RETRACTED: Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

International Journal of Antimicrobial Agents, Journal Year: 2020, Volume and Issue: 56(1), P. 105949 - 105949

Published: March 20, 2020

Language: Английский

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Angiotensin‐converting enzyme 2 (ACE2), SARS‐CoV‐2 and the pathophysiology of coronavirus disease 2019 (COVID‐19)

The Journal of Pathology, Journal Year: 2020, Volume and Issue: 251(3), P. 228 - 248

Published: May 17, 2020

Angiotensin-converting enzyme 2 (ACE2) has been established as the functional host receptor for severe acute respiratory syndrome coronavirus (SARS-CoV-2), virus responsible current devastating worldwide pandemic of disease 2019 (COVID-19). ACE2 is abundantly expressed in a variety cells residing many different human organs. In physiology, pivotal counter-regulatory to ACE by breakdown angiotensin II, central player renin-angiotensin-aldosterone system (RAAS) and main substrate ACE2. Many factors have associated with both altered expression COVID-19 severity progression, including age, sex, ethnicity, medication, several co-morbidities, such cardiovascular metabolic syndrome. Although widely distributed various tissues its determinants well recognised, ACE2-expressing organs do not equally participate pathophysiology, implying that other mechanisms are involved orchestrating cellular infection resulting tissue damage. Reports pathologic findings specimens patients rapidly emerging confirm role activity pathogenesis. Identifying changes caused SARS-CoV-2 crucially important it major implications understanding pathophysiology development evidence-based treatment strategies. Currently, interventional strategies being explored ongoing clinical trials, encompassing drug classes strategies, antiviral drugs, biological response modifiers, RAAS inhibitors. Ultimately, prevention key combat appropriate measures taken accordingly, effective vaccines. this review, we describe influencing relation severity. addition, discuss relevant pathological from infection. Finally, highlight selection potential modalities COVID-19. © 2020 The Authors. Journal Pathology published John Wiley & Sons Ltd on behalf Pathological Society Great Britain Ireland.

Language: Английский

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COVID-19: Transmission, prevention, and potential therapeutic opportunities

Clinica Chimica Acta, Journal Year: 2020, Volume and Issue: 508, P. 254 - 266

Published: May 29, 2020

Language: Английский

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Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: March 20, 2020

Abstract Background Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, reported in Chinese COV-19 patients. We evaluate the role of respiratory viral loads. Patients methods were included a single arm protocol receive 600mg daily their load nasal swabs was tested daily. Depending clinical presentation, azithromycin added treatment. Untreated patients from another center cases refusing as negative controls. Presence absence virus at Day6-post inclusion considered end point. Results Twenty treated this study showed significant reduction carriage D6-post compared controls, much lower average carrying duration than untreated literature. Azithromycin significantly more for elimination. Conclusion Hydroxychloroquine is associated with reduction/disappearance COVID-19 its effect reinforced by azithromycin.

Language: Английский

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The Food Systems in the Era of the Coronavirus (COVID-19) Pandemic Crisis

Foods, Journal Year: 2020, Volume and Issue: 9(4), P. 523 - 523

Published: April 22, 2020

The World Health Organization (WHO) declared the outbreak of coronavirus disease (COVID-19, broadly referred to as “coronavirus”) a global pandemic, while thousands infections and deaths are reported daily. current article explores food systems in era COVID-19 pandemic crisis. It provides insights about properties bioactive ingredients foods herbs for support human immune system against before discussing possibility transmission through chain. also highlights security issues arising from fact that one-third world’s population is on lockdown. Finally, it underlines importance sustainability chain order avoid or reduce frequency relevant health crises future.

Language: Английский

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Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards

European Journal of Clinical Microbiology & Infectious Diseases, Journal Year: 2020, Volume and Issue: 39(6), P. 1059 - 1061

Published: April 27, 2020

Abstract In a preliminary clinical study, we observed that the combination of hydroxychloroquine and azithromycin was effective against SARS-CoV-2 by shortening duration viral load in Covid-19 patients. It is paramount importance to define when treated patient can be considered as no longer contagious. Correlation between successful isolation virus cell culture Ct value quantitative RT-PCR targeting E gene suggests patients with above 33–34 using our system are not contagious thus discharged from hospital care or strict confinement for non-hospitalized

Language: Английский

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COVID-19: A promising cure for the global panic

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 725, P. 138277 - 138277

Published: April 4, 2020

Language: Английский

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Covid-19 and autoimmunity

Autoimmunity Reviews, Journal Year: 2020, Volume and Issue: 19(8), P. 102597 - 102597

Published: June 11, 2020

Language: Английский

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COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation

Nutrients, Journal Year: 2020, Volume and Issue: 12(5), P. 1466 - 1466

Published: May 19, 2020

The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has engulfed the world, affecting more than 180 countries. As a result, there been considerable economic distress globally and significant loss of life. Sadly, vulnerable immunocompromised in our societies seem to be susceptible COVID-19 complications. Global public health bodies governments have ignited strategies issued advisories on various handwashing hygiene guidelines, social distancing strategies, and, most extreme cases, some countries adopted “stay place” or lockdown protocols prevent spread. Notably, are several risk factors for infection. These include presence poor nutritional status pre-existing noncommunicable diseases (NCDs) such as diabetes mellitus, chronic lung diseases, cardiovascular (CVD), obesity, other that render patient immunocompromised. characterized systemic inflammation, which may common feature these NCDs, outcomes against COVID-19. In this review, we discuss anti-inflammatory therapies currently under investigation intended dampen cytokine storm infections. Furthermore, role diet lifestyle is considered, it known affect infections play This review speculates importance nutrition mitigation strategy support immune function amid pandemic, identifying food groups key nutrients

Language: Английский

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Contact with blue-green spaces during the COVID-19 pandemic lockdown beneficial for mental health

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 756, P. 143984 - 143984

Published: Nov. 26, 2020

Language: Английский

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