Role of Machine Learning Assisted Biosensors in Point-of-Care-Testing For Clinical Decisions

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(9), P. 4495 - 4519

Published: Aug. 15, 2024

Point-of-Care-Testing (PoCT) has emerged as an essential component of modern healthcare, providing rapid, low-cost, and simple diagnostic options. The integration Machine Learning (ML) into biosensors ushered in a new era innovation the field PoCT. This article investigates numerous uses transformational possibilities ML improving for algorithms, which are capable processing interpreting complicated biological data, have transformed accuracy, sensitivity, speed procedures variety healthcare contexts. review explores multifaceted applications models, including classification regression, displaying how they contribute to capabilities biosensors. roles ML-assisted electrochemical sensors, lab-on-a-chip electrochemiluminescence/chemiluminescence colorimetric wearable sensors diagnosis explained detail. Given increasingly important role PoCT, this study serves valuable reference researchers, clinicians, policymakers interested understanding emerging landscape point-of-care diagnostics.

Language: Английский

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A comprehensive review on enzyme-based biosensors: Advanced analysis and emerging applications in nanomaterial-enzyme linkage

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130817 - 130817

Published: March 11, 2024

Language: Английский

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Exploring Innovative Approaches for the Analysis of Micro- and Nanoplastics: Breakthroughs in (Bio)Sensing Techniques

Biosensors, Journal Year: 2025, Volume and Issue: 15(1), P. 44 - 44

Published: Jan. 13, 2025

Plastic pollution, particularly from microplastics (MPs) and nanoplastics (NPs), has become a critical environmental health concern due to their widespread distribution, persistence, potential toxicity. MPs NPs originate primary sources, such as cosmetic microspheres or synthetic fibers, secondary fragmentation of larger plastics through degradation. These particles, typically less than 5 mm, are found globally, deep seabeds human tissues, known adsorb release harmful pollutants, exacerbating ecological risks. Effective detection quantification essential for understanding mitigating impacts. Current analytical methods include physical chemical techniques. Physical methods, optical electron microscopy, provide morphological details but often lack specificity time-intensive. Chemical analyses, Fourier transform infrared (FTIR) Raman spectroscopy, offer molecular face challenges with smaller particle sizes complex matrices. Thermal including pyrolysis gas chromatography–mass spectrometry (Py-GC-MS), compositional insights destructive limited in analysis. Emerging (bio)sensing technologies show promise addressing these challenges. Electrochemical biosensors cost-effective, portable, sensitive platforms, leveraging principles voltammetry impedance detect adsorbed pollutants. Plasmonic techniques, surface plasmon resonance (SPR) surface-enhanced spectroscopy (SERS), high sensitivity nanostructure-enhanced detection. Fluorescent utilizing microbial enzymatic elements enable the real-time monitoring plastic degradation products, terephthalic acid polyethylene terephthalate (PET). Advancements innovative approaches pave way more accurate, scalable, environmentally compatible solutions, contributing improved remediation strategies. This review highlights advanced section on prospects that address could lead significant advancements monitoring, highlighting necessity testing new sensing developments under real conditions (composition/matrix samples), which overlooked, well study peptides novel recognition element microplastic sensing.

Language: Английский

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Electrochemical biosensors for point-of-care testing

Bio-Design and Manufacturing, Journal Year: 2024, Volume and Issue: 7(4), P. 548 - 565

Published: July 1, 2024

即时检验（POCT）是一种在患者身边进行疾病诊断和监测的做法，与仅在医学实验室或其他临床环境中进行的传统治疗不同。由于缺乏能够促进有效医疗测试的便携式医疗设备，POCT在最近过去较少见。然而这一领域近期呈现出增长态势，得益于诊断技术的进步、设备的小型化，以及可穿戴电子设备的快速发展。在这些发展中，电化学传感器因其高灵敏度、紧凑的尺寸并且经济实惠而在POCT领域引起了兴趣。它们被用于从疾病诊断到健康状况监测的各种应用。在本文中，我们探讨了电化学传感器的最新进展、制造它们的方法以及可以使用的各种传感机制。此外，我们还探究了如何将酶、抗体和核酸适配体等特定生物识别元素固定于电极表面，以及这些传感器在现实世界即时检验中的应用方式。

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Contact lens as an emerging platform for non-invasive bio-sensing: A review

Sensors and Actuators A Physical, Journal Year: 2024, Volume and Issue: 376, P. 115617 - 115617

Published: July 2, 2024

Contact lenses are emerging as a promising platform for non-invasive biosensing of various biomarkers in tear fluid. This review covers recent advances developing contact lens-based biosensors detecting glucose, lactate, intraocular pressure, matrix metalloproteinases, and cancer biomarkers. Photonic crystal-based colorimetric sensors exploiting the diffraction visible light have shown great potential continuous monitoring glucose levels. Electrochemical enzymatic integrated into also been explored lactate glucose. Novel sensing approaches based on microfluidics, antiopal photonic structures, cantilevers, surface-enhanced Raman spectroscopy substrates enabled measurement inflammatory like MMP-9, exosomes offer unique advantages being non-invasive, providing direct sample interface, enabling monitoring, integrating multiple modalities. However, challenges related to enzyme stability, calibration, manufacturing scalability, sterilization, regulatory approval need be addressed before widespread clinical implementation. Overall, this multidisciplinary field combining with advanced technologies holds immense transforming healthcare through predictive, preventive, personalized ocular systemic conditions.

Language: Английский

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Biogenic carbon nanostructured materials for detection of cancer and medical applications: A mini review

Hybrid Advances, Journal Year: 2024, Volume and Issue: 5, P. 100166 - 100166

Published: March 1, 2024

In this new era, the cutting-edge progress of numerous technologies for modern and better lifestyles as well a wide range aquatic global habitats by increasing anthropogenic activities is directly responsible contaminated potable water edible things, which are hazardous to living entities. recent decades, there has been lot interest in several research groups biomass renewable energy source or biogenic carbon-based devices medical applications. Biomass such wheat straw ash (WSA), rice husk (RHA), sugarcane bagasse (SBA), coconut peal (CPA), sunflower (SHA), peanut peel (PPA), walnut (WPA) waste coffee beans contain an enormous quantity carbon, ashes can be utilized generating high-quality nanomaterials graphene (Gr), oxide (GO) CNTs that excellent purity from combustion by-products total process practically environmentally beneficial terms CO2 emissions warming. The unique properties nanostructures play vital role enhancing performance detection tools cancer its therapy overcome diseases. Thus, significance carbon allotropes underlined, with particular emphasis on nanostructured healthcare products high-surface-area adsorbents, mechanically stable devices, tailored instinctive micro-based assist avoiding health problem. This review summarizes affordable, modern, sophisticated applications using high-valued materials, particularly production CNTs, used make biomarkers, biosensors, bio-imaging, gene drug delivery systems, initial stage treatment.

Language: Английский

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Recent advances in nicotine electrochemical biosensors: A review

Case Studies in Chemical and Environmental Engineering, Journal Year: 2024, Volume and Issue: 9, P. 100753 - 100753

Published: May 16, 2024

The chemical compound nicotine, specifically 3-(1-methyl-2-pyrrolidinyl) pyridine, is a notable xenobiotic under investigation in the realm of electrochemical biosensors. This article emphasizes nature this substance and its impact on human body. Different species with pharmacological, therapeutic, industrial, food-related, environmental origins can now be detected using sensors. Nicotine, an addictive tobacco products electronic cigarettes (e-cigs), recognized for increasing risk cardiovascular respiratory disorders. Careful real-time monitoring nicotine exposure critical alleviating potential health impacts not just smokers but also those exposed to second-hand third-hand smoke. Monitoring requires suitable sensing material detect selectively testing free-living conditions standard environment. A biosensor consists sensitive biological system detector appropriate transducers obtaining output signals. applications these devices include screening, detection contaminants, farming, routine medical examinations. Critical factors widespread commercialization will product's selectivity, sensitivity, stability, lower production costs. Scientists have been working developing nano high degree sensitivity selectivity recognition biomarkers immune responses cancer. An analysis various parameters, including Limit Detection (LOD) concentration within pH range (7-7.4), has conducted. objective enhance expand linear range, optimize optical electrical properties. delves into optimization sensors biosensors from perspective, highlighting positive negative effects as well metabolic pathways study categorizes evaluates latest based their generation (electron transfer between multilayers) methods (modification types or direct electrodes). strengths weaknesses each are scrutinized over past 15 years, focus solely

Language: Английский

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Review on emerging applications of nanobiosensor in food safety

Journal of Food Science, Journal Year: 2024, Volume and Issue: 89(7), P. 3950 - 3972

Published: June 7, 2024

Nanosensors have become an indispensable tool in the food sector due to their specificity and sensitivity. The biosensor consists of a transducer coupled with biorecognition component transform biological signal into digital signal. Nanobiosensors been widely used for sensing toxic chemicals such as pesticide residues pathogenic microbes owing accurate sensitivity affordable manner, which gives more hope industry on applications. It employs nanocarriers bind impurities pollutants, well food-borne microorganisms resulting toxins, mycotoxins. This modern technology ensures safety processing industries. Nowadays, nanoparticle-immobilized sensors act spot indicators improve smart packing technology. Certain types nanobiosensors are deployed monitor product manufacture till packaging check freshness spoilage identification. They mainly using enzyme catalysts, highly sensitive extreme environmental conditions. As result, there is greater evaluation requirement nanosensor adopt any temperature, pH, or other difficult parameters. Its stability, while contact substrates, another criterion that needs be regularized. Within this framework, review delves latest developments obstacles encountered during use across different

Language: Английский

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Advancing foodborne pathogen detection: a review of traditional and innovative optical and electrochemical biosensing approaches

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(2)

Published: Jan. 22, 2025

Language: Английский

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2D Heterostructure-Based Sweat and Heat Sensors

ACS Applied Electronic Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

2D heterostructures, made by stacking ultrathin materials, are becoming key for advanced sweat and heat sensors in noninvasive health monitoring. These meticulously designed structures leverage the synergistic properties of individual materials. Integration graphene transition metal dichalcogenides (TMD) enables highly selective that monitor electrolytes, offering insights into hydration electrolyte imbalances. In this regard, there is considerable versatility sensor types, which covered throughout review. Some examples include electrochemical sensors, enzyme-free, Joule-heating, flexible stretchable, molecularly imprinted polymer (MIP), multimodal, among others. On other hand, also a plethora can be developed through use heterostructures. A widely explored material hexagonal boron nitride (h-BN), displays exceptional thermal conductivity. By combining h-BN with researchers engineer heterostructures accurately flux, providing core body temperature data thermoregulation purposes. However, challenges such as long-term stability biocompatible integration remain. Yet, sensing great terms types available, based on thermoresistivity, expansion, thermally induced phase change, optical heat, calorimetric, Even though current to improvement their biocompatibility, robusticity, optimization manufacturing large-scale applications, future heterostructure-based bright. addressing these continuously innovating, revolutionize personalized monitoring, empower individuals track metrics real time, pave way wearable devices, ultimately improving wellness management athletic performance. This review explores emerging applications heterostructure nanomaterials development The ability conveniently noninvasively assess biomarkers holds significant promise technologies. discusses state-of-the-art material-based including recent advancements materials design, fabrication, analysis. Challenges related production, stability, platforms discussed. Finally, outlines research directions, highlighting need developing cost-effective fabrication methods, integrating analytics real-time monitoring medicine.

Language: Английский

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