Published: Jan. 1, 2024
Language: Английский
Published: Jan. 1, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 134788 - 134788
Published: Aug. 20, 2024
The long-term use of antibiotics can cause drug resistance. Natural polysaccharides are a novel means treating bacterial infections, and the development utilization litchi pericarp polysaccharide (LPPs) as bacteriostatic active substance offer new research direction for high-value by-products. This study revealed that LPPs inhibited Staphylococcus aureus more than Escherichia coli, Listeria monocytogenes, Salmonella typhimurium, with minimum inhibitory concentrations 145, 205, 325, 445 μg/mL, respectively. activity was insignificant Bacillus subtilis at 505 μg/mL. assessment antibacterial mechanisms influenced growth, conductivity, protein, nucleic acid, reducing sugar, respiratory chain dehydrogenase activity, lipid peroxidation, intracellular adenosine triphosphate, extracellular alkaline phosphatase levels S. aureus. Of note, could modify cell wall integrity membrane permeability aureus, resulting in leakage large small molecules, inhibition cellular metabolism, oxidative losses. These processes exhibited an effect made bacterium nonfunctional, thereby affecting its growth metabolism or causing death. findings provide support insights into potential application natural antimicrobial agent.
Language: Английский
Citations
39Biofilm, Journal Year: 2024, Volume and Issue: 7, P. 100192 - 100192
Published: March 15, 2024
The increasing incidence of antimicrobial resistance exhibited by biofilm-forming microbial pathogens has been recognized as one the major issues in healthcare sector. In present study, nanomaterial-based controlling biofilm and virulence properties considered an alternative approach. Pyoverdine (PVD) isolated from Pseudomonas aeruginosa was utilized a biological corona to synthesize silver nanoparticles (AgNPs), which will be helpful targeted action due recognition pathogenic membrane. Synthesized PVD-AgNPs were spherical irregular, with average size value 251.87 ± 21.8 nm zeta potential −36.51 0.69 mV. MIC towards P. aeruginosa, Listeria monocytogenes, Staphylococcus aureus, Streptococcus mutans, Escherichia coli, Candida albicans standard host-mimicking media observed decreasing order multi-fold, such growth > sputum synthetic human urine saliva. Both initial stage well-established biofilms these have effectively inhibited eradicated PVD-AgNPs. increase susceptibility tetracycline, PVD, amphotericin B established mature mono- mixed-species S. aureus C. albicans. Additionally, attenuate several properties, inhibition protease activity, motility, PVD pyocyanin production aeruginosa. gene expression virulence-associated genes validates its phenotypic effects.
Language: Английский
Citations
31Trends in biotechnology, Journal Year: 2024, Volume and Issue: 42(10), P. 1288 - 1304
Published: April 18, 2024
Language: Английский
Citations
12Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 234, P. 113727 - 113727
Published: Dec. 26, 2023
Language: Английский
Citations
18Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105607 - 105607
Published: March 22, 2024
Language: Английский
Citations
5Animals and zoonoses., Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
5International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140022 - 140022
Published: Jan. 1, 2025
Language: Английский
Citations
0Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
Language: Английский
Citations
0Journal of Proteome Research, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 20, 2025
Staphylococcus aureus (S. aureus) infection has become one of the most common and severe complications among cancer patients. The impact γ radiation from radiotherapy on S. aureus's growth virulence is not yet fully understood. In this study, was exposed to at a dose 100 Gy, its descendants were cultured under normal conditions. Proteome alternations unirradiated, irradiated, irradiated identified by using data-independent acquisition (DIA) proteomic technology. To investigate consequences proteome induced irradiation in aureus, functional enrichment analysis, pathway protein–protein interaction network analysis performed. Differentially expressed proteins (DEPs) primarily enriched lipoteichoic acid biosynthesis, infection, two-component system, cationic antimicrobial peptide resistance, suggesting an enhanced ability. A strong ability typically associated with increased biofilm formation. Both study assay indicate that enhances likely resulting pathogenicity.
Language: Английский
Citations
0Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107485 - 107485
Published: March 1, 2025
Language: Английский
Citations
0