Sustained in vitro delivery of metformin-loaded mesoporous silica nanoparticles for delayed senescence and stemness preservation of adipose-derived stem cells DOI
Mehdi Dadashpour,

Hamed Mahmoudi,

Zahra Rahimi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 87, P. 104769 - 104769

Published: July 20, 2023

Language: Английский

Solubilization techniques used for poorly water-soluble drugs DOI Creative Commons

Bing Xie,

Yaping Liu, Xiaotong Li

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4683 - 4716

Published: Sept. 2, 2024

About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.

Language: Английский

Citations

21
Conception of pH-sensitive calcium alginate/poly vinyl alcohol hydrogel beads for controlled oral curcumin delivery systems. Antibacterial and antioxidant properties DOI

Zineb Touzout,

Naima Abdellaoui, Assia Siham Hadj‐Hamou

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 263, P. 130389 - 130389

Published: Feb. 24, 2024

Language: Английский

Citations

19
Curcumin delivery and co-delivery based on nanomaterials as an effective approach for cancer therapy DOI
Mehrab Pourmadadi, Parisa Abbasi,

Mohammad Mahdi Eshaghi

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2022, Volume and Issue: 78, P. 103982 - 103982

Published: Nov. 12, 2022

Language: Английский

Citations

45
Efficient Delivery of Curcumin by Alginate Oligosaccharide Coated Aminated Mesoporous Silica Nanoparticles and In Vitro Anticancer Activity against Colon Cancer Cells DOI Creative Commons

Chennan Liu,

Fangyuan Jiang,

Zifeng Xing

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(6), P. 1166 - 1166

Published: May 30, 2022

We designed and synthesized aminated mesoporous silica (MSN-NH2), functionally grafted alginate oligosaccharides (AOS) on its surface to get MSN-NH2-AOS nanoparticles as a delivery vehicle for the fat-soluble model drug curcumin (Cur). Dynamic light scattering, thermogravimetric analysis, X-ray photoelectron spectroscopy were used characterize structure performance of MSN-NH2-AOS. The nano-MSN-NH2-AOS preparation process was optimized, loading encapsulation efficiencies investigated. efficiency MSN-NH2-Cur-AOS up 91.24 ± 1.23%. pH-sensitive AOS coating made total release rate Cur only 28.9 1.6% under neutral conditions 67.5 1% acidic conditions. According results in vitro anti-tumor studies conducted by MTT cellular uptake assays, more easily absorbed colon cancer cells than free Cur, achieving high tumor cell targeting efficiency. Moreover, when concentration reached 50 μg/mL, showed strong cytotoxicity against cells, indicating that might be promising tool novel anticancer carrier.

Language: Английский

Citations

43
Curcumin-loaded mesoporous silica nanoparticles for drug delivery: synthesis, biological assays and therapeutic potential – a review DOI Creative Commons
Milad Iranshahy, Mohammad Yahya Hanafi‐Bojd, Seyed Hadi Aghili

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(32), P. 22250 - 22267

Published: Jan. 1, 2023

Curcumin-loaded mesoporous silica nanoparticles (MSNs) have shown promise as drug delivery systems to address the limited pharmacokinetic characteristics of curcumin. Functionalization with folic acid and PEGylation enhance anticancer activity, biocompatibility, stability, permeability. Co-delivery other drugs results in synergistically enhanced cytotoxic activity. Environment-responsive MSNs prevent undesirable leakage increase selectivity towards target tissues. This review summarizes methods Cur-loaded MSN synthesis functionalization their application various diseases, also highlights potential a promising system.

Language: Английский

Citations

35
Redox and pH dual sensitive carboxymethyl chitosan functionalized polydopamine nanoparticles loaded with doxorubicin for tumor chemo-photothermal therapy DOI
Yanfei Zhu, Junhong Ling, Xinyi Xu

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 240, P. 124488 - 124488

Published: April 17, 2023

Language: Английский

Citations

31
In situ generation of copper(Ⅱ)/diethyldithiocarbamate complex through tannic acid/copper(Ⅱ) network coated hollow mesoporous silica for enhanced cancer chemodynamic therapy DOI
Yanfei Zhu, Nan Wang, Junhong Ling

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 660, P. 637 - 646

Published: Jan. 21, 2024

Language: Английский

Citations

14
pH-Sensitive Stimulus Responsive ZIF-8 Composites Nanoparticles Coated with Folic Acid-Conjugated Chitosan for Targeted Delivery of Curcumin DOI

Honghuan Luo,

Menglan Chen,

Fangxiang Song

et al.

Journal of Cluster Science, Journal Year: 2024, Volume and Issue: 35(5), P. 1533 - 1547

Published: April 6, 2024

Language: Английский

Citations

10
A pH-sensitive silica nanoparticles for colon-specific delivery and controlled release of catechin: Optimization of loading efficiency and in vitro release kinetics DOI Creative Commons
Abdulsalam M. Kassem,

May Almukainzi,

Tarek M. Faris

et al.

European Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 192, P. 106652 - 106652

Published: Nov. 25, 2023

Catechin is a naturally occurring flavonoid of the flavan-3-ol subclass with numerous biological functions; however, these benefits are diminished due to several factors, including low water solubility and degradation in stomach's harsh environment. So, this study aimed develop an intelligent catechin colon-targeting delivery system high loading capacity. This was done by coating surface-decorated mesoporous silica nanoparticles pH-responsive enteric polymer called Eudragit®-S100. The pristine wormlike (< 100 nm) surface area large total pore volume were effectively synthesized modified NH2 group using post-grafting strategy. Various parameters, solvent polarity, catechin-carrier mass ratio, adsorption time, studied improve into aminated nanoparticles. Next, negatively charged Eudragit®-S100 electrostatically coated onto positively nanocarriers shield loaded from acidic environment stomach (pH 1.9) facilitate site-specific colon 7.4). prepared nanomaterials evaluated methods, Brauner-Emmett-Teller, analyzer, zeta sizer, Field Emission Scanning Electron Microscope, Powder X-Ray Diffraction, Fourier Transform Infrared Spectroscopy, Energy-Dispersive X-ray Differential Calorimetry. In vitro dissolution studies revealed that Eudragit®-S100-coated prevented burst release environment, approximately 90% only being released at colonic pH > 7) supercase II transport mechanism. As result, would provide innovative promising approach targeted nanomedicine for oral related medicines treating diseases colon, such as colorectal cancer irritable bowel syndrome.

Language: Английский

Citations

18
MnO2 modified hollow mesoporous silica nanoparticles for enhanced chemodynamic therapy DOI
Zhen Liu, Yuhuan He, Junhong Ling

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 95, P. 105604 - 105604

Published: March 21, 2024

Language: Английский

Citations

7