From LncRNA to metastasis: The MALAT1-EMT axis in cancer progression

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 154959 - 154959

Published: Nov. 19, 2023

Language: Английский

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Knockdown of integrin β1 inhibits proliferation and promotes apoptosis in bladder cancer cells

BioFactors, Journal Year: 2024, Volume and Issue: 51(1)

Published: Dec. 7, 2024

Abstract Bladder cancer (BC) is the most common urinary tract malignancy. Identifying biomarkers that predict prognosis and immune function in patients with BC can enhance our understanding of its pathogenesis provide valuable guidance for diagnosis treatment. Our findings indicate increased ITGB1 expression associated higher clinical grade stage, establishing as an independent prognostic risk factor BC. Enrichment analysis revealed was linked to extracellular matrix. The experimental results showed knockdown cell lines 5637 RT112 reduced their proliferation, migration, invasion. Furthermore, suppression promotes apoptosis cells by inhibiting PI3K‐AKT pathway. A model incorporating CES1, NTNG1, SETBP1, AIFM3 developed based on ITGB1, this accurately patient immunological status. In conclusion, study shows restrain migratory invasive capabilities accelerate apoptosis, role might be PI3K‐AKT, highlighting potential a diagnostic marker therapeutic target

Language: Английский

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CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(2), P. 277 - 287

Published: Jan. 26, 2024

The intricate molecular landscape of cancer pathogenesis continues to captivate researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the dynamic regulation biological functions. study investigates elusive link between circRNAs and Transforming Growth Factor-β (TGF-β) signalling pathway, exploring their collective influence on progression metastasis. Our comprehensive investigation begins by profiling circRNA expression patterns diverse types, revealing a repertoire intricately linked TGF-β pathway. Through integrated bioinformatics analyses functional experiments, we elucidate specific circRNA-mRNA interactions that modulate signalling, unveiling regulatory controls governing this crucial Furthermore, provide compelling evidence impact circRNA-mediated modulation key cellular processes, including epithelial-mesenchymal transition (EMT), migration, cell proliferation. In addition mechanistic roles, have shown promise diagnostic prognostic biomarkers, well potential targets for therapy. Their ability critical pathways, such axis, underscores significance biology clinical applications. interplay is dissected, uncovering novel circuits contribute complexity biology. This review unravels previously unexplored dimension carcinogenesis, emphasizing role shaping landscape.

Language: Английский

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Non-invasive diagnosis for urothelial carcinoma using a dual-target DNA methylation biomarker panel

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120164 - 120164

Published: Jan. 1, 2025

Language: Английский

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Cell-free Tumor DNA: a Promising Technology for Diagnosis, Surveillance and Therapeutic Decision in Urothelial Carcinoma of the Bladder

Current Oncology Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

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Immunotherapy for Bladder Cancer: Latest Advances and Ongoing Clinical Trials

Immunological Investigations, Journal Year: 2022, Volume and Issue: 51(8), P. 2226 - 2251

Published: Sept. 9, 2022

For nearly 50 years, immunotherapy has been used in patients with bladder cancer the form of Mycobacterium bovis Bacillus Calmette-Guerin (BCG), which is still first-line therapy for non-muscle invasive disease. However, remarkable results obtained checkpoint inhibitor drugs, including Pembrolizumab and Atezolizumab, have fueled quest to optimize these other forms both as well advanced cancer. In this review we summarize current state rapidly evolving field highlighting novel approaches ongoing trials exciting area research.

Language: Английский

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Fatty Acid Synthase Is the Key Regulator of Fatty Acid Metabolism and Is Related to Immunotherapy in Bladder Cancer

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: March 22, 2022

Fatty acid metabolism (FAM) genes are potentially useful for predicting prognosis and immunotherapy response in bladder cancer (BC). To examine this, we constructed a prognostic model identified key FAM BC. Using transcriptional expression profiles clinical data of BC patients from public datasets Changhai (CH) hospital, built validated risk-score based on 13 genes. Differential gene fatty synthase (FASN) as central to FASN was differentially expressed between normal tumor tissue, related survival. In the CH dataset, independently predicted muscle-invasive differential significantly immune-cell infiltration with low responded better immune checkpoint inhibitor (ICI) treatment. SREBF1 most significant transcription factor FASN. Competing endogenous RNA network analysis suggested that lncRNA AC107027.3 may upregulate by competitively binding miR-27A-3p, thereby regulating Dasatinib temsirolimus potential FASN-targeting drugs. Our efficiently is metabolism, indicator regulator ICI

Language: Английский

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Management of Metastatic Urothelial Carcinoma in Emerging Markets (EM): An Expert Opinion

Clinical Genitourinary Cancer, Journal Year: 2024, Volume and Issue: 22(2), P. 467 - 475

Published: Jan. 4, 2024

Urothelial carcinoma (UC) is the 10

Language: Английский

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The value of urinary exosomal microRNA‐21 in the early diagnosis and prognosis of bladder cancer

The Kaohsiung Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 40(7), P. 660 - 670

Published: May 27, 2024

Bladder cancer (BC) poses high morbidity and mortality, with urinary exosomal microRNA (miR)-21 showing potential value in its diagnosis prognosis, we probed specific role. We prospectively selected 116 BC patients healthy volunteers as the control groups, respectively. miR-146a-5p, miR-93-5p, miR-663b, miR-21, miR-4454 relative expression levels were assessed. The correlations between clinical indexes prognostic of diagnostic five candidate miRNAs, urine cytology, miRNA joint panel for miR-4454, cytology Ta-T1 T2-T4 stage analyzed. Urinary highly expressed patients. combined panel, had certain BC, co-diagnostic highest value. Collectively, miR-21 was closely related to Tumor-Node-Metastasis staging grading predictive poor providing an effective indicator occurrence, development, assessment BC.

Language: Английский

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Current advances in the application of nanomedicine in bladder cancer

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 157, P. 114062 - 114062

Published: Dec. 2, 2022

Bladder cancer is the most common malignant tumor of urinary system, however there are several shortcomings in current diagnostic and therapeutic measures. In terms diagnosis, tools currently available not sufficiently sensitive specific, imaging poor, leading to misdiagnosis missed diagnoses, which can delay treatment. treatment, treatment options include surgery, chemotherapy, immunotherapy, gene therapy, other emerging treatments, as well combination therapies. However, main reasons for poor efficacy side effects during lack specificity targeting, improper dose control drugs photosensitizers, damage normal cells while attacking cells, difficulty delivering siRNA cells. Nanomedicine an approach. Among many nanotechnologies applied medical field, nanocarrier-assisted drug delivery systems have attracted extensive research interest due their great translational value. Well-designed nanoparticles deliver agents or specific cell types within target organs through active targeting passive (enhanced permeability retention), allows imaging, cancer. This paper reviews advances application various nanocarriers advantages drawbacks, with a focus on use diagnosis bladder

Language: Английский

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