Aminoglycosides for the Treatment of Severe Infection Due to Resistant Gram-Negative Pathogens

Antibiotics, Journal Year: 2023, Volume and Issue: 12(5), P. 860 - 860

Published: May 6, 2023

Aminoglycosides are a family of rapidly bactericidal antibiotics that often remain active against resistant Gram-negative bacterial infections. Over the past decade, their use in critically ill patients has been refined; however, due to renal and cochleovestibular toxicity, indications treatment sepsis septic shock have gradually reduced. This article reviews spectrum activity, mode action, methods for optimizing efficacy aminoglycosides. We discuss current aminoglycosides, with an emphasis on multidrug-resistant bacteria, such as extended-spectrum β-lactamase-producing Enterobacterales, carbapenemase-producing Pseudomonas aeruginosa, carbapenem-resistant Acinetobacter baumannii. Additionally, we review evidence nebulized

Language: Английский

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ESKAPE in China: epidemiology and characteristics of antibiotic resistance

Emerging Microbes & Infections, Journal Year: 2024, Volume and Issue: 13(1)

Published: Feb. 15, 2024

The escalation of antibiotic resistance and the diminishing antimicrobial pipeline have emerged as significant threats to public health. ESKAPE pathogens - Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp. were initially identified critical multidrug-resistant bacteria, demanding urgently effective therapies. Despite introduction various new antibiotics adjuvants, such innovative β-lactamase inhibitors, these organisms continue pose substantial therapeutic challenges. People's Republic China, a country facing severe bacterial situation, has undergone series changes findings in recent years terms prevalence, transmission characteristics mechanisms resistant bacteria. increasing levels population mobility not only shaped unique prevalence within China but also indirectly reflected global patterns antibiotic-resistant dissemination. What's more, vast nation, exhibits variations bacteria across different provinces regions. In this review, we examine current epidemiology important group pathogens, delving into relevant recently introduced that impact their clinical utility China.

Language: Английский

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Resistance mechanisms of tigecycline in Acinetobacter baumannii

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: May 9, 2023

Acinetobacter baumannii is widely distributed in nature and hospital settings a common pathogen causing various infectious diseases. Currently, the drug resistance rate of A. has been persistently high, showing worryingly high to antibiotics commonly used clinical practice, which greatly limits antibiotic treatment options. Tigecycline polymyxins show rapid effective bactericidal activity against CRAB, they are both considered be last line defense multidrug resistant baumannii. This review focuses with interest on mechanisms tigecycline With explosive increase incidence tigecycline-resistant baumannii, controlling treating such events global challenge. Accordingly, there need systematically investigate mechanism complex not completely clear. article reviews proposed tigecycline, view providing references for rational application development new candidate antibiotics.

Language: Английский

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Multi-drug Resistant Acinetobacter baumannii: Phenotypic and Genotypic Resistance Profiles and the Associated Risk Factors in Teaching Hospital in Jordan

Journal of Infection and Public Health, Journal Year: 2024, Volume and Issue: 17(4), P. 543 - 550

Published: Feb. 2, 2024

This study aimed to determine the prevalence of Antimicrobial Resistance Genes (ARGs), with a focus on colistin resistance in clinical A. baumannii, as well risk factors associated baumannii infection Jordanian patients. In total, 150 isolates were obtained from patients at teaching hospital. The tested for antimicrobial susceptibility using disc diffusion and microdilution methods. PCR amplification was used detect ARGs, statistical analysis conducted evaluate influence identified ARGs acquisition. More than 90% resistant monobactam, carbapenem, cephalosporins, Fluoroquinolones, penicillin, β-lactam agents. Moreover, 20.6% (n=31) colistin-resistant. Several also detected isolates. Univariate indicated that carriage significantly P ≤ (0.05) gender, invasive devices, immunodeficiency, systemic diseases, tumors, covid-19. Logistic regression seven factors, three protective (armA, strA, strB) (0.05). contrast, tetB TEM 2 each Our indicates high MDR infections ICU patients, describing case colistin-resistant first time Jordan. Additionally, ARGs-producing among suggest rapid emergence spread without adequate surveillance control measures.

Language: Английский

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Hospital and municipal wastewater as a source of carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa in the environment: a review

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(36), P. 48813 - 48838

Published: July 25, 2024

The increase in the prevalence of carbapenem-resistant Gram-negative bacteria, particular Acinetobacter baumannii (CRAB) and Pseudomonas aeruginosa (CRPA), poses a serious threat for public health worldwide. This article reviews alarming data on infections caused by CRAB CRPA pathogens their presence hospital municipal wastewater, it highlights environmental impact antibiotic resistance. describes key role resistance genes (ARGs) acquisition carbapenem sheds light bacterial mechanisms. main emphasis was placed transfer ARGs not only clinical setting, but also environment, including water, soil, food. aim this review to expand our understanding global risks associated with wastewater analyze spread these micropollutants environment. A literature published last decade will direct research pathogens, support implementation effective preventive measures interventions, contribute development improved strategies managing problem.

Language: Английский

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Machine learning and feature extraction for rapid antimicrobial resistance prediction of Acinetobacter baumannii from whole-genome sequencing data

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 11, 2024

Whole-genome sequencing (WGS) has contributed significantly to advancements in machine learning methods for predicting antimicrobial resistance (AMR). However, the comparisons of different AMR prediction without requiring prior knowledge remains be conducted.

Language: Английский

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Increasing Burden of Antibiotic Resistance in India Due to Co-existence of Multiple Classes of Carbapenem and Different Aminoglycoside Resistance Genes in Clinical Isolates of Acinetobacter baumannii

Current Microbiology, Journal Year: 2025, Volume and Issue: 82(3)

Published: Feb. 6, 2025

Language: Английский

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Using a Difficult-to-treat Resistance Index to Gauge Imbalance between Countries’ Antibiotic Resistance Prevalence and Access to Antibiotics: A Scoping Review and Concept Proposal

Clinical Microbiology and Infection, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Dihydrophenazine: a multifunctional new weapon that kills multidrug-resistant Acinetobacter baumannii and restores carbapenem and oxidative stress susceptibilities

Journal of Applied Microbiology, Journal Year: 2024, Volume and Issue: 135(5)

Published: April 16, 2024

Abstract Aims The current work aims to fully characterize a new antimicrobial agent against Acinetobacter baumannii, which continues represent growing threat healthcare settings worldwide. With minimal treatment options due the extensive spread of resistance almost all available antimicrobials, hunt for agents is high priority. Methods and results An Egyptian soil-derived bacterium strain NHM-077B proved be promising source agent. Bio-guided fractionation culture supernatants followed by chemical structure elucidation identified active as 1-hydroxy phenazine. Chemical synthesis yielded more derivatives, including dihydrophenazine (DHP), most potent A. yet it exhibited marginally safe cytotoxicity profile human skin fibroblasts. Proteomics analysis cells treated with DHP revealed multiple proteins altered expression that could correlated observed phenotypes potential mechanism action DHP. multipronged affects membrane integrity, increases susceptibility oxidative stress, interferes amino acids/protein synthesis, modulates virulence-related proteins. Interestingly, in subinhibitory concentrations re-sensitizes highly virulent carbapenem-resistant baumannii AB5075 carbapenems providing great hope regaining some benefits this important class antibiotics. Conclusions This underscores multifunctional roles both classical nonconventional urgently needed.

Language: Английский

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Geographical mapping and temporal trends of Acinetobacter baumannii carbapenem resistance: A comprehensive meta-analysis

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(12), P. e0311124 - e0311124

Published: Dec. 16, 2024

Background Carbapenem-resistant Acinetobacter baumannii (CRAB) is of critical concern in healthcare settings, leading to limited treatment options. In this study, we conducted a comprehensive meta-analysis assess the prevalence CRAB by examining temporal, geographic, and bias-related variations. Methods We systematically searched prominent databases, including Scopus, PubMed, Web Science, EMBASE. Quality assessment was performed using JBI checklist. Subgroup analyses were based on COVID-19 timeframes, years, countries, continents, bias levels, antimicrobial susceptivity test method guidelines. Results Our meta-analysis, which included 795 studies across 80 countries from 1995 2023, revealed surge carbapenem resistance among A . , imipenem (76.1%), meropenem (73.5%), doripenem (73.0%), ertapenem (83.7%), carbapenems (74.3%). Temporally, 2020–2023 witnessed significant peaks, particularly (81.0%) (80.7%), as confirmed meta-regression, indicating steady upward trend. Conclusion This an alarmingly high rate global challenge, emphasizing urgent need for tailored interventions. Transparency, standardized methodologies, collaboration are crucial accurate maintenance efficacy.

Language: Английский

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