Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines
Life,
Journal Year:
2024,
Volume and Issue:
14(8), P. 1037 - 1037
Published: Aug. 20, 2024
The
objective
of
this
study
was
to
evaluate
the
antioxidant,
anti-inflammatory,
and
anticancer
properties
thymol,
carvacrol,
their
equimolar
mixture.
Antioxidant
activities
were
assessed
using
DPPH,
ABTS,
ORAC
methods.
thymol/carvacrol
mixture
exhibited
significant
synergism,
surpassing
individual
compounds
ascorbic
acid
in
DPPH
(IC
Language: Английский
Inhibition of carbohydrate digestive enzymes by a complementary essential oil blend: in silico and mixture design approaches
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 10, 2025
Background
The
increasing
demand
for
natural
alternatives
in
diabetes
treatment
has
driven
research
into
plant-derived
metabolites,
particularly
essential
oils
(EOs)
with
bioactive
properties.
This
study
aims
to
optimize
an
EO
mixture
inhibiting
two
key
enzymes
involved
glucose
digestion:
pancreatic
α-amylase
and
intestinal
α-glucosidase.
Methods
Essential
were
extracted
from
three
Moroccan
medicinal
plants:
false
yellowhead
(
Inula
viscosa
L.),
rose
geranium
Pelargonium
graveolens
L'Hér.),
lemongrass
Cymbopogon
citratus
(DC.)
Stapf.).
Gas
chromatography-mass
spectrometry
(GC-MS)
analysis
identified
metabolites
each
EO.
A
statistical
design
was
employed
evaluate
different
ratios
their
inhibitory
effects
on
Additionally,
density
functional
theory
(DFT)
calculations
molecular
docking
simulations
conducted
assess
the
metabolites'
electronic
properties
interaction
potential
target
enzymes.
Results
GC-MS
32
P
.
,
citronellol
(18.67%),
eucalyptol
(13.30%),
2-octen-1-ol
(8.12%)
as
major
components.
I
contained
18
dominated
by
2-camphanol
acetate
(51.12%)
camphol
(19.32%),
while
C.
had
23
α-citral
(24.70%)
2-isopropenyl-5-methylhex-4-enal
(29.25%)
constituents.
optimal
formulation
α-glucosidase
inhibition
a
binary
of
73%
27%
P.
In
contrast,
best
blend
consisted
56%
44%
I.
DFT
confirmed
electrophilic
nature
supporting
enzyme
interaction.
Molecular
suggested
that
these
phytochemicals
could
exhibit
stronger
than
acarbose,
widely
used
antidiabetic
drug.
Conclusion
These
findings
highlight
optimized
formulations
managing
hyperglycemia
developing
novel
therapies.
Language: Английский
Enhanced Antioxidant and Antimicrobial Activity through mixture design predictive modelling of an Essential Oil Blend from Syzygium aromaticum, Zingiber officinale, and Cananga odorata of Comoros Islands
Djanah-Karene Nacer-Eddine,
No information about this author
El Hassania Loukili,
No information about this author
Sara Lebrazi
No information about this author
et al.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Abstract
Medicinal
and
aromatic
plants
from
the
Comoros
Islands
are
a
potential
source
of
unexploited
bioactive
compounds.
This
study
investigates
chemical
composition
biological
properties
essential
oils
(EOs)
three
emblematic
Comorian
plants:
Syzygium
aromaticum
(L.)
Merr.
&
L.M.Perry
(clove),
Cananga
odorata
(Lam.)
Hook.
f.
Thomson
(ylang-ylang),
and
Zingiber
officinale
Roscoe
(ginger).
EOs
were
characterized
using
gas
chromatography
coupled
with
mass
spectrometry
(GC-MS).
Antioxidant
activities
evaluated
DPPH
molybdenum-reducing
power
methods,
while
antimicrobial
determined
by
microdilution
method
against
various
pathogenic
strains.
A
mixture
design
was
applied
to
optimize
EO
combinations,
identifying
significant
synergies
in
their
activities.
GC-MS
analysis
revealed
that
major
compounds
S.
aromaticum
cinnamal
(53.23%),
eucalyptol
(16.37%),
camphene
(9.74%),
Z.
officinale
α-zingiberene
(19.33%),
β-citral
(12.93%),
β-cymene
(7.16%),
C.
odorata
contained
primarily
o-cresol
(14.09%),
germacrene
D
(11.16%),
β-linalool
(10.47%).
Mixture
optimization
combination
EOs
significantly
enhanced
antioxidant
activity
(DPPH
assay).
Additionally,
Escherichia
coli,
Candida
albicans,
Pseudomonas
aeruginosa
exhibited
highest
susceptibility
binary
EOs.
Moreover,
alone
demonstrated
total
phosphomolybdenum
assay.
Furthermore,
molecular
docking
main
strong
interactions
binding
sites
selected
proteins,
confirming
antibacterial
properties.
research
contributes
valorization
natural
resources
opens
new
perspectives
for
exploitation
pharmaceutical
environmental
sectors.
Language: Английский
Phytochemical characterization and multifaceted bioactivity assessment of essential oil from Clinopodium nepeta subsp. ascendens : potential for the food and pharmaceutical sectors
CyTA - Journal of Food,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 20, 2024
This
study
delves
into
the
biological
characteristics
of
Clinopodium
nepeta
subsp.
ascendens
(CNEO)
essential
oil,
an
indigenous
subspecies
eastern
Morocco.
Distinguished
by
its
purple
or
pale
pinkish-white
flowers,
CNEO
was
subjected
to
thorough
phytochemical
analysis
via
gas
chromatography-mass
spectrometry
(GC-MS),
revealing
21
terpene
compounds,
notably
Dihydrocarvone
(22.70%),
Neoisomenthol
(43.59%),
and
Pulegone
(20.55%).
These
recognized
for
their
pharmacological
attributes,
were
further
investigated
potential
applications.
Notably,
exhibited
dose-dependent
anti-inflammatory
effects
attenuating
nitric
oxide
(NO)
prostaglandin
E2
(PGE2)
production.
Moreover,
it
demonstrated
promising
anticancer
activity
against
MDA-MB-468,
HepG2,
HCT-15
cancer
cell
lines,
rivaling
doxorubicin's
effectiveness.
findings
underscore
CNEO's
nutraceutical
potential,
particularly
in
food
science
industry,
suggesting
use
as
a
functional
additive
with
both
nutritional
health
benefits
Language: Английский
Algerian Prickly Pear Seed By-Products: Fatty Acids Composition, Antioxidant, Enzyme Inhibitory Activities towards Tyrosinase, Urease, α-Amylase, and Cholinesterase, along with the Ability to Protect from Thermal Protein Denaturation
Nassiba Chafaa,
No information about this author
Camélia Mosbah,
No information about this author
Latifa Khattabi
No information about this author
et al.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(9), P. 1145 - 1145
Published: Aug. 30, 2024
Prickly
pear
seed
is
a
source
of
the
most
expensive
oil
in
world,
which
rich
vitamins
and
polyunsaturated
fatty
acids.
Its
extraction
generates
large
quantity
press
cake.
These
two
by-products
need
to
be
valued.
The
current
study
aimed
assess
acid
composition
phytochemical
In
addition,
antioxidant
inhibition
thermal
protein
denaturation
effects
both
Algerian
were
evaluated
with
their
inhibitory
action
against
activities
urease,
tyrosinase,
α-amylase,
cholinesterase
enzymes.
GC
MS
analysis
result
revealed
richness
our
linoleic
(74%)
palmitic
(13%)
acids
methyl
esters,
respectively.
chemical
cake
was
characterized
by
high
value
dry
matter
(94.94
±
0.05%),
especially
carbohydrates
(85.13
0.94%).
results
activity
presented
IC
Language: Английский
Formulation of a Three-Component Essential Oil Mixture from Lavandula dentata, Rosmarinus officinalis, and Myrtus communis for Improved Antioxidant Activity
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(8), P. 1071 - 1071
Published: Aug. 15, 2024
The
optimization
of
existing
natural
antioxidants
that
are
highly
effective
is
crucial
for
advancements
in
medicine
and
the
food
industry.
Due
to
growing
concerns
regarding
safety
synthetic
antioxidants,
researchers
increasingly
focusing
on
sources,
particularly
essential
oils
(EOs).
Combining
EOs
might
enhance
antioxidant
activity
due
increased
chemical
diversity.
This
study
investigates,
first
time,
properties
from
Lavandula
dentata,
Rosmarinus
officinalis,
Myrtus
communis,
both
individually
combination,
using
augmented-simplex
design
methodology.
vitro
evaluation
was
performed
DPPH
ABTS
radical
scavenging
assays.
Chromatography
gas-mass
spectrometry
(CG-MS)
revealed
1,8-cineol
(37.27%)
pinocarveol
(12.67%)
primary
components
L.
dentata;
verbenone
(16.90%),
camphor
(15.00%),
camphene
(11.03%)
predominant
R.
officinalis;
while
cineol
(43.32%)
main
component
M.
communis.
showed
varying
activities
against
radicals,
with
assay
values
ranging
194.10
±
3.01
541.19
3.72
µg/mL
134.07
1.70
663.42
2.99
µg/mL.
These
were
enhanced
when
combined.
optimal
blend
DPPHIC50
consisted
20%
50%
30%
For
highest
activity,
best
combination
18%
43%
40%
results
highlight
potential
EO
combinations
as
new
formulations
use
cosmeceutical,
food,
pharmaceutical
sectors.
Language: Английский
Design, synthesis, biological evaluation, kinetic studies and molecular modeling of imidazo-isoxazole derivatives targeting both α-amylase and α-glucosidase inhibitors
Etab AlRashidi,
No information about this author
Siwar Ghannay,
No information about this author
Abuzar E. A. E. Albadri
No information about this author
et al.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(20), P. e38376 - e38376
Published: Sept. 24, 2024
Language: Английский
Investigating the antidiabetic properties of Apium graveolens extract and its inhibition of enzymes associated with hyperglycemia
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
290, P. 138873 - 138873
Published: Dec. 18, 2024
Language: Английский