Innovative nanocarrier systems for enhanced delivery of phyto-active compounds in cancer therapy DOI
Khusbu Dwivedi, Ankit Sahoo, Waleed Hassan Almalki

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 26

Published: Dec. 20, 2024

Millions of people worldwide suffer from cancer, facing challenges such as treatments affecting healthy cells, suboptimal responses, adverse effects, recurrence risk, drug resistance, and nonspecific targeting. Chemoresistance leads to fatalities, but phytoactives show promise in cancer management despite limitations high metabolism, poor absorption, dosage requirements. Challenges the large-scale isolation phytoactive compounds, solubility, bioavailability, targeting limit their development. Recent developments, including carbohydrate, lipid, protein-based nanoparticles, have enhanced treatment by improving bioavailability targeted delivery polyphenols, alkaloids, sulfur-containing flavonoids, terpenes. Despite advancements, clinical application faces hurdles inconsistent immune responses. This article discusses phytoactive-loaded nanoformulations management, highlighting delivery, unmet needs, challenges. Further research is needed overcome these fully understand potential management.

Language: Английский

Recent progress in zein nanoparticles: A promising approach for advancing cancer therapy DOI
Mohammad Sameer Khan, Mahak Fatima, Garima Gupta

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 97, P. 105770 - 105770

Published: May 11, 2024

Language: Английский

Citations

23
Nanoscale strides: exploring innovative therapies for breast cancer treatment DOI Creative Commons
Sruthi Laakshmi Mugundhan, M. Mothilal

RSC Advances, Journal Year: 2024, Volume and Issue: 14(20), P. 14017 - 14040

Published: Jan. 1, 2024

Nanotechnology revolutionizes breast cancer treatment by improving drug delivery, overcoming barriers, and reducing side effects. This review highlights its potential superiority over conventional methods, transforming management.

Language: Английский

Citations

13
In silico and in vitro profiling of sphingomyelin loaded zein nanoconstructs with optimized aromatic interactions and pharmacokinetics for colon cancer therapeutics DOI
Amit Kumar Srivastav, Jyoti Jaiswal, Pradeep Kumar Rajput

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141845 - 141845

Published: March 1, 2025

Language: Английский

Citations

0
Saponins as Natural Emulsifiers: Challenges, Regulatory Landscape, and Future in Biomedical and Cosmetic Fields DOI
Eliana Díaz-Cruces,

Thara Tom,

Vicente M. Gómez‐López

et al.

Industrial & Engineering Chemistry Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Language: Английский

Citations

0
Exploring the effects of paclitaxel-loaded zein nanoparticles on human ovarian carcinoma cells DOI Creative Commons
Stefania Scicchitano, Agnese Gagliardi, Nicola Ambrosio

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 27, 2025

The development of innovative antitumor formulations that are able to increase the mortality cancer cells while decreasing efficacious pharmacological dosage is a fundamental goal modern oncological research. In this study paclitaxel (PTX)-nanomedicine was tested on two lines human high-grade serous ovarian carcinoma (hHGS-OC). Zein, vegetal protein, employed obtain nanoparticles containing lipophilic compound (NanoPTX) characterized by mean diameter 160 nm, narrow size distribution, negative zeta potential and prolonged release drug over time. NanoPTX HEY COV362 demonstrating an apoptosis, particularly papillary cystadenocarcinoma (55.2% p value 0.037 for vs 70.25%, 0.08 PTX) with respect free form drug. fluorescent nanosystems were significant cell uptake after few hours incubation they promoted reduction in intracellular reactive oxygen species. results need be validated different hHGS-OC real efficacy proposed nanomedicine needs investigated using vivo models carcinoma.

Language: Английский

Citations

0
Targeted delivery of neratinib/xanthan gum-capped calcium carbonate nanoparticles induces apoptosis through PI3K/AKT pathway in breast cancer mice model DOI
Yilin Wu, Yanxi Liu, Yawen Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142963 - 142963

Published: April 1, 2025

Language: Английский

Citations

0
The roles of flaxseed gum and its oligosaccharides as stabilizers in zein nanoparticles for apigenin delivery: Stability, antioxidant activity, bioavailability, molecular simulations DOI
Yufei Liu, Ziliang Li, Shuaijun Lu

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: 484, P. 144439 - 144439

Published: April 21, 2025

Language: Английский

Citations

0
Research progress on the nano-delivery systems of food-derived bioactive components DOI
Yahong Han,

Yaqiong Pei,

Juyuan Wang

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105189 - 105189

Published: Sept. 1, 2024

Language: Английский

Citations

1
Innovative nanocarrier systems for enhanced delivery of phyto-active compounds in cancer therapy DOI
Khusbu Dwivedi, Ankit Sahoo, Waleed Hassan Almalki

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 26

Published: Dec. 20, 2024

Millions of people worldwide suffer from cancer, facing challenges such as treatments affecting healthy cells, suboptimal responses, adverse effects, recurrence risk, drug resistance, and nonspecific targeting. Chemoresistance leads to fatalities, but phytoactives show promise in cancer management despite limitations high metabolism, poor absorption, dosage requirements. Challenges the large-scale isolation phytoactive compounds, solubility, bioavailability, targeting limit their development. Recent developments, including carbohydrate, lipid, protein-based nanoparticles, have enhanced treatment by improving bioavailability targeted delivery polyphenols, alkaloids, sulfur-containing flavonoids, terpenes. Despite advancements, clinical application faces hurdles inconsistent immune responses. This article discusses phytoactive-loaded nanoformulations management, highlighting delivery, unmet needs, challenges. Further research is needed overcome these fully understand potential management.

Language: Английский

Citations

1