Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 311 - 349
Published: Jan. 1, 2024
Language: Английский
BMEMat, Journal Year: 2023, Volume and Issue: 1(3)
Published: June 30, 2023
Abstract Diabetic foot ulcers (DFU) are a common and often debilitating complication of diabetes that can result in lower limb amputations if left untreated. Hydrogel dressings three‐dimensional networks hydrophilic polymers absorb retain large amounts water, have been shown to possess excellent biocompatibility, low toxicity, fluid handling properties. In addition, hydrogels create moist wound environment promotes healing by supporting cell proliferation, migration, angiogenesis. Hydrogels, therefore, emerged as promising for promoting DFU healing. this review, we attempt chart the landscape emerging field hydrogel dressing treatment. We will explicitly review assorted preparation methods well detailed discussion various types deployed study. also crystallize key findings, identify remaining challenges, present an outlook on future development enticing field.
Language: Английский
Citations
67
Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 713 - 713
Published: March 14, 2025
Background/Objectives: Diabetes mellitus is characterized by a dysregulated glucose metabolism, necessitating frequent and often invasive monitoring techniques for its effective management. Saliva, non-invasive readily accessible biofluid, has been proposed as potential alternative glycemic due to biochemical correlation with blood levels. This scoping review aims evaluate the evidence regarding use of salivary biomarker track changes in diabetic populations. Methods: study adhered Joanna Briggs Institute guidelines PRISMA Extension Scoping Reviews. A literature search was performed across PubMed, Scopus, Web Science databases, supplemented manual searches. Results: total fifty-seven studies were included, representing populations affected type 1 diabetes (T1D), 2 (T2D), gestational (GD). The findings indicated consistent positive correlations between levels most studies, although there significant variations sensitivity, specificity, methodological approaches. Salivary showed promise complementary monitoring, particularly nature. Conclusions: Challenges such variability composition, absence standardized collection protocols, limited availability portable devices noted. highlights saliva an adjunct sample management while stressing need further research bridge existing gaps.
Language: Английский
Citations
2
Analytical Methods, Journal Year: 2023, Volume and Issue: 15(35), P. 4377 - 4404
Published: Jan. 1, 2023
The versatile uses of paper-based colorimetric sensors in POCT, include infectious disease diagnosis, chronic management, cancer diagnosis and monitoring, pregnancy fertility testing.
Language: Английский
Citations
28
World Journal of Advanced Research and Reviews, Journal Year: 2024, Volume and Issue: 21(1), P. 2740 - 2752
Published: Jan. 30, 2024
As healthcare systems strive to meet the evolving demands of an ever-changing landscape, biotechnology emerges as a pivotal force driving transformative advancements. This comprehensive review explores multifaceted role in healthcare, examining global trends that underscore its profound impact on diagnostics, treatment modalities, and overall landscape delivery. The study begins by elucidating fundamental principles diverse applications healthcare. From genomics personalized medicine, biotechnological innovations are reshaping understanding diseases, enabling tailored interventions based individual genetic profiles. delves into burgeoning field precision where tools empower clinicians deliver targeted therapies, optimize outcomes, minimize adverse effects. integration platforms including advanced imaging techniques liquid biopsies, is transforming early detection monitoring ushering era proactive Moreover, characterized collaborative research initiatives cross-disciplinary partnerships. interconnectedness with artificial intelligence data analytics explored, highlighting synergistic potential unlocking intricate patterns within vast datasets inform more precise effective strategies. accelerates development novel therapeutics, gene cell addresses ethical considerations, regulatory frameworks, accessibility challenges. It critically analyzes disparities adoption advancements across systems, emphasizing need for equitable access ensure benefits reach populations worldwide. In conclusion, elucidates extends beyond scientific breakthroughs encompass paradigm shift. By continents, it underscores power fostering new precision, innovation, unwavering commitment improving patient outcomes scale.
Language: Английский
Citations
9
Life, Journal Year: 2023, Volume and Issue: 13(9), P. 1831 - 1831
Published: Aug. 29, 2023
Diabetes poses a significant global health challenge, necessitating innovative therapeutic strategies. Natural products and their derivatives have emerged as promising candidates for diabetes management due to diverse compositions pharmacological effects. Algae, in particular, garnered attention potential source of bioactive compounds with anti-diabetic properties. This review offers comprehensive overview algae-derived natural management, highlighting recent developments future prospects. It underscores the pivotal role care delves into diversity algae, constituents, underlying mechanisms efficacy. Noteworthy algal substantial are briefly elucidated, along specific contributions addressing distinct aspects diabetes. The challenges limitations inherent utilizing algae interventions examined, accompanied by strategic recommendations optimizing effectiveness. By these considerations, this aims chart course research refining algae-based approaches. Leveraging multifaceted activities chemical components holds promise pursuit novel antidiabetic treatments. Through continued fine-tuning interventions, burden could be mitigated, ultimately leading enhanced patient outcomes.
Language: Английский
Citations
18
Molecules, Journal Year: 2024, Volume and Issue: 29(13), P. 3156 - 3156
Published: July 2, 2024
Electrochemical biosensors have emerged as powerful tools for the ultrasensitive detection of lung cancer biomarkers like carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), and alpha fetoprotein (AFP). This review comprehensively discusses progress potential nanocomposite-based electrochemical early diagnosis prognosis. By integrating nanomaterials graphene, metal nanoparticles, conducting polymers, these sensors achieved clinically relevant limits in fg/mL to pg/mL range. We highlight key role nanomaterial functionalization enhancing sensitivity, specificity, antifouling properties. also examines challenges related reproducibility clinical translation, emphasizing need standardization fabrication protocols robust validation studies. With rapid growth understanding innovations sensor design, nanocomposite hold immense point-of-care screening personalized therapy guidance. Realizing this goal will require strategic collaboration among material scientists, engineers, clinicians address technical practical hurdles. Overall, work provides valuable insight developing next-generation smart diagnostic devices combat high mortality cancer.
Language: Английский
Citations
6
Hybrid Advances, Journal Year: 2023, Volume and Issue: 3, P. 100052 - 100052
Published: June 9, 2023
Diabetes, a chronic, metabolic disease characterized by elevated levels of blood glucose, over time leads to serious damage the vessels, nerves, eyes, kidneys, and heart. Diabetes affects 422 million people globally, with majority residing in low- middle-income nations, approximately 1.5 deaths are directly attributed diabetes annually. Thus, detecting early is crucial prevent, monitor, or postpone advancement its associated complications. However, current glucose tests for diabetic patients have significant drawback that these methods require frequent intrusive sampling. Promisingly, salivary analysis has emerged as non-invasive convenient alternative monitoring approach diabetics. In this review, we attempt chart landscape emerging field analysis. It not our intention wholly review all related work, but rather an assorted selection seminar reports exemplify development trajectory burgeoning measurement (SGM). The fundamental advantageous nature SGM novel method diagnostic fields will be thematically thoroughly discussed. To inspire next-stage clinical transitional fruitful field, then explicate challenges remain addressed, present future directions
Language: Английский
Citations
16
Materials, Journal Year: 2023, Volume and Issue: 16(18), P. 6293 - 6293
Published: Sept. 20, 2023
The current review aims to provide an overview of the most recent research in last 10 years on potentials graphene dental surgery field, focusing potential oxide (GO) applied implant surfaces and prosthetic abutment surfaces, as well membranes scaffolds used Guided Bone Regeneration (GBR) procedures. “Graphene oxide” “dental surgery” “dentistry” were search terms utilized databases Scopus, Web Science, Pubmed, with Boolean operator “AND” “OR”. Reviewers worked pairs select studies based specific inclusion exclusion criteria. They included animal studies, clinical or case reports, vitro vivo studies. However, they excluded systematic reviews, narrative meta-analyses. Results: Of these 293 19 publications this review. field graphene-based engineered nanomaterials dentistry is expanding. Aside from its superior mechanical properties, electrical conductivity, thermal stability, derivatives may be functionalized a variety bioactive compounds, allowing them introduced into improved upon various regenerative dentistry. This presents state-of-the-art applications. Even if further investigations are still needed, GO coating could improve results examined fields. Better osseointegration, increased antibacterial cytocompatible qualities, can benefit GO-coated surgery. On bacterially contaminated CO optimum prospects for soft tissue sealing occur. GBR proves safe stable material, improving both bone regeneration when using GO-enhanced graft materials biocompatibility properties GO-incorporated membranes.
Language: Английский
Citations
13
Analytical Methods, Journal Year: 2023, Volume and Issue: 15(43), P. 5855 - 5866
Published: Jan. 1, 2023
Portable hydrogel-based wearable patch sensors were facilely prepared for colorimetric, real-time, rapid sweat analysis.
Language: Английский
Citations
11
Viruses, Journal Year: 2023, Volume and Issue: 15(12), P. 2395 - 2395
Published: Dec. 8, 2023
The hepatitis B virus (HBV) continues to cause substantial health and economic burdens, its target of elimination may not be reached in 2030 without further efforts diagnostics, non-pharmaceutical prevention measures, vaccination, treatment. Current therapeutic options chronic HBV, based on interferons and/or nucleos(t)ide analogs, suppress the replication but do eliminate pathogen suffer from several constraints. This paper reviews progress biotechnological approaches functional definitive HBV treatments, including gene-editing tools, i.e., zinc-finger proteins, transcription activator-like effector nucleases, CRISPR/Cas9, as well therapeutics RNA interference. advantages challenges these are also discussed. Although safety efficacy tools therapies yet demonstrated, they show promise for revitalization a much-needed advance field offer viral eradication. Particular hopes related CRISPR/Cas9; however, employing this system enter clinical testing phases. In contrast, number candidates interference, intending confer cure, have already been introduced human studies. However, larger longer trials required assess their safety. Considering that is always superior treatment, it essential pursue global vaccination.
Language: Английский
Citations
11