Polymers,
Journal Year:
2023,
Volume and Issue:
15(6), P. 1438 - 1438
Published: March 14, 2023
A
significant
mechanical
properties
mismatch
between
natural
bone
and
the
material
forming
orthopedic
implant
device
can
lead
to
its
failure
due
inhomogeneous
loads
distribution,
resulting
in
less
dense
more
fragile
tissue
(known
as
stress
shielding
effect).
The
addition
of
nanofibrillated
cellulose
(NFC)
biocompatible
bioresorbable
poly(3-hydroxybutyrate)
(PHB)
is
proposed
order
tailor
PHB
different
types.
Specifically,
approach
offers
an
effective
strategy
develop
a
supporting
material,
suitable
for
regeneration,
where
stiffness,
strength,
hardness,
impact
resistance
be
tuned.
desired
homogeneous
blend
formation
fine-tuning
have
been
achieved
thanks
specific
design
synthesis
PHB/PEG
diblock
copolymer
that
able
compatibilize
two
compounds.
Moreover,
typical
high
hydrophobicity
significantly
reduced
when
NFC
added
presence
developed
copolymer,
thus
creating
potential
cue
growth.
Hence,
presented
outcomes
contribute
medical
community
development
by
translating
research
results
into
clinical
practice
designing
bio-based
materials
prosthetic
devices.
Biomacromolecules,
Journal Year:
2023,
Volume and Issue:
24(12), P. 5989 - 5997
Published: Nov. 14, 2023
Myocardial
infarction
(MI)
has
been
a
serious
threat
to
the
health
of
modern
people
for
long
time.
The
introduction
tissue
engineering
(TE)
therapy
into
treatment
MI
is
one
most
promising
therapeutic
schedules.
Considering
intrinsic
electrophysiological
activity
cardiac
tissue,
we
utilized
2,2,6,6-tetramethylpiperidinyl-1-oxyl
(TEMPO)-oxidized
cellulose
nanofibrils
(TOCNs)
with
excellent
biocompatibility
as
substrate,
and
sulfonated
carbon
nanotubes
(SCNTs)
remarkable
conductivity
water
dispersibility
electrically
active
material,
prepare
TOCN-SCNT
composite
hydrogels.
By
adjusting
content
SCNTs
from
0
5
wt
%,
hydrogels
exhibited
ranging
5.2
×
10
International Journal of Biological Macromolecules,
Journal Year:
2023,
Volume and Issue:
253, P. 126842 - 126842
Published: Sept. 11, 2023
Phosphorus-containing
polymers
have
received
much
attention
for
their
excellent
ability
to
regulate
bone
cell
differentiation
and
calcification.
Given
the
increasing
concern
about
environmental
issues,
it
is
promising
utilize
"green"
biomaterials
construct
novel
culture
scaffolds
tissue
engineering.
Herein,
surface-phosphorylated
cellulose
nanofibers
(P-CNFs)
were
fabricated
as
a
green
candidate
osteoblast
culture.
Compared
with
native
CNF,
P-CNFs
possessed
shorter
fiber
morphology
tunable
phosphate
group
content
(0-1.42
mmol/g).
The
zeta-potential
values
of
CNFs
enhanced
after
phosphorylation,
resulting
in
formation
uniform
stable
scaffolds.
behavior
mouse
(MC3T3-E1)
cells
showed
clear
content-dependent
proliferation.
adhered
well
proliferated
efficiently
on
P-CNF0.78
P-CNF1.05,
contents
0.78
1.05
mmol/g,
respectively,
whereas
grown
CNF
substrate
formed
aggregates
due
poor
attachment
exhibited
limited
In
addition,
P-CNF
substrates
optimal
provided
favorable
cellular
microenvironment
significantly
promoted
osteogenic
calcification,
even
absence
inducer.
bio-based
are
expected
mimic
components
provide
means
proliferation
