American Journal of Alzheimer s Disease & Other Dementias®,
Journal Year:
2023,
Volume and Issue:
38
Published: Oct. 1, 2023
Human
beings
have
always
pursued
a
prolonged
lifespan,
while
the
aging
of
nervous
system
is
associated
with
large
variety
diseases.
Pathological
results
in
series
neurodegenerative
diseases
and
can
cause
disability
death
elderly.
Therefore,
there
an
urgent
need
for
prevention
treatment
aging.
Chinese
herbal
medicines
long
history,
featuring
rich
safe
ingredients,
great
potential
development
anti-aging
treatment.
We
searched
publications
on
PubMed
key
words
“anti-aging
system”
“Chinese
medicine”
recent
10
years,
found
sixteen
medicines.
Then
by
comparing
their
popularity
use
as
well
active
components
based
research
articles,
five
common
namely
Ginseng
Radix,
Lycii
Fructus,
Astragali
Coptidis
Rhizoma
Ginkgo
Folium,
were
confirmed
to
be
most
related
anti-nervous
neural
degenerative
At
same
time,
models,
action
mechanisms
curative
effects
these
reviewed.
From
reviewed
this
paper,
many
encouraging
treating
revealed
more
potent
herbs
would
explored
help
proposed
possible
mechanisms.
Briefings in Bioinformatics,
Journal Year:
2024,
Volume and Issue:
25(2)
Published: Jan. 22, 2024
Abstract
Herbs
applicability
in
disease
treatment
has
been
verified
through
experiences
over
thousands
of
years.
The
understanding
herb–disease
associations
(HDAs)
is
yet
far
from
complete
due
to
the
complicated
mechanism
inherent
multi-target
and
multi-component
(MTMC)
botanical
therapeutics.
Most
existing
prediction
models
fail
incorporate
MTMC
mechanism.
To
overcome
this
problem,
we
propose
a
novel
dual-channel
hypergraph
convolutional
network,
namely
HGHDA,
for
HDA
prediction.
Technically,
HGHDA
first
adopts
an
autoencoder
project
components
target
protein
onto
low-dimensional
latent
space
so
as
obtain
their
embeddings
by
preserving
similarity
characteristics
original
feature
spaces.
model
high-order
relations
between
herbs
components,
design
channel
encode
that
describes
patterns
herb-component
via
convolution.
other
also
established
same
way
diseases
proteins.
drugs
are
then
aggregated
our
network
results
with
scoring
function.
evaluate
performance
series
extensive
experiments
have
conducted
on
two
benchmark
datasets,
demonstrate
superiority
state-of-the-art
algorithms
proposed
Besides,
case
study
Chuan
Xiong
Astragalus
membranaceus
strong
indicator
verify
effectiveness
seven
eight
out
top
10
predicted
Chuan-Xiong
Astragalus-membranaceus,
respectively,
reported
literature.
Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Aug. 30, 2024
Astragali
radix
(AR,
namded
Huangqi
in
Chinese)
is
the
dried
root
of
Astragalus
membranaceus
(Fisch.)
Bge.
var.
mongholicus
(Bge.)
Hsiao
or
As
a
widely
used
ethnomedicine,
biological
activities
AR
include
immunomodulatory,
anti-hyperglycemic,
anti-oxidant,
anti-aging,
anti-inflammatory,
anti-viral,
anti-tumor,
cardioprotective,
and
anti-diabetic
effects,
with
minimum
side
effects.
Currently,
it
known
that
polysaccharides,
saponins,
flavonoids
are
indispensable
components
AR.
In
this
review,
we
will
elaborate
research
advancements
on
ethnobotany,
ethnopharmacological
practices,
phytochemicals,
pharmacological
activities,
clinical
uses,
quality
control,
production
developments,
toxicology.
The
information
expected
to
assist
clinicians
scientists
developing
useful
therapeutic
medicines
minimal
systemic
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 2, 2024
widely
used
in
traditional
Chinese
medicine,
exhibits
multiple
pharmacological
effects,
including
immune
stimulation,
antioxidation,
hepatoprotection,
diuresis,
antidiabetes,
anticancer,
and
expectorant
properties.
Its
main
bioactive
compounds
include
flavonoids,
triterpene
saponins,
polysaccharides.
Astragalus
polysaccharides
(APS),
one
of
its
primary
components,
have
been
shown
to
possess
a
variety
activities,
such
as
antioxidant,
immunomodulatory,
anti-inflammatory,
antitumor,
antidiabetic,
antiviral,
hepatoprotective,
anti-atherosclerotic,
hematopoietic,
neuroprotective
effects.
This
review
provides
comprehensive
summary
the
molecular
mechanisms
therapeutic
effects
APS
treating
neurodegenerative
diseases,
Alzheimer's
disease
(AD),
Parkinson's
(PD),
sclerosis
(MS).
It
discusses
how
improve
insulin
resistance,
reduce
blood
glucose
levels,
enhance
cognitive
function,
Aβ
accumulation
neuronal
apoptosis
by
modulating
various
pathways
Nrf2,
JAK/STAT,
Toll,
IMD.
For
PD,
protect
neurons
stabilize
mitochondrial
function
inhibiting
ROS
production
promoting
autophagy
through
PI3K/AKT/mTOR
pathway.
also
oxidative
stress
neurotoxicity
induced
6-hydroxydopamine,
showcasing
their
In
MS,
alleviate
symptoms
suppressing
T
cell
proliferation
reducing
pro-inflammatory
cytokine
expression
via
PD-1/PD-Ls
promote
myelin
regeneration
activating
Sonic
hedgehog
signaling
pathway
fostering
differentiation
neural
stem
cells
into
oligodendrocytes.
article
emphasizes
significant
activities
APS,
highlighting
potential
promising
candidates
for
treatment
diseases.
The FASEB Journal,
Journal Year:
2024,
Volume and Issue:
38(13)
Published: June 15, 2024
Abstract
Oxidative
stress
is
proposed
as
a
regulatory
element
in
various
neurological
disorders,
which
involved
the
progress
of
several
neurodegenerative
diseases
such
Alzheimer's
disease
(AD)
and
Parkinson's
(PD).
Antioxidant
drugs
are
widely
used
to
alleviate
disorders.
Astragalus
membranaceus
(Huangqi,
AM)
commonly
medicinal
herb
with
wide
range
pharmacological
effects.
Here,
protective
effect
mechanism
AM
extract
(AME)
its
bioactive
compounds
against
disorders
via
alleviating
oxidative
were
detected
using
adult
Drosophila
melanogaster
.
The
drug
safety
was
measured
by
development
analysis;
resistance
ability
survival
rate
under
H
2
O
environment;
ROS
level
DHE
staining
gstD1‐GFP
fluoresence
assay;
antioxidative
abilitiy
represent
measuring
antioxidant
enzyme
activity,
antioxidative‐related
gene
expression,
ATP
MFN2
levels.
neuroprotective
evaluated
lifespan
locomotion
analysis
Aβ42
transgenic
Pink1
B9
mutants.
AME
dramatically
increased
rates,
improved
CAT
restored
decreased
mRNA
expressions
Sod1,
Cat
,
CncC
stimulation,
ameliorated
neurobehavioral
defects
AD
PD.
Thirteen
small
molecules
had
function,
vanillic
acid
daidzein
most
potent
effect.
Vanillic
could
increase
activities
SOD
CAT,
GSH
level,
genes.
improve
levels
MFN2,
ND42
SDHC
rescue
mitochondrial
dysfunction.
Furthermore,
Daidzein
defect
Aβ‐induced
mode.
Taken
together,
plays
role
damage,
thereby
potential
natural
treat
CytoJournal,
Journal Year:
2025,
Volume and Issue:
22, P. 2 - 2
Published: Jan. 7, 2025
Microglial
activation
is
a
hallmark
of
pathogenic
retinal
conditions
such
as
ischemia-reperfusion
(RIR).
While
sortilin-related
vacuolar
protein
sorting
10
domain
containing
receptor
2
(Sorcs2)
and
laminin
subunit
alpha
1
(Lama1)
have
been
implicated
in
neuroinflammatory
processes,
their
roles
regulating
microglial
RIR
are
not
reported.
The
current
work
studied
the
potential
Sorcs2
Lama1
negative
regulators
assessed
therapeutic
Astragalus
polysaccharide
(AP).
Transcriptome
profiling
was
conducted
specimens
group
72
h
after
induction.
Oxygen-glucose
deprivation/reperfusion
(OGD/R)
rat
cells
employed
cellular
induction
model
RIR.
functional
role
dictating
investigated
vitro
vivo
using
lentivirus-based
gene
expression.
Further,
effect
AP
on
RIR-mediated
investigated.
were
identified
two
downregulated
genes
samples
following
OGD/R
triggered
pro-inflammatory
induced
downregulation
Lama1.
or
overexpression
hindered
OGD/R-induced
attenuated
inflammatory
expansion
microglia
RIR-induced
samples.
treatment
able
to
neutralize
oxidative
stress,
promote
expression
Lama1,
suppress
activation.
Our
findings
pinpoint
could
be
an
antioxidant
attenuate
ameliorate
damages
Journal of Inflammation Research,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 3485 - 3498
Published: March 1, 2025
Background:
Sleep
is
vital
for
maintaining
the
health
of
organism.
Chronic
sleep
deprivation
(CSD)
a
key
contributor
to
significant
risks,
including
induction
gastrointestinal
disorders.
However,
mechanism
CSD
caused
intestinal
damage
remains
unclear.
Methods:
Drosophila
melanogaster
as
an
in
vivo
model
was
used
investigate
CSD-induced
injury,
well
ameliorative
effect
caffeic
acid.
Results:
resulted
reduced
survival
and
severely
affected
homeostasis
flies,
evidenced
by
disruption
acid-base
homeostasis,
increased
feeding,
permeability
shortened
length.
Meanwhile,
expressions
immune
deficiency
(IMD)
pathway-related
genes
PGRP-SB1,
Dpt,
AttA,
AttB
Mtk
were
significantly
up-regulated
intestine
flies.
On
other
hand,
Caffeic
acid
supplementation
restored
intake,
while
improving
barrier
length,
effectively
reducing
damage.
In
addition,
administration
decreased
AttA
flies
gut.
Discussion:
These
results
suggested
that
could
disrupt
gut
adult
overactivating
IMD
pathway,
has
obvious
protective
role
on
homeostasis.
Keywords:
thermogenetic
CSD,
intestine,
Immune
signaling,
polyphenolic
compounds,
