Advanced Drug Delivery Reviews,
Journal Year:
2023,
Volume and Issue:
197, P. 114822 - 114822
Published: April 21, 2023
Central
nervous
system
(CNS)
disorders
affect
as
many
1.5
billion
people
globally.
The
limited
delivery
of
most
imaging
and
therapeutic
agents
into
the
brain
is
a
major
challenge
for
treatment
CNS
disorders.
With
advent
nanotechnologies,
controlled
drugs
with
nanoparticles
holds
great
promise
in
overcoming
blood-brain
barrier
(BBB)
improving
efficacy.
In
recent
years,
magnetic
iron
oxide
(MIONPs)
have
stood
out
promising
theranostic
nanoplatform
drug
they
possess
unique
physical
properties
biodegradable
characteristics.
this
review,
we
summarize
advances
MIONP-based
platforms
diseases.
We
firstly
introduce
methods
synthesis
surface
functionalization
MIONPs
emphasis
on
inclusion
biocompatible
polymers
that
allow
addition
tailored
physicochemical
properties.
then
discuss
vivo
applications
using
MIONPs.
Finally,
present
perspective
remaining
challenges
possible
future
directions
systems.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(6), P. 3169 - 3189
Published: April 14, 2024
Abstract
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
the
accumulation
of
amyloid‐beta
plaques
and
neurofibrillary
tangles,
leading
to
neuronal
loss.
Curcumin,
polyphenolic
compound
derived
from
Curcuma
longa
,
has
shown
potential
neuroprotective
effects
due
its
anti‐inflammatory
antioxidant
properties.
This
review
aims
synthesize
current
preclinical
data
on
anti‐neuroinflammatory
mechanisms
curcumin
in
context
AD,
addressing
pharmacokinetics,
bioavailability,
as
therapeutic
adjunct.
An
exhaustive
literature
search
was
conducted,
focusing
recent
studies
within
last
10
years
related
curcumin's
impact
neuroinflammation
role
AD.
The
methodology
included
sourcing
articles
specialized
databases
using
specific
medical
subject
headings
terms
ensure
precision
relevance.
Curcumin
demonstrates
significant
properties
modulating
neuroinflammatory
pathways,
scavenging
reactive
oxygen
species,
inhibiting
production
pro‐inflammatory
cytokines.
Despite
potential,
challenges
remain
regarding
limited
bioavailability
scarcity
comprehensive
human
clinical
trials.
emerges
promising
adjunct
AD
multimodal
benefits.
However,
further
research
required
overcome
establish
effective
dosing
regimens
subjects.
Developing
novel
delivery
systems
formulations
may
enhance
treatment.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(4), P. 481 - 481
Published: April 1, 2024
The
nose-to-brain
drug-delivery
system
has
emerged
as
a
promising
strategy
to
overcome
the
challenges
associated
with
conventional
drug
administration
for
central
nervous
disorders.
This
emerging
field
is
driven
by
anatomical
advantages
of
nasal
route,
enabling
direct
transport
drugs
from
cavity
brain,
thereby
circumventing
blood–brain
barrier.
review
highlights
significance
features
cavity,
emphasizing
its
high
permeability
and
rich
blood
supply
that
facilitate
rapid
absorption
onset
action,
rendering
it
domain
neurological
therapeutics.
Exploring
recent
developments
innovations
in
different
nanocarriers
such
liposomes,
polymeric
nanoparticles,
solid
lipid
dendrimers,
micelles,
nanoemulsions,
nanosuspensions,
carbon
nanotubes,
mesoporous
silica
nanogels
unveils
their
diverse
functions
improving
efficiency
targeting
specificity
within
this
system.
To
minimize
potential
risk
nanoparticle-induced
toxicity
mucosa,
article
also
delves
into
latest
advancements
formulation
strategies
commonly
involving
surface
modifications,
incorporating
cutting-edge
materials,
adjustment
particle
properties,
development
novel
formulations
improve
stability,
release
kinetics,
specificity.
These
approaches
aim
enhance
while
minimizing
adverse
effects.
hold
catalyze
advancement
safer
more
efficient
systems,
consequently
revolutionizing
treatments
provides
valuable
resource
researchers,
clinicians,
pharmaceutical-industry
professionals
seeking
advance
effective
safe
therapies
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 746 - 746
Published: Feb. 23, 2023
Nanomedicine
is
currently
focused
on
the
design
and
development
of
nanocarriers
that
enhance
drug
delivery
to
brain
address
unmet
clinical
needs
for
treating
neuropsychiatric
disorders
neurological
diseases.
Polymer
lipid-based
carriers
are
advantageous
central
nervous
system
(CNS)
due
their
safety
profiles,
drug-loading
capacity,
controlled-release
properties.
nanoparticles
(NPs)
reported
penetrate
blood–brain
barrier
(BBB)
have
been
extensively
assessed
in
vitro
animal
models
glioblastoma,
epilepsy,
neurodegenerative
disease.
Since
approval
by
Food
Drug
Administration
(FDA)
intranasal
esketamine
treatment
major
depressive
disorder,
administration
has
emerged
as
an
attractive
route
bypass
BBB
CNS.
NPs
can
be
specifically
designed
tailoring
size
coating
with
mucoadhesive
agents
or
other
moieties
promote
transport
across
nasal
mucosa.
In
this
review,
unique
characteristics
polymeric
desirable
explored
addition
potential
repurposing
CNS
disorders.
Progress
using
nanostructures
treatments
various
diseases
also
described.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(4), P. 3390 - 3390
Published: Feb. 8, 2023
Intranasal
(IN)
drug
delivery
is
a
non-invasive
and
effective
route
for
the
administration
of
drugs
to
brain
at
pharmacologically
relevant
concentrations,
bypassing
blood–brain
barrier
(BBB)
minimizing
adverse
side
effects.
IN
can
be
particularly
promising
treatment
neurodegenerative
diseases.
The
mechanism
involves
initial
penetration
through
nasal
epithelial
barrier,
followed
by
diffusion
in
perivascular
or
perineural
spaces
along
olfactory
trigeminal
nerves,
final
extracellular
throughout
brain.
A
part
may
lost
drainage
lymphatic
system,
while
even
enter
systemic
circulation
reach
crossing
BBB.
Alternatively,
directly
transported
axons
nerve.
To
improve
effectiveness
route,
various
types
nanocarriers
hydrogels
their
combinations
have
been
proposed.
This
review
paper
analyzes
main
biomaterials-based
strategies
enhance
brain,
outlining
unsolved
challenges
proposing
ways
address
them.
Journal of Drug Delivery Science and Technology,
Journal Year:
2024,
Volume and Issue:
95, P. 105564 - 105564
Published: March 12, 2024
The
nasal
route
has
routinely
been
used
in
the
local
delivery
of
drugs,
however
with
innovations
nanotechnology,
there
increased
interest
exploring
this
more
for
systemic,
and
brain/CNS
delivery.
This
is
because
safe,
non-invasive,
medications
can
be
self-administered
to
achieve
rapid
therapeutic
drug
levels
minimal
doses.
Polymeric
nanoparticles
(NPs)
such
as
PLGA
NPs
have
a
wide
range
applications
delivery,
due
their
large
surface
area
modification
targeting
ligands
polymers
which
enhances
cellular
uptake,
bioavailability
at
target
sites.
review
covers
recent
research
on
use
small
molecule
drugs
macromolecules
via
route.
It
some
background
information
about
challenges
delivering
most
common
polymer
coatings
are
highlighted.
Finally,
patents
clinical
trials
also
covered.
