Taraxasterol enhanced bladder cancer cells radiosensitivity via inhibiting the COX-2/PGE2/JAK2/STAT3/MMP pathway

International Journal of Radiation Biology, Journal Year: 2024, Volume and Issue: 100(5), P. 791 - 801

Published: March 5, 2024

Purpose Radiotherapy with bladder preservation is highly acceptable among patients bearing cancer (BCa), but the occurrence of secondary tolerance (ARR) during treatment one important reasons for failure clinical radiotherapy. COX-2 has been frequently reported to be expressed and associated radio-resistance in various cancers. In this study, feasibility Taraxasterol (Tara) as a radiosensitizer was investigated, target effect Tara on its underlying mechanism were explored.

Language: Английский

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Prognostic significance and immune landscape of a cell cycle progression-related risk model in bladder cancer

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 12, 2024

Abstract Background A greater emphasis has been placed on the part of cell cycle progression (CCP) in cancer recent years. Nevertheless, precise connection between CCP-related genes and bladder (BCa) remained elusive. This study endeavors to establish validate a reliable risk model incorporating factors, aiming predict both prognosis immune landscape BCa. Methods Clinical information RNA sequencing data were collected from GEO TCGA databases. Univariate multivariate Cox regression analyses conducted construct associated with CCP. The performance was assessed using ROC Kaplan–Meier survival analyses. Functional enrichment analysis employed investigate potential cellular functions signaling pathways. characterized CIBERSORT algorithms. Integration various clinical variables led development nomogram. Results To build model, three (RAD54B, KPNA2, TPM1) carefully chosen. confirm that our good performance. About immunological infiltration, high-risk group showed decreased levels regulatory T cells dendritic coupled increased activated CD4 + memory cells, M2 macrophages, neutrophils. Furthermore, nomogram impressive predictive power for OS at 1, 3, 5 Conclusion provides new insights into association BCa, as well its impact landscape.

Language: Английский

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Advancements in nanomedicine: Precision delivery strategies for male pelvic malignancies – Spotlight on prostate and colorectal cancer

Experimental and Molecular Pathology, Journal Year: 2024, Volume and Issue: 137, P. 104904 - 104904

Published: May 25, 2024

Pelvic malignancies consistently pose significant global health challenges, adversely affecting the well-being of male population. It is anticipated that clinicians will continue to confront these cancers in their practice. Nanomedicine offers promising strategies revolutionize treatment pelvic by providing precise delivery methods aim improve efficacy therapeutic outcomes while minimizing side effects. Nanoparticles are designed encapsulate agents and selectively target cancer cells. They can also be loaded with theragnostic agents, enabling multifunctional capabilities.

Language: Английский

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Data-mining-based biomarker evaluation and experimental validation of SHTN1 for bladder cancer

Cancer Genetics, Journal Year: 2024, Volume and Issue: 288-289, P. 43 - 53

Published: Sept. 7, 2024

Language: Английский

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LncRNAs in necroptosis: Deciphering their role in cancer pathogenesis and therapy

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155252 - 155252

Published: March 5, 2024

Language: Английский

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