International Journal of Biological Macromolecules, Journal Year: 2017, Volume and Issue: 98, P. 837 - 846
Published: Feb. 14, 2017
Language: Английский
Bone Research, Journal Year: 2017, Volume and Issue: 5(1)
Published: May 30, 2017
Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds tissue-engineering applications, injectable hydrogels have demonstrated great potential use as three-dimensional cell culture in tissue engineering, owing to their high water content, similarity natural extracellular matrix (ECM), porous framework transplantation proliferation, minimal invasive properties, ability match irregular defects. In this review, we describe selection of appropriate biomaterials fabrication methods prepare novel engineering. addition, biology bony ECM is also summarized. Finally, future perspectives are discussed.
Language: Английский
Citations
1055
Drug Design Development and Therapy, Journal Year: 2018, Volume and Issue: Volume 12, P. 3117 - 3145
Published: Sept. 1, 2018
In the last half-century, development of biodegradable polymeric materials for biomedical applications has advanced significantly. Biodegradable are favored in therapeutic devices, including temporary implants and three-dimensional scaffolds tissue engineering. Further advancements have occurred utilization pharmacological such as delivery vehicles controlled/sustained drug release. These require particular physicochemical, biological, degradation properties to deliver effective therapy. As a result, wide range natural or synthetic polymers able undergo hydrolytic enzymatic is being studied applications. This review outlines current various applications, engineering, implants, wound healing, delivery.
Language: Английский
Citations
768
RSC Advances, Journal Year: 2019, Volume and Issue: 9(45), P. 26252 - 26262
Published: Jan. 1, 2019
Bone tissue engineering has been continuously developing since the concept of "tissue engineering" proposed. Biomaterials that are used as basic material for fabrication scaffolds play a vital role in bone engineering. This paper first introduces strategy literature search. Then, it describes structure, mechanical properties and materials natural strategies Particularly, focuses on current knowledge about biomaterials scaffolds, which includes history, types, applications biomaterials. The effects additives such signaling molecules, stem cells, functional performance also discussed.
Language: Английский
Citations
696
Materials Science and Engineering R Reports, Journal Year: 2020, Volume and Issue: 140, P. 100543 - 100543
Published: Feb. 18, 2020
3D printing alias additive manufacturing can transform virtual models created by computer-aided design (CAD) into physical objects in a layer-by-layer manner dispensing with conventional molding or machining. Since the incipiency, significant advancements have been achieved understanding process of and relationship component, structure, property application objects. Because hydrogels are one most feasible classes ink materials for this field has rapidly advancing, Review focuses on hydrogel designs development advanced hydrogel-based biomaterial inks bioinks printing. It covers techniques including laser (stereolithography, two-photon polymerization), extrusion (3D plotting, direct writing), inkjet printing, bioprinting, 4D bioprinting. provides comprehensive overview discussion tailorability material, mechanical, physical, chemical biological properties to enable The range hydrogel-forming polymers covered encompasses biopolymers, synthetic polymers, polymer blends, nanocomposites, functional cell-laden systems. representative biomedical applications selected demonstrate how is being exploited tissue engineering, regenerative medicine, cancer research, vitro disease modeling, high-throughput drug screening, surgical preparation, soft robotics flexible wearable electronics. Incomparable thermoplastics, thermosets, ceramics metals, playing pivotal role creation (bio)systems customizable way. An outlook future directions presented.
Language: Английский
Citations
693
Carbohydrate Polymers, Journal Year: 2016, Volume and Issue: 151, P. 172 - 188
Published: May 19, 2016
Language: Английский
Citations
549
Asian Journal of Pharmaceutical Sciences, Journal Year: 2020, Volume and Issue: 16(3), P. 280 - 306
Published: Nov. 5, 2020
Alginate is an edible heteropolysaccharide that abundantly available in the brown seaweed and capsule of bacteria such as Azotobacter sp. Pseudomonas Owing to alginate gel forming capability, it widely used food, textile paper industries; a lesser extent biomedical applications biomaterial promote wound healing tissue regeneration. This evident from rising use alginate-based dressing for heavily exuding their mass availability market nowadays. However, also has limitation. When contact with physiological environment, could gelate into softer structure, consequently limits its potential soft regeneration becomes inappropriate usage related load bearing body parts. To cater this problem, wide range materials have been added producing sturdy composite materials. For instance, incorporation adhesive peptide natural polymer or synthetic moieties creates improved material, which not only possesses better mechanical properties compared native alginate, but grants additional capability In addition, drug release kinetic cell viability can be further when encapsulating agent. review, preparation various forms (fibre, bead, hydrogel, 3D-printed matrices) application described first, followed by discussion latest trend utilization dressing, delivery, engineering applications.
Language: Английский
Citations
482
Advanced Drug Delivery Reviews, Journal Year: 2016, Volume and Issue: 107, P. 247 - 276
Published: April 29, 2016
Language: Английский
Citations
422
Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(44)
Published: Feb. 5, 2020
Abstract This Review is an overview of the unique characteristics cyclodextrin in forming inclusion complex via host–guest noncovalent interactions. The modification advances its application as a pharmaceutical solubilizer, fabrication functional molecular machines such polyrotaxane, polypseudorotaxane, and polycatenanes grafting with different linear, branched chain polymers. stimuli‐based supramolecular assemblies involving key mediator linked triggering responses on payload release highlighted. In addition, applications diagnostic imaging medical devices briefly demonstrated. Cyclodextrin relatively low cost, biocompatible, biodegradable, highly explored material toxicity for drug formulation, delivery, wide varieties other biomedical those fabrication, biosensor, tissue engineering, bio‐imaging. toxicological profile well established safe human consumption food medicine.
Language: Английский
Citations
407
Carbohydrate Polymers, Journal Year: 2017, Volume and Issue: 168, P. 32 - 43
Published: March 13, 2017
Language: Английский
Citations
405
SN Applied Sciences, Journal Year: 2021, Volume and Issue: 3(1)
Published: Jan. 1, 2021
Abstract Alginate is a polysaccharide of natural origin, which shows outstanding properties biocompatibility, gel forming ability, non-toxicity, biodegradability and easy to process. Due these excellent alginate, sodium hydrogel form oxidized alginate other based materials are used in various biomedical fields, especially drug delivery, wound healing tissue engineering. can be easily processed as the 3D scaffolding includes hydrogels, microcapsules, microspheres, foams, sponges, fibers bio-polymeric have particularly healing, bone injuries, scars, wound, cartilage repair treatment, new regeneration, scaffolds for cell growth. modified blended by adopting some physical chemical processes derivative obtained different structures, functions, having improved mechanical strength, affinity property gelation. This attained due combination with biomaterials, crosslinking, immobilization definite ligands (sugar peptide molecules). Hence its forms, composite found more attractive towards article provides comprehensive outline properties, structural aspects, application
Language: Английский
Citations
348