Gut Microbes,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: May 20, 2025
Metabolic
Dysfunction-Associated
Steatotic
Liver
Disease(MASLD)
is
increasing
in
prevalence
worldwide
and
has
become
the
greatest
potential
risk
for
cirrhosis
hepatocellular
liver
cancer.
Currently,
role
of
gut
microbiota
development
MASLD
a
research
hotspot.
The
can
affect
homeostasis
microbiota,
significant
changes
composition
or
abundance
its
metabolite
abnormalities
influence
disease
progression.
regulation
an
important
strategy
novel
target
treatment
with
good
prospects.
In
this
paper,
we
summarize
metabolites
pathogenesis
MASLD,
describe
preventive
therapeutic
efficacy
as
noninvasive
marker
to
regulate
based
on
"gut-hepatic
axis",
which
will
provide
new
ideas
clinic.
Ultrasonics Sonochemistry,
Journal Year:
2023,
Volume and Issue:
98, P. 106507 - 106507
Published: June 28, 2023
In
this
study,
Shatian
pomelo
peel
was
used
as
the
raw
material
for
extracting
polysaccharides
using
hot
water
extraction
(HW)
and
ultrasonic-assisted
enzyme
(UVE)
methods,
respectively.
The
optimal
parameters
extractingShatian
(StPP)
ultrasound-assisted
enzymatic
method
were
determined
response
surface
methodology
(RSM).
conditions
of
StPP
follows:
ultrasound
power
350
W,
time
50
min,
digestion
compound
addition
1.5%,
temperature
55
°C.
yield
found
to
be
30.1310%
under
these
conditions.
Comparing
physicochemical
properties
antioxidant
activity
extracted
different
it
observed
that
resulted
in
higher
yield,
sugar
content
glucuronic
acid
compared
traditional
extraction.
Additionally,
by
showed
better
activity.
These
results
suggest
is
an
effective
enhance
natural
polysaccharides.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(16), P. 3852 - 3852
Published: Aug. 14, 2024
Medicinal
food
varieties
developed
according
to
the
theory
of
medical
and
edible
homologues
are
effective
at
preventing
treating
chronic
diseases
in
health
care.
As
2022,
110
types
traditional
Chinese
medicines
from
same
source
medicine
have
been
published
by
National
Health
Commission.
Inflammation
is
immune
system’s
first
response
injury,
infection,
stress.
Chronic
inflammation
closely
related
many
such
as
atherosclerosis
cancer.
Therefore,
timely
intervention
for
mainstay
treatment
other
complex
diseases.
However,
some
anti-inflammatory
drugs
on
market
commonly
associated
with
a
number
adverse
effects,
which
seriously
affect
safety
patients.
in-depth
development
new
safe,
harmless,
has
become
hot
topic
research
an
urgent
clinical
need.
Polysaccharides,
one
main
active
ingredients
homologous
(MEHTCMs),
confirmed
large
studies
exert
effects
through
multiple
targets
considered
potential
natural
drugs.
In
addition,
structure
medicines’
polysaccharides
(MEHTCMPs)
may
be
key
factor
determining
their
activity,
makes
underlying
structure–efficacy
relationship
topics
domestic
international
research.
due
limitations
current
analytical
techniques
tools,
structures
not
fully
elucidated
relatively
ambiguous,
difficulties
process
developing
utilizing
MEHTCMPs
novel
future.
For
this
reason,
paper
summarizes
mechanisms
MEHTCMPs,
regulation
Toll-like
receptor-related
signaling
pathway,
MAPK
JAK-STAT
NLRP3
PI3K-AKT
PPAR-γ
Nrf2-HO-1
intestinal
flora,
it
systematically
analyzes
evaluates
relationships
between
activity
structures.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(1), P. 196 - 196
Published: Jan. 6, 2025
Pueraria
montana
var.
lobata
(Willd.)
Maesen
&
S.M.Almeida
ex
Sanjappa
Predeep
(P.
lobata)
is
a
medicinal
herb
widely
used
in
the
food
and
pharmaceutical
industries,
studies
have
shown
that
P.
possesses
significant
anti-inflammatory
pharmacological
activities.
In
this
paper,
total
of
16
compounds
were
isolated
identified
from
lobata,
among
which
1–3,
7,
14,
for
first
time.
The
results
an
vitro
activity
screening
assay
showed
1,
4,
6,
8,
15
able
to
significantly
reduce
levels
pro-inflammatory
cytokines
IL-6
IL-1β
LPS-induced
RAW264.7
macrophages,
with
most
obvious
effect
produced
by
compound
6
(formononetin),
while
formononetin
was
number
macrophages
at
site
inflammation
transgenic
zebrafish.
addition,
network
analysis
revealed
closely
related
autophagy
polarization
targets
such
as
TNF,
EGFR,
PTGS2,
ESR1.
validation
experiments
could
enhance
expression
LCII/LCI
P62
protein,
CD86,
CD206,
further
indicated
regulating
macrophage
processes.
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
unknown
Published: March 31, 2023
Alcoholic
liver
disease
(ALD)
has
emerged
as
an
important
public
health
problem
in
the
world.
The
polyphenols,
protein,
peptides,
and
polysaccharides
have
attracted
attention
for
prevention
or
treatment
of
ALD.
Therefore,
this
paper
reviews
pathogenesis
ALD,
relationship
between
polysaccharides,
expounds
mechanism
gut
microbiota
on
protecting
It
is
mainly
found
that
hydroxyl
group
polyphenols
endows
it
with
antioxidation
to
protect
ALD
protection
bioactive
peptides
related
amino
acid
composition.
primary
structure.
Meanwhile,
prevent
treat
by
antioxidation,
anti-inflammatory,
antiapoptosis,
lipid
metabolism,
regulation.
This
contribution
provides
updated
information
response
which
will
not
only
facilitate
development
novel
components
but
also
future
application
functional
food
raw
materials
be
promoted.
