 KOR, DOR activities COX-2, TNF-α are considered molecular docking identified phytocompounds standards along ADME/T studies ascertain their safety, drug likeliness profiles. Conclusion: To recapitulate, our that vegetables can be prospective source therapeutics development besides nutritive food values.

Language: Английский

Citations

5
Antimicrobial and cytotoxicity evaluation of Annona muricata-based silver-cobalt nanoparticles on WEHI 164 cell line DOI Creative Commons
Anuoluwa Abimbola Akinsiku,

Ruth Opiotu Odaudu,

Oluwaseun Ejilude

et al.

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102230 - 102230

Published: April 1, 2025

Language: Английский

Citations

0
Unveiling the Therapeutic Potentials of Water Hyacinth (Eichhornia crassipes (Mart.) Solms) Flower against Oxidative Stress, Inflammation and Depressive Disorders: GC‐MS/MS, In Vitro, In Vivo and In Silico Approaches DOI
Hasin Hasnat,

Saima Jahan Riti,

Suriya Akter Shompa

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(12)

Published: Aug. 23, 2024

Abstract Water hyacinth ( Eichhornia crassipes (Mart.) Solms) is a highly invasive aquatic weed native to the Amazonia basin, known for its rapid propagation, adaptability, and utilization in traditional medicine. The study aims unveil therapeutic potential of water flowers methanolic extract (EC CME) four kupchan fractions PESF, EC DCMSF, EASF, ASF) through diversified chemical‐pharmacological approaches. GC‐MS/MS EC‐CME uncovered rich tapestry 72 phytochemical components. In vitro DPPH scavenging assay total phenolic content determination deciphered promising antioxidant assays with remarkably low IC 50 values 0.353 0.485 μg/mL, respectively EC‐ESF EC‐ASF. Besides, different vivo tests, including tail emersion, acetic acid‐induced writhing, thiopental‐induced sleeping test EC‐CME, yielded remarkable 8.61±0.29 min immersion time compared control's 2.05±0.11 at highest dose (600 mg/kg). best % inhibition writhing was recorded as 47.96 accrued 400 mg/kg dose, indicating robust pain‐relieving properties. onset duration sleep are significantly ameliorated unveiling antidepressant potential. molecular docking studies along ADME/T analysis also validated wet lab findings well their safety, efficacy, drug‐likeliness profile. Finally, this work can be an essential hint utilizing weeds drug development research.

Language: Английский

Citations

1
Unlocking the medicinal arsenal of Cissus assamica: GC‐MS/MS, FTIR, and molecular docking insights DOI Creative Commons
Mohammad Abdullah Taher,

Ripa Kundu,

Aysha Akter Laboni

et al.

Health Science Reports, Journal Year: 2024, Volume and Issue: 7(9)

Published: Sept. 1, 2024

Abstract Background and aims This study investigated the biochemical components present in leaves of Cissus assamica . The primary aim was to analyze these using advanced techniques assess their potential therapeutic applications. Methodology Fourier Transform Infrared (FT‐IR) spectroscopy, Gas Chromatography‐Mass Spectrometry (GC‐MS), Mass Spectral analysis were employed identify characterize compounds leaves. mass spectra each compound compared with data from Wiley NIST libraries determine names, molecular masses, chemical structures. FT‐IR identified characteristic functional groups by specific frequencies. Results discussion spectroscopic revealed significant vibrations at frequencies 3265.63, 2853.81, 1638.60, 1469.21, 1384.95 cm⁻¹, indicating presence groups. GC‐MS distinct compounds, such as “aR‐Turmerone,” “Curlone,” “7,8‐Epoxylanostan‐11‐ol, 3‐acetoxy‐,” “13‐Docosenamide, (Z)‐,” “Phenol, 3,5‐bis(1,1‐dimethylethyl)‐,” “9,19‐Cyclolanostan‐3‐ol, 24,24‐epoxymethano‐, acetate,” “Quinoline‐5,8‐dione‐6‐ol, 7‐[[(4‐cyclohexylbutyl)amino]methyl]‐.” These exhibited Their cytotoxic, antimicrobial, antidiarrheal, anti‐hyperglycemic, pain‐relieving properties evaluated comparing them reference ligands targeting receptors, including dihydrofolate reductase (DHFR), epidermal growth factor receptor (EGFR), kappa opioid (KOR), glucose transporter 3 (GLUT 3), cyclooxygenase 2 (COX‐2). Conclusion results this suggest that contain bioactive benefits for treating infections, diarrhea, hyperglycemia, pain. However, further research is needed conduct comprehensive phytochemical screening establish precise mechanisms action crude extract or plant‐derived compounds.

Language: Английский

Citations

1
Phyto-pharmacological wonders of genus Ficus: Ethnopharmacological insights and phytochemical treasures from natural products DOI Creative Commons
Hasin Hasnat, Safaet Alam, Suriya Akter Shompa

et al.

Saudi Pharmaceutical Journal, Journal Year: 2024, Volume and Issue: 32(12), P. 102211 - 102211

Published: Nov. 29, 2024

Language: Английский

Citations

0
The miraculous Asian fruit Baccaurea motleyana Müll. Arg. (Rambai): exploring the phyto‐pharmacological potentials of fruit peel through GC‐MS/MS, in vitro, in vivo and in silico approaches DOI Open Access

Saima Jahan Riti,

Suriya Akter Shompa, Hasin Hasnat

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

ABSTRACT Baccaurea motleyana Müll. Arg. (Rambai), an Asian fruit belonging to the Phyllanthaceae family, is cultivated throughout Southeast Asia and has been traditionally utilized in folk medicine address eye discomfort, digestive issues, insomnia, fevers. This study of peel employed four Kupchan fractions (PSF, DSF, ESF, ASF) obtained from methanol extract B. for vitro assessments, including antioxidant cytotoxicity antimicrobial activities. The crude was also used vivo evaluations, focusing on antidiarrheal antidepressant effects, complemented by phytochemical screening analysis using GC–MS/MS. investigation identified 20 phytochemicals, with primary constituents, phenol, 3,5‐bis(1,1‐dimethylethyl) (26.14%) 1‐heptadec‐1‐ynyl‐cyclohexanol (23.12%). exhibited potent activity (IC 50 : 9.43 µg/mL) (LC 6.01 µg/mL). most significant effect observed at a dosage 400 mg/kg. Molecular docking studies revealed that compounds, such as C9, C2, C19, displayed noteworthy binding affinities against glutathione reductase (−6.3 kcal/mol), urease oxidase (−6 monoamine A (−6.5 kcal/mol) receptors. In summary, our demonstrates fruits, like Rambai, could serve promising source therapeutics drug development countries.

Language: Английский

Citations

0