International Journal for Parasitology Drugs and Drug Resistance,
Journal Year:
2024,
Volume and Issue:
27, P. 100573 - 100573
Published: Dec. 12, 2024
Giardiasis,
caused
by
Giardia
duodenalis,
is
a
prevalent
and
significant
zoonotic
disease.
While
nitroimidazole
drugs
are
primarily
used
to
treat
giardiasis,
the
urgent
need
for
development
formulation
of
new
has
arisen
due
increasing
drug
resistance.
Several
plant
derived
medicine
have
been
employed
as
antiparasitic
drugs.
This
study
evaluated
anti-Giardia
effect
Licochalcone
A
(Lic
A)
through
both
in
vitro
vivo
experiments.
We
determined
50%
inhibitory
concentration
(IC
Molecules,
Journal Year:
2023,
Volume and Issue:
28(16), P. 6081 - 6081
Published: Aug. 16, 2023
In
order
to
obtain
homogeneous
Sanghuangporus
vaninii
polysaccharides
with
antioxidant
and
anti-inflammatory
activities,
a
response
surface
method
(RSM)
was
used
compare
the
polysaccharide
extraction
rate
of
hot
water
ultrasonic-assisted
from
vaninii.
The
optimal
conditions
for
were
determined
as
follows:
an
temperature
60
°C,
time
min,
solid-liquid
ratio
40
g/mL,
ultrasonic
power
70
W.
An
SVP
(Sanghuangporus
polysaccharides)
1.41%
achieved.
Five
monosaccharides
obtained
by
gradient
ethanol
precipitation
diethylaminoethyl-cellulose
(DEAE)
SephadexG-100
separation
purification.
five
characterized
high
performance
liquid
chromatography,
ultraviolet
spectrum,
Fourier
transform
infrared
TG
(thermogravimetric
analysis),
Zeta
potential,
SEM
(scanning
electron
microscopy).
had
certain
levels
activity
in
vitro.
addition,
we
investigated
effects
derived
on
lipopolysaccharide
(LPS)-induced
RAW
264.7
cells
Kupffer
cells.
Further,
found
that
SVP-60
significantly
inhibited
pro-inflammatory
cytokines,
such
interleukin
(IL)-1β,
IL-6,
tumor
necrosis
factor
(TNF)-α
promoted
level
cytokine
IL-10
Our
study
provides
theoretical
support
potential
application
field
activities
Acupuncture and Herbal Medicine,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 29, 2024
Licorice,
a
perennial
herb
of
Leguminosa,
is
one
the
oldest
and
most
widely
used
herbal
medicines
worldwide.
Its
distinct
sweet
flavor
rich
medicinal
value
make
it
an
integral
component
traditional
Chinese
medicine
(TCM)
formulations,
which
continue
to
be
employed.
The
main
chemical
constituents
licorice
include
triterpenoid
saponins,
flavonoids,
polysaccharides.
Experimental
clinical
studies
have
demonstrated
that
various
extracts
pure
compounds
derived
from
exhibit
wide
range
pharmacological
properties
including
anti-inflammatory,
antioxidant,
antimicrobial,
antiviral,
antitumor,
immune-regulatory,
neuroprotective
activities.
bioactive
offer
therapeutic
benefits
for
cardiovascular
cerebrovascular
diseases,
diabetes
mellitus,
liver
disorders.
This
comprehensive
review
discusses
primary
their
activities,
describes
in
vivo
vitro
models
employed
studying
licorice,
its
potential
targets
mechanisms
action.
Furthermore,
we
discuss
toxicological
profile,
side
effects,
dosage
recommendations,
applications
licorice.
aims
establish
foundation
further
research
on
safe
effective
utilization
while
facilitating
in-depth
exploration
fostering
development
novel
agents.
Graphical
abstract:
http://links.lww.com/AHM/A102
Foods,
Journal Year:
2025,
Volume and Issue:
14(5), P. 874 - 874
Published: March 4, 2025
Glycyrrhiza
uralensis
Fisch.
is
a
medicinal
herb
that
can
be
added
to
food
provide
therapeutic
effects
and
reduce
the
burden
of
medications.
Herein,
immunomodulatory
polysaccharides
(GPs)
were
verified
illustrated
by
intervening
immunocompromised
rats
treated
with
different
doses
GPs,
which
reflected
for
adjusting
composition
structure
intestinal
microbiota
altering
metabolic
profile.
The
GPs
exerted
regulating
microenvironment.
In
particular,
could
promote
growth
probiotic
bacteria
Allobaculum,
norank__o_Clostridia_UCG-014,
Dubosiella,
g__norank_o___RF39
curb
harmful
Enterococcus.
results
showed
had
prebiotic
effect,
contributed
improving
environment
maintaining
health.
addition,
content
beneficial
differential
metabolites
was
up-regulated,
especially
short-chain
fatty
acids,
alanine,
aspartate,
glutamate
metabolism;
arginine
biosynthesis;
glyoxylate
dicarboxylate
metabolism
being
most
enriched
pathways.
These
pathways
imply
process
effector
it
are
focused.
Overall,
purpose
this
article
lies
in
providing
support
application
immune
function.
