Bacteriophages as Targeted Therapeutic Vehicles: Challenges and Opportunities DOI Creative Commons

Srividhya Venkataraman,

Mehdi Shahgolzari,

Afagh Yavari

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(5), P. 469 - 469

Published: April 29, 2025

Bacteriophages, with their distinctive ability to selectively target host bacteria, stand out as a compelling tool in the realm of drug and gene delivery. Their assembly from proteins nucleic acids, coupled modifiable biologically unique properties, enables them serve efficient safe delivery systems. Unlike conventional nanocarriers, which face limitations such non-specific targeting, cytotoxicity, reduced transfection efficiency vivo, engineered phages exhibit promising potential overcome these hurdles improve outcomes. This review highlights bacteriophage-based systems innovative for delivering therapeutic agents. It explores strategies engineering bacteriophage, categorizes principal types employed delivery, evaluates applications disease therapy. provides intriguing details use natural therapy diseases cancer, bacterial viral infections, veterinary diseases, neurological disorders, well phage display technology generating monoclonal antibodies against various human diseases. Additionally, CRISPR-Cas9 genetically is elucidated. Furthermore, it critical analysis challenges associated phage-based systems, offering insights overcoming obstacles. By showcasing advancements integration into nanotechnology, this study underscores revolutionize approaches inspire future innovations medicine.

Language: Английский

Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology DOI Creative Commons
Kai Jin, Yi Huang, Hailong Che

et al.

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

Using synthetic biology techniques, bacteria have been engineered to serve as microrobots for diagnosing diseases and delivering treatments. These can be used individually or in combination microbial consortia. The components within these consortia complement each other, enhancing diagnostic accuracy providing synergistic effects that improve treatment efficacy. application of therapies cancer, intestinal diseases, metabolic disorders underscores their significant potential. impact on the host's native microbiota is crucial, microbes modulate interact with environment, influencing outcomes overall health. Despite numerous advancements, challenges remain. include ensuring long-term survival safety bacteria, developing new chassis gene editing techniques non-model strains, minimising potential toxicity, understanding bacterial interactions host microbiota. This mini-review examines current state disease diagnosis treatment, highlighting challenges, future directions this promising field.

Language: Английский

Citations

3
Phage Therapy: A Targeted Approach to Overcoming Antibiotic Resistance DOI Creative Commons
David B. Olawade, Oluwaseun Fapohunda,

Eghosasere Egbon

et al.

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: unknown, P. 107088 - 107088

Published: Oct. 1, 2024

Language: Английский

Citations

9
Unravelling the Antibiotic Resistance: Molecular Insights and Combating Therapies DOI

Pandi Palanikumar,

N. Bharathi,

Karthikeyan Muthusamy

et al.

Applied Biochemistry and Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

Citations

0
Phage treatment of multidrug-resistant bacterial infections in humans, animals, and plants: The current status and future prospects DOI Creative Commons

Omor Faruk,

Zilhas Ahmed Jewel,

Sanjoy Bairagi

et al.

Infectious Medicine, Journal Year: 2025, Volume and Issue: 4(1), P. 100168 - 100168

Published: Feb. 6, 2025

Phages, including the viruses that lyse bacterial pathogens, offer unique therapeutic advantages, their capacity to antibiotic-resistant bacteria and disrupt biofilms without harming host microbiota. The lack of new effective antibiotics growing limitations existing have refocused attention on phage therapy as an option in complex clinical cases such burn wounds, cystic fibrosis, pneumonia. This review describes preclinical studies which has been both human veterinary medicine, agricultural context. In addition, critical challenges, narrow range bacteriophages, possibility resistance, regulatory constraints widespread use therapy, are addressed. Future directions include optimizing through strategies ranging from cocktails broadening genetic modification, using phages vaccines or biocontrol agents. future, if can be efficiently delivered, maintained a stable state, phage-antibiotic synergy achieved, will much needed treatment options. However, successful implementation within current standards practice also require considerable development infrastructure greater public acceptance. closing, this highlights promise backup substitute for antibiotics. It proposes role significant adjunct to, even replacement for, treating multidrug-resistant infections.

Language: Английский

Citations

0
Bacteriophages as Targeted Therapeutic Vehicles: Challenges and Opportunities DOI Creative Commons

Srividhya Venkataraman,

Mehdi Shahgolzari,

Afagh Yavari

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(5), P. 469 - 469

Published: April 29, 2025

Bacteriophages, with their distinctive ability to selectively target host bacteria, stand out as a compelling tool in the realm of drug and gene delivery. Their assembly from proteins nucleic acids, coupled modifiable biologically unique properties, enables them serve efficient safe delivery systems. Unlike conventional nanocarriers, which face limitations such non-specific targeting, cytotoxicity, reduced transfection efficiency vivo, engineered phages exhibit promising potential overcome these hurdles improve outcomes. This review highlights bacteriophage-based systems innovative for delivering therapeutic agents. It explores strategies engineering bacteriophage, categorizes principal types employed delivery, evaluates applications disease therapy. provides intriguing details use natural therapy diseases cancer, bacterial viral infections, veterinary diseases, neurological disorders, well phage display technology generating monoclonal antibodies against various human diseases. Additionally, CRISPR-Cas9 genetically is elucidated. Furthermore, it critical analysis challenges associated phage-based systems, offering insights overcoming obstacles. By showcasing advancements integration into nanotechnology, this study underscores revolutionize approaches inspire future innovations medicine.

Language: Английский

Citations

0