Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101386 - 101386
Published: Dec. 9, 2024
Language: Английский
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101626 - 101626
Published: March 1, 2025
Cancer treatment is challenged by the tumor microenvironment (TME), which promotes drug resistance and cancer cell growth. This review offers a comprehensive innovative perspective on how nanomedicine can modify TME to enhance therapy. Strategies include using nanoparticles improve oxygenation, adjust acidity, alter extracellular matrix, making treatments more effective. Additionally, immune responses activating cells reducing suppression within tumors. By integrating these approaches with existing therapies, such as chemotherapy radiotherapy, show promise in overcoming traditional barriers. The discusses changes effectiveness of itself, creating reciprocal relationship that boosts overall efficacy. We also highlight novel strategies aimed at exploiting TME, leveraging nanoparticle-based for targeted therapy through precise modulation.
Language: Английский
Citations
2
Materials Today Communications, Journal Year: 2025, Volume and Issue: 45, P. 112260 - 112260
Published: March 18, 2025
Language: Английский
Citations
1
Designed Monomers & Polymers, Journal Year: 2024, Volume and Issue: 28(1), P. 1 - 34
Published: Dec. 31, 2024
This review paper analyzes recent advancements in bio-polymer coatings for probiotic microencapsulation, with a particular emphasis on chitosan and its synergistic combinations other materials. Probiotic microencapsulation is essential protecting probiotics from environmental stresses, enhancing their stability, ensuring effective delivery to the gut. The begins an overview of highlighting significance safeguarding through processing, storage, gastrointestinal transit. Advances chitosan-based encapsulation are explored, including integration bio-polymers such as alginate, gelatin, pectin, well application nanotechnology innovative techniques like spray drying layer-by-layer assembly. Detailed mechanistic insights integrated, illustrating how influences gut microbiota by promoting beneficial bacteria suppressing pathogens, thus role prebiotic or synbiotic. Furthermore, delves into chitosan's immunomodulatory effects, particularly context inflammatory bowel disease (IBD) autoimmune diseases, describing immune signaling pathways influenced linking changes improvements systemic immunity. Recent clinical trials human studies assessing efficacy chitosan-coated presented, alongside discussion practical applications comparison vitro vivo findings highlight real-world relevance. sustainability sources impact addressed, along novel concept gut-brain axis. Finally, emphasizes future research needs, development personalized therapies exploration techniques.
Language: Английский
Citations
5
Journal of Nanoparticle Research, Journal Year: 2024, Volume and Issue: 26(9)
Published: Sept. 1, 2024
Language: Английский
Citations
4
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124994 - 124994
Published: Nov. 1, 2024
Language: Английский
Citations
4
Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Polymer-based herbicide nanocarriers have shown potential for increasing the efficacy and environmental safety. This study aimed to develop, characterize, evaluate toxicity target nontarget organisms of natural-based polymeric nanosystems glyphosate. Polymers such as chitosan (CS), zein (ZN), lignin (LG) were used in synthesis. Nanosystem size, surface charge, polydispersity index, encapsulation efficiency, weed species (Amaranthus hybridus, Ipomoea grandifolia, Eleusine indica), Roundup Ready (RR) crops, soil respiration, enzyme activity evaluated. The most stable system was combination ZN with cross-linker poloxamer (PL), higher control (90–96%) A. compared commercial glyphosate (40%). No improvement observed I. grandifolia E. indica. RR or enzymes, indicating no toxic effects nanoformulation these models. ZN-PL systems can be a promising alternative delivery, using environmentally friendly materials, improved efficiency agriculture.
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101539 - 101539
Published: Feb. 1, 2025
The treatment outcomes of traditional patches for chronic soft tissue defects (CSTDs) are unsatisfactory in clinical, owing to the lack intrinsic bioactivities orchestrate intricate regenerative process. To tackle this deficiency, nature-derived microneedles (NMs) composed silk methacrylate and snail mucus developed study. resultant NMs have excellent mechanical strength biological adhesiveness, ensuring suture-free but reliable fixation on implanted site. enhance bioactivities, metal-polyphenolic networks (MPNs) coordinated from copper (Cu) curcumin (Cur) designed encapsulated into NMs. Cu-Cur MPNs harness anti-oxidative anti-inflammatory properties Cur with pro-angiogenic Cu, targeting different negative aspects CSTDs repair. Furthermore, pH-responsive disassembly can respond acidic microenvironment, allowing burst-free on-demand drug delivery. Both in-vitro in-vivo experiments demonstrate that encapsulation (Cu-Cur-NMs) restore redox homeostasis, reduce inflammatory response, promote blood vessel formation, thus remodeling microenvironment greatly improve repair quality CSTDs. Therefore, combined advantages microneedles-based patch system MPNs-based nanotherapeutic agent explored first time, our proposed Cu-Cur-NMs represent a multifunctional promising device
Language: Английский
Citations
0
Chemistry - Methods, Journal Year: 2025, Volume and Issue: unknown
Published: March 21, 2025
Abstract Block copolymer self‐assembly into nanoparticles of defined size and morphology is facilitated via continuous flow synthesis methods. Using flow, are obtained at higher rates, with improved consistency, under greener conditions significantly reduced batch‐to‐batch variability when compared to traditional batch processes. The methodology formulate block copolymers in a setup described, design strategies explained. Further, the purification particles dialysis marking second important step synthesis, which performed time resource intensive. described methods open pathway for reproducible nanoparticle towards automation high‐throughput screening materials.
Language: Английский
Citations
0
Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 1, 2025
Abstract Background Tuberculosis (TB) is a contagious disease and the second leading cause of death worldwide. The Bacille Calmette–Guérin (BCG) vaccine, only licensed TB has insufficient protective efficacy in adults, necessitating development new vaccines. Ag85B, protein-subunit promising candidate due to its high immunogenicity. However, hydrophobicity presents challenges manufacturing, expression, purification, Ag85B alone does not elicit sufficient immune stimulation. To overcome these limitations, this study aimed design temperature-responsive amine-terminated polylactic acid (PLA)-based nanosponge (aPNS) as both nanoadjuvant an efficient delivery carrier for Ag85B. Methods was produced using EZtag fusion tag vector, achieving product yield purity. It then loaded into aPNS, nanoparticle system with PLA core Pluronic shell, through process at 4 °C that preserved protein bioactivity. stability sustained-release profile Ag85B@aPNS were evaluated. In vitro cytotoxicity cellular uptake studies conducted macrophages. Protective immunogenicity assessed M. tuberculosis -challenged mice BCG-primed mice. Results successfully which exhibited good colloidal profile. Neither synthesized nor aPNS showed significant cytotoxicity. enhanced antigens by Compared BCG, demonstrated superior against improved Conclusion viable vaccination, showing potential standalone vaccine BCG-booster. Its ability enhance provide protection highlights promise addressing limitations current
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124529 - 124529
Published: July 30, 2024
Pancreatic cancer (PC) is one of the most lethal malignancies worldwide and its incidence increasing. Chemotherapy often associated to limited efficacy, poor targeting systemic toxicity. In this work, hydrophilic gemcitabine (GEM), widely used in PC treatment alone or combination, was conjugated with vitamin E succinate (VES) encapsulated Soluplus® micelles. This prodrug approach facilitated encapsulation anticancer drug into self-assembled copolymer Soluplus®/VES-GEM micelles were optimized regarding ratio components preparation process. The small-sized (<80 nm), monodisperse, highly stable, efficiently retaining conjugate showing significant antiproliferative activity against BxPC3 cell line. To improve biofunctionalization properties prepared micelles, biomimetic modification membrane further attempted by co-extruding (BxPC3) nanovesicles Several protocols prepare BxPC3-modified outcomes analyzed detail. Overall, results pave way innovative PC-targeted nanotherapies maximizing GEM hydrophobic compartments high stability affinity. also highlight need higher resolution techniques characterize coating nanocarriers bearing shells.
Language: Английский
Citations
3