PiD - Psychotherapie im Dialog, Journal Year: 2023, Volume and Issue: 24(03), P. 51 - 55
Published: Aug. 28, 2023
Das Post-COVID-19-Syndrom (PCS) kann vielfältige Ursachen haben und wird in den meisten Fällen sicher am besten polykausal erklärbar sein. Damit verspricht eine multimodale Diagnostik Behandlung ehesten Erfolg. Der Beitrag skizziert, welche immunologischen Faktoren zu PCS beitragen können Zusammenhänge zwischen neuroimmunologischen psychischen bestehen.
Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(7), P. 7001 - 7031
Published: July 4, 2024
Vitamin K (VK) is an essential micronutrient impacting many systems in the body. This lipid-soluble vitamin found various plant and animal products absorbed via lymphatic system. biomolecule's importance to human health includes but not limited its promotion of brain, cardiovascular, bone, immune functions. These biological properties are also necessary for maintaining domesticated health. The synergistic impact both VK D (VD) maximizes these benefits, specifically circulatory skeletal systems. manuscript reviews VK's properties, molecular structures, nutrikinetics, mechanisms action, daily requirements, safety supplemental form, biomarkers used detection, impacts on organs. purpose synthesizing this information evaluate potential uses treatment or prevention diseases.
Language: Английский
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4
The Yale Journal of Biology and Medicine, Journal Year: 2024, Volume and Issue: 97(4), P. 447 - 462
Published: Dec. 19, 2024
Post-Acute Sequelae of SARS-CoV-2 infection (PASC), commonly known as Long COVID, represents a significant and complex health challenge with wide range symptoms affecting multiple organ systems. This review examines the emerging evidence suggesting critical role gut gut-brain axis in pathophysiology COVID. It explores how changes microbiome, disruption barrier integrity, persistence antigens within gastrointestinal tract may contribute to prolonged varied seen including chronic inflammation neuropsychiatric disturbances. The also summarizes key insights gained about highlighting its multifactorial nature, which involves immune dysregulation, microvascular damage, autonomic nervous system dysfunction, playing central these processes. While progress has been made understanding mechanisms, current remains inconclusive. challenges establishing causality, standardizing research methodologies, addressing individual variations microbiome are discussed, emphasizing need for further longitudinal studies more comprehensive approaches enhance our interactions. underscores importance personalized developing effective diagnostic therapeutic strategies while acknowledging gaps understanding. Future should aim unravel interplay between ultimately improving outcomes those affected by this condition.
Language: Английский
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Published: March 5, 2024
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Published: March 5, 2024
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Published: March 5, 2024
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Published: March 5, 2024
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Published: March 5, 2024
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Published: March 5, 2024
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Published: March 5, 2024
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Medical Journal of the Islamic Republic of Iran, Journal Year: 2023, Volume and Issue: unknown
Published: Oct. 20, 2023
In human and animal studies, ankylosing spondylitis (AS) has been increasingly linked to changes in the microbial inhabitants body (microbiome). These studies have primarily now concentrated on communities that live gastrointestinal tract. However, evidence suggests various molecular techniques can be used detect DNA blood circulation. This might an unknown reservoir of biomarkers with potential track alterations microbiomes remote locations, such as gut. To this end, we compared presence identity samples taken from patients healthy control subjects by amplifying sequencing bacterial 16S rRNA variable region four.The study's design is a case study based Ankylosing (n = 10) was investigated gene. Blood concentrations cytokines TNF alpha, IL-17A, IL-23 were determined Human Magnetic Luminex Screening, data analysed using Unpaired T-test.Using PCR amplification, 8 10 AS (80%) had their blood. At phylum level, Proteobacteria (Control 48.5%, 52%), Firmicutes 27.8%, 26.1%), Actinobacteria 15.4%, 10.7%), Bacteroidetes 6.5%, 10%) dominated microbiome. A two-tailed Mann-Whitney test found Spondylitis associated significantly elevated Bacteroides (P < 0.05), Prevotella 0.001), Micrococcus 0.01), reduced levels Corynebacterium 1 Gemella Alloprevotella controls. Additionally, it shown genus highly positively correlated higher TNF-alpha 0.05; r 0.8) patients' blood.This article reveals microbiome exists individuals identifies particular taxa modulated disease. blood-derived signatures indicate field needs more research may helpful disease biomarkers.
Language: Английский
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1