Effects of moderate beer consumption on immunity and the gut microbiome in immunosuppressed mice DOI Open Access
Shumin Hu, Hua Yin,

Xiaxia LI

et al.

Bioscience of Microbiota Food and Health, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Beer contains a variety of bioactive ingredients and trace elements that can regulate bodily functions, moderate consumption beer enhance immune responses. This study aimed to investigate the potential benefits alcoholic or non-alcoholic on gut microbiome, immunity, intestinal barrier function in immunosuppressed BALB/c mice induced by cyclophosphamide (CTX). Model with CTX-induced immunosuppression were administered galacto-oligosaccharides (GOS) for 28 consecutive days. The GOS intervention groups all showed alleviation spleen tissue damage, an increased organ index, decreased inflammation, reduced serum concentrations D-lactic acid, lipopolysaccharide, tumor necrosis factor α. High-throughput 16S rRNA gene sequencing revealed higher relative abundances Firmicutes Actinobacteriota, lower Bacteroidota, Lactobacillus, Bifidobacterium, CTX than normal control mice. In addition, abundance, while Desulfobacterota abundance intake without it. Spearman correlation analysis indicated Bacteroidota was negatively correlated propionic acid butyric positively acid. Proteobacteria acetic isobutyric valeric Helicobacter conclusion, this is one first studies examine modulatory effects alcohol immunocompromised Our findings indicate alter microbiome metabolites, enhancing immunity

Language: Английский

Sodium Alginate Prevents Non-Alcoholic Fatty Liver Disease by Modulating the Gut–Liver Axis in High-Fat Diet-Fed Rats DOI Open Access
Hui Zhao, Xiang Gao,

Zhizuo Liu

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(22), P. 4846 - 4846

Published: Nov. 16, 2022

Previous studies have suggested that the sodium alginate (SA) is beneficial for treatment of non-alcoholic fatty liver disease (NAFLD), while potential mechanisms are largely unknown. The present study aimed to clarify effects and SA in preventing NAFLD via gut−liver axis. Thirty-two male Sprague−Dawley rats were randomly divided into four groups: normal control group (NC); high-fat diet (HFD); HFD with 50 mg/kg/d (LSA); 150 (HSA). After 16 weeks, scarified collect blood tissues. results indicated significantly reduced their body weight, hepatic steatosis, serum triglyceride (TG), alanine transaminase (ALT) tumor necrosis factor α (TNF-α) levels increased high-density lipoprotein-cholesterol (HDL-C) comparison (p < 0.05). elevated mRNA protein expression genes related toll-like receptor 4 (TLR-4)/nuclear factor-kappa B (NF-κB)/nod-like 3 (NLRP3) inflammatory signaling pathway HFD-fed was notably suppressed by SA. In terms gut microbiota, LSA showed a higher fecal abundance Oscillospiraceae_UCG_005, Butyricicoccaceae_UCG_009 Colidextribacter compared HSA had unclassified_Lachnospiraceae, Oscillibacter HFD-associated community addition, treated significant increase short chain acids (SCFAs) decline lipopolysaccharide (LPS) Moreover, modulated bacteria microbial metabolites correlated amelioration NAFLD-related indices activation TLR4/NF-κB/NLRP3 pathway. conclusion, prevented mechanism modulation

Language: Английский

Citations

34
A cold-water extracted polysaccharide-protein complex from Grifola frondosa exhibited anti-tumor activity via TLR4-NF-κB signaling activation and gut microbiota modification in H22 tumor-bearing mice DOI
Jiahui Zhao, Rongjun He,

Hao Zhong

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 239, P. 124291 - 124291

Published: April 5, 2023

Language: Английский

Citations

15
Antidiabetic effect of sciadonic acid on type 2 diabetic mice through activating the PI3K-AKT signaling pathway and altering intestinal flora DOI Creative Commons
Lin Chen,

Qihong Jiang,

Hongling Lu

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 23, 2022

Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by hyperglycemia. The aim of this work was to investigate the effect sciadonic acid (SA) on disorders glucolipid metabolism and intestinal flora imbalance further its potential molecular mechanism anti-diabetes. experimental data indicated that SA could alleviate hyperlipidemia, insulin resistance, oxidative stress, inflammatory response, repair liver function damage, promote glycogen synthesis caused T2DM. also activate PI3K/AKT/GLUT-2 signaling pathway, glucose gene expression, maintain homeostasis. Furthermore, 16S rRNA analysis revealed reduce Firmicutes/Bacteroidota (F/B) ratio; norank_f__Muribaculaceae, Allobaculum, Akkermansia, Eubacterium_siraeum_group proliferation; increase levels major short-chain fatty acids (SCFAs), such as acetic acid, propionic butyric acid; homeostasis flora. In conclusion, these results suggested reshape structural composition microbes, PI3K/AKT/GLUT2 improve decrease blood levels.

Language: Английский

Citations

21
Study effect and mechanism of levofloxacin on the neurotoxicity of Rana nigromaculata tadpoles exposed to imidacloprid based on the microbe-gut-brain axis DOI
Wenjun Zhang,

Miaomiao Teng,

Jin Yan

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 872, P. 162098 - 162098

Published: Feb. 8, 2023

Language: Английский

Citations

11
Lactobacillus plantarumHF02 alleviates lipid accumulation and intestinal microbiota dysbiosis in high‐fat diet‐induced obese mice DOI
Haoran Chen,

Haiding Zhao,

Xiaofen Qi

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2023, Volume and Issue: 103(9), P. 4625 - 4637

Published: March 3, 2023

Obesity is closely associated with lipid accumulation and intestinal microbiota dysbiosis. It has been proved that probiotics supplement contributes to alleviate obesity. The objective of this study was investigate the mechanism by which Lactobacillus plantarum HF02 (LP-HF02) alleviated dysbiosis in high-fat diet-induced obese mice.Our results showed LP-HF02 ameliorated body weight, dyslipidemia, liver accumulation, injury mice. As expected, inhibited pancreatic lipase activity small contents increased fecal triglyceride levels, thereby reducing dietary fat hydrolysis absorption. Moreover, composition, as evidenced enhanced ratio Bacteroides Firmicutes, decreased abundance pathogenic bacteria (including Bacteroides, Alistipes, Blautia, Colidextribacter) beneficial Muribaculaceae, Akkermansia, Faecalibaculum, Rikenellaceae_RC9_gut_group). also short-chain fatty acids (SCFAs) levels colonic mucosal thickness, subsequently serum lipopolysaccharide (LPS), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) Additionally, reverse transcription quantitative polymerase chain reaction (RT-qPCR) Western blot demonstrated hepatic via activating adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway.Therefore, our indicated could be considered a probiotic preparation for preventing © 2023 Society Chemical Industry.

Language: Английский

Citations

11
Reshaping the Gut Microbiota: Tangliping Decoction and Its Core Blood-Absorbed Component Quercetin Improve Diabetic Cognitive Impairment DOI

Wenlan Zhang,

Chunmei Yi,

Zhijie Song

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156560 - 156560

Published: March 5, 2025

Language: Английский

Citations

0
Biological activities and health benefits of sodium alginate: A review DOI
Xinru Li, Yi Qiao, Hui Liu

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 129, P. 106856 - 106856

Published: April 28, 2025

Language: Английский

Citations

0
Enhanced Antioxidative Capacity Transfer between Sow and Fetus via the Gut–Placenta Axis with Dietary Selenium Yeast and Glycerol Monolaurate Supplementation during Pregnancy DOI Creative Commons
Jiawen Zhang, Jun Wang, Ziwei Ma

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(2), P. 141 - 141

Published: Jan. 23, 2024

This study aims to investigate the impact of dietary supplementation with selenium yeast (SeY) and glycerol monolaurate (GML) on transfer antioxidative capacity between mother fetus during pregnancy its underlying mechanisms. A total 160 sows similar body weight parity 3–6 were randomly uniformly allocated four groups (n = 40) as follows: CON group, SeY GML SG (SeY + GML) group. Animal feeding started from 85th day gestation continued delivery. The resulted in increased placental reduced lipopolysaccharide (LPS) levels sow plasma, tissues, piglet plasma. Furthermore, redox balance inflammatory markers exhibited significant improvements plasma fed either or GML, well their offspring. Moreover, addition activated Nrf2 signaling pathway, while downregulating expression pro-inflammatory genes proteins associated pathways (MAPK NF-κB). Vascular angiogenesis nutrient transportation (amino acids, fatty glucose) upregulated, whereas apoptosis within placenta downregulated GML. integrity intestinal barriers significantly improved, indicated by ZO-1, occludin, claudin-1, along DLA DAO treatment. abundance Christensenellaceae_R-7_group, Clostridium_sensus_stricto_1, Bacteroidota, decreasing gut microbiota metabolites LPS trimethylamine N-oxide. Correlation analysis demonstrated a negative relationship weight, oxidative stress, inflammation. In summary, enhanced maternal-fetal via gut–placenta axis through modulating composition.

Language: Английский

Citations

3
Effects of metformin, saxagliptin and repaglinide on gut microbiota in high-fat diet/streptozocin-induced type 2 diabetic mice DOI Creative Commons

Yangchen Tang,

Mengli Yan,

Zemin Fang

et al.

BMJ Open Diabetes Research & Care, Journal Year: 2024, Volume and Issue: 12(3), P. e003837 - e003837

Published: May 1, 2024

Introduction There has been increasing evidence that the gut microbiota is closely related to type 2 diabetes (T2D). Metformin (Met) often used in combination with saxagliptin (Sax) and repaglinide (Rep) for treatment of T2D. However, little known about effects these agents on Research design methods A T2D mouse model induced by a high-fat diet (HFD) streptozotocin (STZ) was employed. The mice were randomly divided into six groups, including sham, Met, Sax, Rep, Met+Sax Met+Rep, 4 weeks. Fasting blood glucose level, serum biochemical index, H&E staining liver, Oil red O liver analysis 16s sequencing access fecal samples. Results These antidiabetics effectively prevented development HFD/STZ-induced high glucose, had better effect inhibiting lipid accumulation. All dosing regimens restored decreasing ratio phylum Bacteroidetes: Firmicutes, abundance Desulfobacterota, expect Met. At genus Muribaculaceae mice, but when Met combined Rep or decreased. could restore reduced Prevotellaceae_UCG-001, while monotherapy no such effect. In addition, Lachnospiraceae_NK4A136_group well much greater than corresponding group. Therefore, exerted different composition microbiota, which might be associated Conclusions Supplementation specific probiotics may further improve hypoglycemic helpful new therapeutic drugs

Language: Английский

Citations

3
Protective Effects of Fucoidan on Iodoacetamide-Induced Functional Dyspepsia via Modulation of 5-HT Metabolism and Microbiota DOI Open Access
Tianxu Liu, Muyuan Ma, Yonglin Wu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3273 - 3273

Published: April 1, 2025

As the major polysaccharide in brown algae, fucoidan possesses broad biological abilities and has been reported to improve gastrointestinal health. Functional dyspepsia, a common non-organic disease, is complex of symptoms mainly characterized by pathogenesis, such as visceral hypersensitivity, gastric dysmotility, inflammation. To date, effects regulating functional dyspepsia with sensitivity remains unclear. In current study, iodoacetamide was employed establish mouse model hypersensitivity. Meanwhile, orally administrated for fourteen days. Indicators were conducted evaluate potential ingredient complementary alternative medicine levels serum hormones, expression receptors, gut microbial profile. The results show that oral administration led significant reductions secretion 5-hydroxytryptamine, cortisol, corticosterone. Additionally, it decreased 5-hydroxytryptamine-3 regulation 5-hydroxytryptamine metabolism improvement imbalance. above suggest could ameliorate hypersensitivity modulating 5-HT microbiota. findings indicate component adjuvant treatment its expanded utilization food medical fields.

Language: Английский

Citations

0