The regulatory effect of polysaccharides on the gut microbiota and their effect on human health: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132170 - 132170

Published: May 9, 2024

Language: Английский

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Polysaccharides in fruits: Biological activities, structures, and structure-activity relationships and influencing factors-A review

Food Chemistry, Journal Year: 2024, Volume and Issue: 451, P. 139408 - 139408

Published: April 23, 2024

Language: Английский

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Colon‐Targeted Ginseng Polysaccharides‐Based Microspheres for Improving Ulcerative Colitis via Anti‐Inflammation and Gut Microbiota Modulation

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Natural plant‐derived polysaccharides exhibit substantial potential for treating ulcerative colitis (UC) owing to their anti‐inflammatory and antioxidant properties favorable safety profiles. However, practical application faces several challenges, including structural instability in gastric acid, imprecise targeting of inflamed regions, limited intestinal retention times. To address these limitations, pH‐responsive, colon‐targeting microspheres (pWGPAC MSs) are developed delivering phosphorylated wild ginseng (pWGP) alleviate UC. These pWGPAC MSs fabricated by incorporating pWGP into calcium‐crosslinked alginate with subsequent chitosan surface modification enhance mucosal adhesion. demonstrated exceptional stability under acidic conditions while enabling targeted release the colon. In a mouse model UC, effectively mitigated injury, attenuated inflammation, restored barrier function. Further mechanistic investigations revealed that modulated TLR4/MYD88 signaling pathway promoted M2 macrophage polarization. Integrated microbiome metabolome analyses regulated gut microbiota composition decreased pro‐inflammatory metabolite levels. addition, promising Collectively, findings establish as therapeutic strategy treatment UC provide solid foundation future clinical applications.

Language: Английский

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Low molecular weight polysaccharide of Tremella fuciformis exhibits stronger antioxidant and immunomodulatory activities than high molecular weight polysaccharide

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136097 - 136097

Published: Sept. 1, 2024

Language: Английский

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Elucidation of antioxidant activities of intracellular and extracellular polysaccharides from Cordyceps militaris in vitro and their protective effects on ulcerative colitis in vivo

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131385 - 131385

Published: April 4, 2024

Language: Английский

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Investigating the Alleviating Effect of Fucoidan from Apostichopus japonicus on Ulcerative Colitis by Mice Experiments and In Vitro Simulation of Human Fecal Fermentation

Foods, Journal Year: 2025, Volume and Issue: 14(4), P. 574 - 574

Published: Feb. 9, 2025

Fucoidan from Apostichopus japonicus (Aj-FUC) is a marine polysaccharide extracted the high-quality sea cucumber, which has received increasing attention for its multiple biological activities. In this study, Aj-FUC was extracted, and basic structure characterized, while alleviating efficacy of on ulcerative colitis (UC) investigated using C57BL/6 mice. The improvement fecal gut microbiota in healthy individuals inflammatory bowel disease (IBD) patients explored vitro simulated fermentation. results reflected that treatment attenuated histopathological damage associated with colitis, reduced levels IL-6, IL-1β, TNF-α. also upregulated expression ZO-1 occludin, thereby aiding repair intestinal barrier. Furthermore, enhanced short-chain fatty acids (SCFAs) helped restore balance microbiota, particularly by relative abundance Akkermansia. simulation fermentation showed could modulate IBD increase beneficial bacteria. conclusion, study highlights can alleviate UC modulating factors, improving barrier, regulating flora variety ways.

Language: Английский

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Polygonatum cyrtonema Hua polysaccharide alleviates ulcerative colitis via gut microbiota-independent modulation of inflammatory immune response

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 356, P. 123387 - 123387

Published: Feb. 16, 2025

Language: Английский

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Stimulus-responsive polysaccharide-based hydrogels: From design to biomedical applications

Precision medicine and engineering., Journal Year: 2024, Volume and Issue: 1(1), P. 100001 - 100001

Published: July 28, 2024

Stimulus-responsive hydrogels can undergo controllable shape deformation and exhibit sol-gel transition behavior under stimulus signals such as pH, reactive oxygen species (ROS), heat, light. Polysaccharides have become ideal candidates for constructing stimulus-responsive due to their biocompatibility biodegradability. The diversity of molecular weights functional groups polysaccharides allows them self-assemble or cooperate with other materials obtain through physical chemical crosslinking. Bioactive ingredients nanomaterials be conveniently encapsulated in the hydrogel matrix meet various requirements. polysaccharide-based are widely used biomedical field, especially fields drug delivery, tissue engineering, biosensors, imaging. In this review, design strategies recent research advances stimuli-responsive summarized. Future challenges also presented, review will guide study polysaccharide hydrogels.

Language: Английский

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Progress in the metabolic kinetics and health benefits of functional polysaccharides from plants, animals and microbes: A review

Carbohydrate Polymer Technologies and Applications, Journal Year: 2024, Volume and Issue: 7, P. 100526 - 100526

Published: June 1, 2024

Functional polysaccharides are characterized by functional and structural biomolecules, which play a dual role, both as nutrient molecules providing energy signalling involved in intercellular communications. There increasing evidences showing that possess beneficial effects for treating chronic diseases, such cancer, cardiovascular disease, etc, but its mechanism of action remains imprecision. Additionally, due to the limitations precision detection methods complexity their structures, metabolic kinetics behaviours or bioavailability polysaccharides, interaction between it entering systemic circulation target cells have been conundrum faced researcher. This review summarized latest advances efficacy diseases structure-activity relationship, absorption behaviours, specific cellular receptors so understand mechanisms bioactivities. is expected provide new insights paves way application.

Language: Английский

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Structural characterization and anti-inflammatory activity of a novel polysaccharide from Paeonia lactiflora Pall

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 120, P. 106392 - 106392

Published: Aug. 9, 2024

A novel homogeneous polysaccharide, designated as PLPN-2, was screened from the dried root of Paeonia lactiflora Pall. using an activity-oriented approach, demonstrating remarkable anti-inflammatory properties. Structural analysis revealed that PLPN-2 is α-glucan comprising α-(1 → 4)-glucan backbone with α-Glcp-(1→/α-Glcp-(1 6)-β-Glcp-(1→ linked to at C-6. exhibited efficacy in alleviating inflammatory symptoms associated DSS-induced colitis mice and inhibiting release pro-inflammatory elements including IL-6, TNF-α, IL-1β RAW264.7 macrophages promoted by LPS. Moreover, demonstrated ability impede nuclear translocation p65 protein reduce phosphorylation levels JNK, ERK1/2, p38, p65, IκBα. The findings suggest exhibits potential agent through inhibition MAPK NF-κB signaling pathways. Therefore, shows promising prospects a functional for relieving inflammation-related disorders.

Language: Английский

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