Prospective Application of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Disseminated Intravascular Coagulation DOI Creative Commons

Chengran Wang,

Xiaoqing Zhao, Keyan Wang

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 11957 - 11971

Published: Nov. 1, 2024

Disseminated intravascular coagulation (DIC) is an acquired disorder characterized by systemic activation of blood coagulation, which can arise from various causes. Owing to its abrupt onset, rapid progression, and high mortality rate, DIC presents a major clinical challenge. Anticoagulant drugs, such as heparin or low-molecular-weight heparin, are the current gold standard treatment; however, these interventions pose considerable bleeding risks. Thus, safer more effective therapeutic strategies urgently required. their strong anti-inflammatory tissue repair capabilities, mesenchymal stem cell-derived exosomes (MSC-Exos) have gained attention novel options for numerous disorders, including DIC. Their stability in diverse pathological states highlights potential promising candidates therapy. This review latest insights on pathogenesis anticoagulant properties MSC-Exos. We aimed elucidate mechanisms MSC-Exos influence pathogenesis. speculate that offer multifaceted approach treatment attenuating neutrophil extracellular trap formation, modulating M1/M2 macrophage polarization, altering Nrf2/NF-κB signalling pathway downregulate pro-inflammatory factors, correcting imbalances coagulation-fibrinolysis system through routes. suggests paradigm therapy, offering targets modalities management.

Language: Английский

Neutrophil extracellular traps in homeostasis and disease DOI Creative Commons

Han Wang,

Susan J. Kim,

Lei Yu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 20, 2024

Language: Английский

Citations

34
Hidradenitis suppurativa DOI Creative Commons
Robert Sabat, Afsáneh Alavi, Kerstin Wolk

et al.

The Lancet, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

7
Neutrophil extracellular traps in tumor metabolism and microenvironment DOI Creative Commons

Z. Liu,

Yuanyao Dou, Conghua Lu

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 23, 2025

Neutrophil extracellular traps (NETs) are intricate, web-like formations composed of DNA, histones, and antimicrobial proteins, released by neutrophils. These structures participate in a wide array physiological pathological activities, including immune rheumatic diseases damage to target organs. Recently, the connection between NETs cancer has garnered significant attention. Within tumor microenvironment metabolism, exhibit multifaceted roles, such as promoting proliferation migration cells, influencing redox balance, triggering angiogenesis, driving metabolic reprogramming. This review offers comprehensive analysis link emphasizing areas that remain underexplored. include interaction with mitochondria, their effect on states within tumors, involvement reprogramming, contribution angiogenesis tumors. Such insights lay theoretical foundation for deeper understanding role development. Moreover, also delves into potential therapeutic strategies suggests future research directions, offering new perspectives treatment other related diseases.

Language: Английский

Citations

3
Sivelestat sodium protects against renal ischemia/reperfusion injury by reduction of NETs formation DOI
Yanqi Liu, Yu Xin, Mengyao Yuan

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: 765, P. 110318 - 110318

Published: Jan. 23, 2025

Language: Английский

Citations

1
Novel Insights into Neuroinflammatory Mechanisms in Traumatic Brain Injury: Focus on Pattern Recognition Receptors as Therapeutic Targets DOI

Harapriya Baral,

Ravinder K. Kaundal

Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
Neutrophil Extracellular Traps in Breast Cancer: Roles in Metastasis and Beyond DOI Creative Commons

Xi Quan Xu,

Xinyu Wang,

Zhuomeng Zheng

et al.

Journal of Cancer, Journal Year: 2024, Volume and Issue: 15(11), P. 3272 - 3283

Published: Jan. 1, 2024

Despite advances in the treatment of breast cancer, disease continues to exhibit high global morbidity and mortality.The importance neutrophils cancer development has been increasingly recognized.Neutrophil extracellular traps (NETs) are web-like structures released into space by activated neutrophils, serving as a potential antimicrobial mechanism for capturing eliminating microorganisms.The roles played NETs have subject intense research last decade.In current evidence suggests that involved various stages development, particularly during metastasis.In this review, we try provide an updated overview metastasis.These include: 1) facilitating systemic dissemination cells; 2) promoting cancer-associated inflammation; 3) thrombosis; 4) pre-metastatic niche formation; 5) awakening dormant cells.The translational implications also discussed.Understanding relationship between metastasis is expected important insights developing new therapeutic strategies patients.

Language: Английский

Citations

4
Single-cell atlas of human gingiva unveils a NETs-related neutrophil subpopulation regulating periodontal immunity DOI Creative Commons
Wei Qiu,

Ruiming Guo,

Hongwen Yu

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Exaggerated neutrophil recruitment and activation are the major features of pathological alterations in periodontitis, which extracellular traps (NETs) considered to be responsible for inflammatory periodontal lesions. Despite critical role NETs development progression their specific functions mechanisms remain unclear.

Language: Английский

Citations

4
IL-33, a neutrophil extracellular trap-related gene involved in the progression of diabetic kidney disease DOI

Yufei Ye,

Anwen Huang,

Xinyan Huang

et al.

Inflammation Research, Journal Year: 2025, Volume and Issue: 74(1)

Published: Jan. 11, 2025

Language: Английский

Citations

0
The Diagnostic Value of Plasma NETs Levels and iCEB in Silent Myocardial Ischemia in Maintenance Hemodialysis Patients DOI Creative Commons
Haifei Liu,

Jun-Ling Han,

Wei‐Jie Ni

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 847 - 862

Published: Jan. 1, 2025

This study evaluated the diagnostic value of plasma Neutrophil extracellular traps (NETs) levels and index cardiac electrophysiological balance (iCEB) in identifying silent myocardial ischemia (SMI) maintenance hemodialysis (MHD) patients. cross-sectional observational involved patients receiving MHD treatment. Data were collected on coronary angiography performed our hospital from February 2023 to 2024. Patients diagnosed with via but without obvious symptoms grouped as SMI group, while those control group. Plasma NETs assessed using markers indicative components including double-stranded DNA (dsDNA), circulating free (cfDNA) myeloperoxidase, iCEB (QT/QRS) electrocardiographic findings obtained. Additionally, echocardiographic parameters, inflammatory markers, biomarkers analyzed. Receiver operating characteristic (ROC) analysis employed evaluate accuracy SMI. A total 114 included, 79 participants group 35 The exhibited significantly elevated associated (dsDNA(37.89±4.55 vs 31.64±5.32, P<0.001), cfDNA(11.27±2.03 8.91±1.84, MPO-DNA(23.69±4.01 17.52±3.41, P<0.001)), well higher compared group(56.45±7.67 45.89±6.23, P<0.001). Furthermore, electrocardiography findings, showed significant differences between two groups. ROC demonstrated potential accuracies iCEB, an area under curve (AUC) 0.908, sensitivity 0.987, specificity 0.829 for highlights combined patients, providing valuable insights into early detection risk stratification strategies this population.

Language: Английский

Citations

0
A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis DOI Open Access
Roxane Darbousset,

Leetah Senkpeil,

Julia Kuehn

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Systemic sclerosis (SSc) is characterized by progressive fibrosis of skin, lung, and other organs retains among the highest rates mortality autoimmune diseases. We identified activation circulating neutrophils from patients with diffuse SSc, together concordant transcriptomic evidence neutrophil in blood, lungs, mice experimental SSc skin lung induced hypochlorous acid or bleomycin. Neutrophil depletion abrogated while adoptive transfer healthy mice, identifying as both necessary sufficient for disease. In patients, platelet accompanied preceded activation, suggesting an upstream role. Platelet tissue fibrosis. platelets conferred upon capacity to induce SSc. This corresponded enhanced production extracellular traps (NETs); was NET-deficient PAD4 -/- a resistance bypassed PAD4-suficient neutrophils, confirming NETs key effector mechanism turn, mediated via collagen receptor GPVI, GPVI deficiency resulted attenuated fewer NETs, protection murine models Together, these findings define GPVI-platelet-neutrophil-NET axis identify new set therapeutic targets this often-refractory condition.

Language: Английский

Citations

0