A review of polysaccharides from Ganoderma lucidum: Preparation methods, structural characteristics, bioactivities, structure-activity relationships and potential applications

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140645 - 140645

Published: Feb. 1, 2025

Language: Английский

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Role and Therapeutic Targeting Strategies of Neutrophil Extracellular Traps in Inflammation

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 5265 - 5287

Published: Sept. 1, 2023

Abstract: Neutrophil extracellular traps (NETs) are large DNA reticular structures secreted by neutrophils and decorated with histones antimicrobial proteins. As a key mechanism for to resist microbial invasion, NETs play an important role in the killing of microorganisms (bacteria, fungi, viruses). Although mostly known mediating killing, increasing evidence suggests that excessive induced stimulation physical chemical components, microorganisms, pathological factors can exacerbate inflammation organ damage. This review summarizes induction focuses on strategies inhibiting NETosis mechanisms involved pathogen evasion NETs. Furthermore, herbal medicine inhibitors nanodelivery improve efficiency inhibition levels Graphical Keywords: neutrophil traps, inflammation, targeted inhibition, nanotherapy,

Language: Английский

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Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 22, 2024

Hepatocellular carcinoma (HCC) is a prevalent malignancy, often associated with compromised immune function in affected patients. This can be attributed to the secretion of specific factors by liver cancer cells, which hinder response and lead state suppression. Polysaccharides derived from traditional Chinese medicine (TCM) are valuable constituents known for their immunomodulatory properties. review aims look into effects TCM polysaccharides on HCC. The primarily manifested through activation effector T lymphocytes, dendritic NK macrophages against hepatocellular both vivo vitro settings. Furthermore, have demonstrated remarkable adjuvant antitumor HCC clinical Therefore, utilization holds promising potential development novel therapeutic agents or adjuvants advantageous properties

Language: Английский

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Structure, sources, functional mechanisms, and applications of bioactive glycopeptides in food: a comprehensive review

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: 157, P. 104899 - 104899

Published: Feb. 1, 2025

Language: Английский

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Research progress on structural characterization and bioactivities of Poria cocos and Ganoderma polysaccharides

Food & medicine homology., Journal Year: 2024, Volume and Issue: 2(1), P. 9420040 - 9420040

Published: Sept. 18, 2024

Language: Английский

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Ganoderma lucidum Polysaccharide Peptide Alleviates Cyclophosphamide-Induced Male Reproductive Injury by Reducing Oxidative Stress and Apoptosis

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1632 - 1632

Published: July 23, 2024

Chemotherapy is an important factor leading to male infertility. It crucial discover safe and effective treatments prevent reproductive injury caused by chemotherapy. The

Language: Английский

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Size exclusion chromatography and asymmetrical flow field-flow fractionation for structural characterization of polysaccharides: A comparative review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134236 - 134236

Published: July 29, 2024

Language: Английский

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Identification and Characterization of Genes Associated with Intestinal Ischemia-Reperfusion Injury and Oxidative Stress: A Bioinformatics and Experimental Approach Integrating High-Throughput Sequencing, Machine Learning, and Validation

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 701 - 722

Published: Jan. 1, 2025

Intestinal ischemia-reperfusion injury (IIRI) occurs as a result of temporary blood flow interruption, leading to tissue damage upon reperfusion. Oxidative stress plays critical role in this process, instigating inflammation and cell death. Identifying characterizing genes associated with the oxidative response can offer valuable insights into potential therapeutic targets for managing IIRI. The IIRI dataset was sourced from NCBI Gene Expression Omnibus Database (GEO), while were obtained Genecards database. Following acquisition differentially expressed IIRI, they cross-linked yield related (IOSRGs). least absolute shrinkage selection operator, well support vector machine random forest algorithm, utilized learning. Subsequently, PPI network established, Degree MNC algorithms Cytohuba plugin integrated through learning identify hub IOSRGs (HIOSRGs). A mouse model ROC curve employed verify accuracy HIOSRGs. Finally, siRNA suppress expression HDAC3 Caco2 cells, changes levels before after hypoxia-reoxygenation cells observed. total 277 OSRGs 4 HIOSRGs obtained. Concurrently, vivo experimental results C57BL/6 mice, establishment curves, reflected specificity knockdown resulted increased hypoxia-reoxygenation, underscoring significant This study elucidates interplay between offering novel pathogenesis medical interventions

Language: Английский

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Ganoderma Lucidum Polysaccharides: A Comprehensive Overview of Pharmacological Effects and Future Perspectives

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105990 - 105990

Published: Jan. 1, 2025

Language: Английский

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A review of pharmacological mechanisms, challenges and prospects of macromolecular glycopeptides

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140294 - 140294

Published: Jan. 1, 2025

Language: Английский

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