Selection and identification of DNA aptamer binding VDAC1 for tumor tissue imaging and targeted drug delivery DOI
Kai Zhang, Baoyin Yuan,

Xiaoshuo Dai

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141249 - 141249

Published: Feb. 1, 2025

Language: Английский

Different Targeting Ligands-Mediated Drug Delivery Systems for Tumor Therapy DOI Creative Commons
Shuxin Yan,

Jintong Na,

Xiyu Liu

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 248 - 248

Published: Feb. 7, 2024

Traditional tumor treatments have the drawback of harming both cells and normal cells, leading to significant systemic toxic side effects. As a result, there is pressing need for targeted drug delivery methods that can specifically target or tissues. Currently, researchers made progress in developing systems therapy using various targeting ligands. This review aims summarize recent advancements therapy, focusing on different ligands such as folic acid, carbohydrates, peptides, aptamers, antibodies. The also discusses advantages, challenges, future prospects these systems.

Language: Английский

Citations

41
Aptamers as an approach to targeted cancer therapy DOI Creative Commons
Fatemeh Mahmoudian,

Azin Ahmari,

Shiva Shabani

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 16, 2024

Abstract Conventional cancer treatments can cause serious side effects because they are not specific to cells and damage healthy cells. Aptamers often single-stranded oligonucleotides arranged in a unique architecture, allowing them bind specifically target sites. This feature makes an ideal choice for targeted therapeutics. They typically produced through the systematic evolution of ligands by exponential enrichment (SELEX) undergo extensive pharmacological revision modify their affinity, specificity, therapeutic half-life. act as drugs themselves, directly inhibiting tumor Alternatively, be used drug delivery systems transport cells, minimizing toxicity In this review, we will discuss latest most advanced approaches using aptamers treatment, particularly therapy overcoming resistance conventional therapies.

Language: Английский

Citations

34
Advances in Mesoporous Silica Nanoparticles as Carriers for Drug Delivery and other Biomedical Applications DOI

Grini Mohammed Ilyes,

Benbayer Chahinez,

Salima Saïdi‐Besbes

et al.

Microporous and Mesoporous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 113603 - 113603

Published: March 1, 2025

Language: Английский

Citations

3
Engineered Liposomes in Interventional Theranostics of Solid Tumors DOI
Nagavendra Kommineni,

Ruchita Chaudhari,

João Conde

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(8), P. 4527 - 4557

Published: July 14, 2023

Engineered liposomal nanoparticles have unique characteristics as cargo carriers in cancer care and therapeutics. Liposomal theranostics shown significant progress preclinical clinical models the past few years. hybrid systems not only been approved by FDA but also reached market level. Nanosized liposomes are clinically proven for delivering multiple therapeutic well imaging agents to target sites (i) of solid tumors, (ii) image-guided therapeutics, (iii) combination applications. The choice diagnostics therapeutics can intervene property engineered system. However, integrating probes within lipid self-assembly "liposome" may compromise their overall performance. On other hand, suffer from fragile nature, site-selective tumor targeting, specific biodistribution premature leakage loaded molecules before reaching site. Various engineering approaches, viz., grafting, conjugation, encapsulations, etc., investigated overcome aforementioned issues. It has studied that surface-engineered demonstrate better selectivity improved activity retention cells/or tumors. should be noted several parameters like reproducibility, stability, smooth circulation, toxicity vital organs, patient compliance, etc. must addressed using tumors or models. Herein, we reviewed importance challenges medicines targeted with a translational overview.

Language: Английский

Citations

29
Targeting the Ubiquitin–Proteasome System and Recent Advances in Cancer Therapy DOI Creative Commons
Daniela Spano, Giuliana Catara

Cells, Journal Year: 2023, Volume and Issue: 13(1), P. 29 - 29

Published: Dec. 22, 2023

Ubiquitination is a reversible post-translational modification based on the chemical addition of ubiquitin to proteins with regulatory effects various signaling pathways. can alter molecular functions tagged substrates respect protein turnover, biological activity, subcellular localization or protein–protein interaction. As result, wide variety cellular processes are under ubiquitination-mediated control, contributing maintenance homeostasis. It follows that dysregulation ubiquitination reactions plays relevant role in pathogenic states human diseases such as neurodegenerative diseases, immune-related pathologies and cancer. In recent decades, enzymes ubiquitin–proteasome system (UPS), including E3 ligases deubiquitinases (DUBs), have attracted attention novel druggable targets for development new anticancer therapeutic approaches. This perspective article summarizes peculiarities shared by involved reaction which, when deregulated, lead tumorigenesis. Accordingly, an overview main pharmacological interventions targeting UPS clinical use still trials provided, also highlighting limitations efficacy these Therefore, attempts circumvent drug resistance side well UPS-related emerging technologies therapeutics discussed.

Language: Английский

Citations

29
Imaging-guided precision hyperthermia with magnetic nanoparticles DOI
Ali Shakeri‐Zadeh, Jeff W. M. Bulte

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: 3(3), P. 245 - 260

Published: Nov. 7, 2024

Language: Английский

Citations

11
In vitro and in silico investigation of glycyrrhizic acid encapsulated zein nanoparticles: A synergistic targeted drug delivery approach for breast cancer DOI
Amit Kumar Srivastav, Pradeep Kumar Rajput, Jyoti Jaiswal

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131368 - 131368

Published: April 3, 2024

Language: Английский

Citations

9
Aptamer-conjugated liposome system for targeting MUC1-positive cancer: an in silico screening approach DOI Creative Commons

Md Shakil Ahmed Khan,

Jiwoo Park,

Somin Lee

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 1(1)

Published: Jan. 28, 2025

Language: Английский

Citations

1
The recent blooming of therapeutic aptamers DOI Creative Commons
Valeriana Cesarini, Silvia Lucia Appleton, Vittorio de Franciscis

et al.

Molecular Aspects of Medicine, Journal Year: 2025, Volume and Issue: 102, P. 101350 - 101350

Published: Feb. 10, 2025

Language: Английский

Citations

1
Screening and Diagnosis of Colorectal Cancer Using Nucleic Acid Aptamers Targeting Solobacterium moorei: Development of Electrochemical Sensors for Clinical Application DOI

Decai Yuan,

Cheng Qiu, Hui Chen

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137669 - 137669

Published: March 1, 2025

Language: Английский

Citations

1